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Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats.
J Cell Physiol. 2018 11; 233(11):8731-8739.JC

Abstract

Ochratoxin A (OTA), is a natural contaminant of the food chain worldwide involved in the development of different type of cancers in animals and humans. Several studies suggested that oxidative damage might contribute to increase the cytotoxicity and carcinogenicity capabilities of OTA. The aim of this study was to evaluate the possible protective effect of δ-tocotrienol (Delta), a natural form of vitamin E, against OTA-induced nephrotoxicity. Male Sprague-Dawley rats were treated with OTA and/or Delta by gavage for 14 days. Our results shown that OTA treatment induced the increase of reactive oxigen species production correlated to a strong reduction of Glomerular Filtration Rate (GFR) and absoluted fluid reabsorption (Jv) with conseguent significant increase in blood pressure. Consistent, we noted in the kidney of rats treated with OTA, an increase in malondialdheyde and dihydroethidium production and a reduction of the activity of the catalase, superoxide dismutase, and glutathione peroxidase. Conversly, in the rat group subjected to the concomitant treatment OTA plus Delta, we observed the restored effect, compared the OTA treatment group, on blood pressure, GFR, Jv, and all activities of renal antioxidant enzymes. Finally, as far as concern the tissue damage induced by OTA and measured evaluating fibronectin protein levels, we observed that in OTA plus Delta group this effect is not restored. Our findings releval that a mechanism underlying the renal toxicity induced by OTA is the oxidative stress and provide a new rationale to use a Delta in order to protect, at least in part, against OTA-induced nephrotoxicity.

Authors+Show Affiliations

Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy.Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy.Department of Cardiothoracic and Respiratory Science, University of Campania Luigi Vanvitelli, Naples, Italy.Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy.Oncology Research Center of Mercogliano (CROM), Istituto Nazionale Tumori-IRCCS, "Fondazione G. Pascale", Napoli, Italia.Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy. Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania.Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy.Department of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29775204

Citation

Damiano, Sara, et al. "Effects of Δ-tocotrienol On Ochratoxin A-induced Nephrotoxicity in Rats." Journal of Cellular Physiology, vol. 233, no. 11, 2018, pp. 8731-8739.
Damiano S, Navas L, Lombari P, et al. Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats. J Cell Physiol. 2018;233(11):8731-8739.
Damiano, S., Navas, L., Lombari, P., Montagnaro, S., Forte, I. M., Giordano, A., Florio, S., & Ciarcia, R. (2018). Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats. Journal of Cellular Physiology, 233(11), 8731-8739. https://doi.org/10.1002/jcp.26753
Damiano S, et al. Effects of Δ-tocotrienol On Ochratoxin A-induced Nephrotoxicity in Rats. J Cell Physiol. 2018;233(11):8731-8739. PubMed PMID: 29775204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats. AU - Damiano,Sara, AU - Navas,Luigi, AU - Lombari,Patrizia, AU - Montagnaro,Serena, AU - Forte,Iris M, AU - Giordano,Antonio, AU - Florio,Salvatore, AU - Ciarcia,Roberto, Y1 - 2018/05/18/ PY - 2018/04/16/received PY - 2018/04/18/accepted PY - 2018/5/19/pubmed PY - 2019/9/27/medline PY - 2018/5/19/entrez KW - nephrotoxicity KW - ochratoxin A KW - reactive oxigen species KW - δ-tocotrienol SP - 8731 EP - 8739 JF - Journal of cellular physiology JO - J Cell Physiol VL - 233 IS - 11 N2 - Ochratoxin A (OTA), is a natural contaminant of the food chain worldwide involved in the development of different type of cancers in animals and humans. Several studies suggested that oxidative damage might contribute to increase the cytotoxicity and carcinogenicity capabilities of OTA. The aim of this study was to evaluate the possible protective effect of δ-tocotrienol (Delta), a natural form of vitamin E, against OTA-induced nephrotoxicity. Male Sprague-Dawley rats were treated with OTA and/or Delta by gavage for 14 days. Our results shown that OTA treatment induced the increase of reactive oxigen species production correlated to a strong reduction of Glomerular Filtration Rate (GFR) and absoluted fluid reabsorption (Jv) with conseguent significant increase in blood pressure. Consistent, we noted in the kidney of rats treated with OTA, an increase in malondialdheyde and dihydroethidium production and a reduction of the activity of the catalase, superoxide dismutase, and glutathione peroxidase. Conversly, in the rat group subjected to the concomitant treatment OTA plus Delta, we observed the restored effect, compared the OTA treatment group, on blood pressure, GFR, Jv, and all activities of renal antioxidant enzymes. Finally, as far as concern the tissue damage induced by OTA and measured evaluating fibronectin protein levels, we observed that in OTA plus Delta group this effect is not restored. Our findings releval that a mechanism underlying the renal toxicity induced by OTA is the oxidative stress and provide a new rationale to use a Delta in order to protect, at least in part, against OTA-induced nephrotoxicity. SN - 1097-4652 UR - https://www.unboundmedicine.com/medline/citation/29775204/Effects_of_δ_tocotrienol_on_ochratoxin_A_induced_nephrotoxicity_in_rats_ L2 - https://doi.org/10.1002/jcp.26753 DB - PRIME DP - Unbound Medicine ER -