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Formulation techniques for high dose dry powders.
Int J Pharm. 2018 Aug 25; 547(1-2):489-498.IJ

Abstract

Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for the pulmonary deposition of potent bronchodilators, anticholinergics, and corticosteroids, there is growing interest in the utilization of this delivery system for the administration of high drug doses to the lungs, as made evident by recent regulatory approvals for anti-microbial, anti-viral and osmotic agents. However, the formulation of high dose DPIs carries several challenges from both a physiological and physicochemical standpoint. This review describes the various formulation techniques utilized to overcome the barriers associated with the pulmonary delivery of high dose powders.

Authors+Show Affiliations

University of Texas at Austin, College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, 2409 West University Avenue, Austin, TX 78712, United States.University of Texas at Austin, College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery, 2409 West University Avenue, Austin, TX 78712, United States; LaMontagne Center for Infectious Disease, The University of Texas at Austin, United States. Electronic address: hugh.smyth@austin.utexas.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29778822

Citation

Brunaugh, Ashlee D., and Hugh D C. Smyth. "Formulation Techniques for High Dose Dry Powders." International Journal of Pharmaceutics, vol. 547, no. 1-2, 2018, pp. 489-498.
Brunaugh AD, Smyth HDC. Formulation techniques for high dose dry powders. Int J Pharm. 2018;547(1-2):489-498.
Brunaugh, A. D., & Smyth, H. D. C. (2018). Formulation techniques for high dose dry powders. International Journal of Pharmaceutics, 547(1-2), 489-498. https://doi.org/10.1016/j.ijpharm.2018.05.036
Brunaugh AD, Smyth HDC. Formulation Techniques for High Dose Dry Powders. Int J Pharm. 2018 Aug 25;547(1-2):489-498. PubMed PMID: 29778822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation techniques for high dose dry powders. AU - Brunaugh,Ashlee D, AU - Smyth,Hugh D C, Y1 - 2018/05/17/ PY - 2018/03/15/received PY - 2018/05/14/revised PY - 2018/05/15/accepted PY - 2018/5/21/pubmed PY - 2018/10/26/medline PY - 2018/5/21/entrez KW - Carrier-free KW - Dry powder formulation KW - Dry powder inhalers KW - High dose delivery KW - Inhalation KW - Particle engineering SP - 489 EP - 498 JF - International journal of pharmaceutics JO - Int J Pharm VL - 547 IS - 1-2 N2 - Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for the pulmonary deposition of potent bronchodilators, anticholinergics, and corticosteroids, there is growing interest in the utilization of this delivery system for the administration of high drug doses to the lungs, as made evident by recent regulatory approvals for anti-microbial, anti-viral and osmotic agents. However, the formulation of high dose DPIs carries several challenges from both a physiological and physicochemical standpoint. This review describes the various formulation techniques utilized to overcome the barriers associated with the pulmonary delivery of high dose powders. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/29778822/Formulation_techniques_for_high_dose_dry_powders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(18)30344-2 DB - PRIME DP - Unbound Medicine ER -