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Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations.
Cancer Epidemiol Biomarkers Prev 2018; 27(8):928-935CE

Abstract

Background:

Coffee intake has been associated with risk of various cancers, but the findings, mostly from studies in white populations, are inconsistent. We examined the association of coffee consumption with overall cancer incidence and specific cancer sites in a large prospective study of African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites.

Methods:

167,720 participants of the Multiethnic Cohort Study in Hawaii and Los Angeles were included. Baseline coffee intake was assessed by a validated food-frequency questionnaire. HRs and 95% confidence intervals (CIs) for sixteen cancers associated with coffee intake were calculated using Cox regressions.

Results:

During a mean follow-up of 15.3 years, 34,031 incident cancer cases were identified among study participants. Coffee intake was associated inversely with liver (≥4 cups/day vs. none: HR = 0.57; 95% CI, 0.38-0.87; Ptrend < 0.001), ovarian (HR = 0.33; 95% CI, 0.17-0.65; Ptrend = 0.007), and thyroid (HR = 0.44; 95% CI, 0.23-0.87; Ptrend = 0.007) cancers and melanoma (HR = 0.72; 95% CI, 0.52-0.99; Ptrend = 0.002). Coffee intake was also inversely associated with endometrial cancer among women with a body mass index >30 kg/m2 (HR = 0.31; 95% CI, 0.14-0.72; Ptrend = 0.04). The associations were similar across five ethnic groups (Pheterogeneity > 0.06) and were mainly observed among those who drank caffeinated coffee.

Conclusions:

On the basis of our prospective data in diverse populations, we found a decreased risk of liver, ovarian, thyroid, and endometrial cancers and melanoma associated with higher coffee intake.Impact: These results suggest that coffee drinking may protect against liver, ovarian, thyroid, and endometrial cancers, and melanoma. Cancer Epidemiol Biomarkers Prev; 27(8); 928-35. ©2018 AACR.

Authors+Show Affiliations

Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California.Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. vsetiawa@med.usc.edu. Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29777049

Citation

Park, Song-Yi, et al. "Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 27, no. 8, 2018, pp. 928-935.
Park SY, Freedman ND, Haiman CA, et al. Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations. Cancer Epidemiol Biomarkers Prev. 2018;27(8):928-935.
Park, S. Y., Freedman, N. D., Haiman, C. A., Le Marchand, L., Wilkens, L. R., & Setiawan, V. W. (2018). Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 27(8), pp. 928-935. doi:10.1158/1055-9965.EPI-18-0093.
Park SY, et al. Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations. Cancer Epidemiol Biomarkers Prev. 2018;27(8):928-935. PubMed PMID: 29777049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations. AU - Park,Song-Yi, AU - Freedman,Neal D, AU - Haiman,Christopher A, AU - Le Marchand,Loïc, AU - Wilkens,Lynne R, AU - Setiawan,Veronica Wendy, Y1 - 2018/05/18/ PY - 2018/02/05/received PY - 2018/04/05/revised PY - 2018/05/14/accepted PY - 2018/5/20/pubmed PY - 2019/9/14/medline PY - 2018/5/20/entrez SP - 928 EP - 935 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 27 IS - 8 N2 - Background: Coffee intake has been associated with risk of various cancers, but the findings, mostly from studies in white populations, are inconsistent. We examined the association of coffee consumption with overall cancer incidence and specific cancer sites in a large prospective study of African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites.Methods: 167,720 participants of the Multiethnic Cohort Study in Hawaii and Los Angeles were included. Baseline coffee intake was assessed by a validated food-frequency questionnaire. HRs and 95% confidence intervals (CIs) for sixteen cancers associated with coffee intake were calculated using Cox regressions.Results: During a mean follow-up of 15.3 years, 34,031 incident cancer cases were identified among study participants. Coffee intake was associated inversely with liver (≥4 cups/day vs. none: HR = 0.57; 95% CI, 0.38-0.87; Ptrend < 0.001), ovarian (HR = 0.33; 95% CI, 0.17-0.65; Ptrend = 0.007), and thyroid (HR = 0.44; 95% CI, 0.23-0.87; Ptrend = 0.007) cancers and melanoma (HR = 0.72; 95% CI, 0.52-0.99; Ptrend = 0.002). Coffee intake was also inversely associated with endometrial cancer among women with a body mass index >30 kg/m2 (HR = 0.31; 95% CI, 0.14-0.72; Ptrend = 0.04). The associations were similar across five ethnic groups (Pheterogeneity > 0.06) and were mainly observed among those who drank caffeinated coffee.Conclusions: On the basis of our prospective data in diverse populations, we found a decreased risk of liver, ovarian, thyroid, and endometrial cancers and melanoma associated with higher coffee intake.Impact: These results suggest that coffee drinking may protect against liver, ovarian, thyroid, and endometrial cancers, and melanoma. Cancer Epidemiol Biomarkers Prev; 27(8); 928-35. ©2018 AACR. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/29777049/Prospective_Study_of_Coffee_Consumption_and_Cancer_Incidence_in_Non_White_Populations_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=29777049 DB - PRIME DP - Unbound Medicine ER -