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Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats.
Andrologia. 2018 Sep; 50(7):e13047.A

Abstract

This study was designed to determine the effects of daily oral administration (250 mg/kg) of the hydroalcoholic extract of Fumaria parviflora (FP) for 14 days on the sperm parameters, oxidative stress parameters, serum testosterone levels, expression of Bax and Bcl-2 genes, and apoptosis index of germ cells after testicular torsion-detorsion (ischaemia-reperfusion, IR) injury model in rats. Twenty-eight adult male Wistar rats were divided randomly into four groups of seven each: sham operation, torsion-detorsion (TD), TD plus the hydroalcoholic extract FP (TDFP) and only FP without TD application (FP). Testicular torsion was created by rotating the left testis 720° in a counterclockwise direction; then, after 4 hr, detorsion was performed. The Johnson's score, mean seminiferous tubule diameter (MSTD) and height (thickness) of seminiferous tubule epithelium (HST) were significantly increased in TDFP and FP groups as compared to TD group. The gene expression of Bcl-2, level of serum testosterone hormone and antioxidant parameters-GPx and SOD-were significantly higher in TDFP and FP groups than TD group. The index of apoptosis, the gene expression of Bax and the level of MDA were significantly higher in TD group than TDFP and FP groups. Therefore, F. parviflora could decrease oxidative stress induced by testicular torsion-detorsion.

Authors+Show Affiliations

Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29770471

Citation

Shokoohi, M, et al. "Protective Effects of the Hydroalcoholic Extract of Fumaria Parviflora On Testicular Injury Induced By Torsion/detorsion in Adult Rats." Andrologia, vol. 50, no. 7, 2018, pp. e13047.
Shokoohi M, Shoorei H, Soltani M, et al. Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats. Andrologia. 2018;50(7):e13047.
Shokoohi, M., Shoorei, H., Soltani, M., Abtahi-Eivari, S. H., Salimnejad, R., & Moghimian, M. (2018). Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats. Andrologia, 50(7), e13047. https://doi.org/10.1111/and.13047
Shokoohi M, et al. Protective Effects of the Hydroalcoholic Extract of Fumaria Parviflora On Testicular Injury Induced By Torsion/detorsion in Adult Rats. Andrologia. 2018;50(7):e13047. PubMed PMID: 29770471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats. AU - Shokoohi,M, AU - Shoorei,H, AU - Soltani,M, AU - Abtahi-Eivari,S-H, AU - Salimnejad,R, AU - Moghimian,M, Y1 - 2018/05/16/ PY - 2018/04/03/accepted PY - 2018/5/18/pubmed PY - 2019/6/7/medline PY - 2018/5/18/entrez KW - Fumaria parviflora KW - apoptosis KW - oxidative stress markers KW - testicular torsion-detorsion SP - e13047 EP - e13047 JF - Andrologia JO - Andrologia VL - 50 IS - 7 N2 - This study was designed to determine the effects of daily oral administration (250 mg/kg) of the hydroalcoholic extract of Fumaria parviflora (FP) for 14 days on the sperm parameters, oxidative stress parameters, serum testosterone levels, expression of Bax and Bcl-2 genes, and apoptosis index of germ cells after testicular torsion-detorsion (ischaemia-reperfusion, IR) injury model in rats. Twenty-eight adult male Wistar rats were divided randomly into four groups of seven each: sham operation, torsion-detorsion (TD), TD plus the hydroalcoholic extract FP (TDFP) and only FP without TD application (FP). Testicular torsion was created by rotating the left testis 720° in a counterclockwise direction; then, after 4 hr, detorsion was performed. The Johnson's score, mean seminiferous tubule diameter (MSTD) and height (thickness) of seminiferous tubule epithelium (HST) were significantly increased in TDFP and FP groups as compared to TD group. The gene expression of Bcl-2, level of serum testosterone hormone and antioxidant parameters-GPx and SOD-were significantly higher in TDFP and FP groups than TD group. The index of apoptosis, the gene expression of Bax and the level of MDA were significantly higher in TD group than TDFP and FP groups. Therefore, F. parviflora could decrease oxidative stress induced by testicular torsion-detorsion. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/29770471/Protective_effects_of_the_hydroalcoholic_extract_of_Fumaria_parviflora_on_testicular_injury_induced_by_torsion/detorsion_in_adult_rats_ DB - PRIME DP - Unbound Medicine ER -