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The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis.
Nutr Metab Cardiovasc Dis. 2018 07; 28(7):657-674.NM

Abstract

BACKGROUND & AIMS

Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations.

METHODS AND RESULTS

PubMed/Medline, Web of Knowledge, and Scopus electronic databases were searched until May 31, 2017 to find relevant English-language papers. We included studies that examined the association of NC with risk of MetS, or at minimum, one of its components as outcomes. Of 2628 publications identified, 19 papers met selection criteria. We found no association between NC and MetS (odd ratio (OR): 0.73; 95% CI: 0.003, 1.47). However, there was a positive association between NC and waist circumference (WC) (r = 0.85; 95%: 0.75, 0.95; I[2]: 98.2%; p = 0.0001), BMI: (r:0.88; 95% CI: 0.74, 0.91, I[2]:97.3%), triglycerides (TG) (OR: 1.87; 95% CI: 1.60, 2.19; I[2]:58.4%; p = 0.03), TC (r:0.14; 95%CI: 0.05, 0.23, I[2]:94.1%), LDL-C (r: 0.18; 95%CI: 0.07, 0.29, I[2]:94.3%), hypertension (OR: 1.94; 95% CI:1.43, 2.64, I[2]:87.3%), systolic (r: 0.21, 95%CI: 0.19, 0.23; I[2]:67.1%) and diastolic blood pressures (r: 0.20, 95%CI: 0.16, 0.23; I[2]:79.7%), low HDL-C (r:-0.21; 95% CI: -0.26, -0.15, I[2] = 92.5%), as well as fasting blood sugar (FBS) concentrations (r: 0.20, 95%CI: 0.16, 0.24; I[2]:88.1%).

CONCLUSION

Subjects with higher NC were at approximately two-fold higher risk for hypertriglyceridemia compared to those with lower NC. We found positive associations between NC, WC, BMI, hypertension, FBS, TC, LDL-C, SBP, DBP, and low HDL-C concentrations. However, heterogeneity was considerably high. Therefore, the findings should be taken with caution. Future studies using longitudinal designs are needed to further understand the association between NC and features of MetS.

Authors+Show Affiliations

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: larijanib@tums.ac.ir.Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: azadbakhtleila@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

29779782

Citation

Namazi, N, et al. "The Association of Neck Circumference With Risk of Metabolic Syndrome and Its Components in Adults: a Systematic Review and Meta-analysis." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 28, no. 7, 2018, pp. 657-674.
Namazi N, Larijani B, Surkan PJ, et al. The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2018;28(7):657-674.
Namazi, N., Larijani, B., Surkan, P. J., & Azadbakht, L. (2018). The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 28(7), 657-674. https://doi.org/10.1016/j.numecd.2018.03.006
Namazi N, et al. The Association of Neck Circumference With Risk of Metabolic Syndrome and Its Components in Adults: a Systematic Review and Meta-analysis. Nutr Metab Cardiovasc Dis. 2018;28(7):657-674. PubMed PMID: 29779782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis. AU - Namazi,N, AU - Larijani,B, AU - Surkan,P J, AU - Azadbakht,L, Y1 - 2018/03/21/ PY - 2017/10/21/received PY - 2018/03/11/revised PY - 2018/03/12/accepted PY - 2018/5/22/pubmed PY - 2019/3/15/medline PY - 2018/5/22/entrez KW - Adults KW - Cardio-metabolic risks KW - MetS KW - Meta-analysis KW - Neck SP - 657 EP - 674 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 28 IS - 7 N2 - BACKGROUND & AIMS: Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations. METHODS AND RESULTS: PubMed/Medline, Web of Knowledge, and Scopus electronic databases were searched until May 31, 2017 to find relevant English-language papers. We included studies that examined the association of NC with risk of MetS, or at minimum, one of its components as outcomes. Of 2628 publications identified, 19 papers met selection criteria. We found no association between NC and MetS (odd ratio (OR): 0.73; 95% CI: 0.003, 1.47). However, there was a positive association between NC and waist circumference (WC) (r = 0.85; 95%: 0.75, 0.95; I[2]: 98.2%; p = 0.0001), BMI: (r:0.88; 95% CI: 0.74, 0.91, I[2]:97.3%), triglycerides (TG) (OR: 1.87; 95% CI: 1.60, 2.19; I[2]:58.4%; p = 0.03), TC (r:0.14; 95%CI: 0.05, 0.23, I[2]:94.1%), LDL-C (r: 0.18; 95%CI: 0.07, 0.29, I[2]:94.3%), hypertension (OR: 1.94; 95% CI:1.43, 2.64, I[2]:87.3%), systolic (r: 0.21, 95%CI: 0.19, 0.23; I[2]:67.1%) and diastolic blood pressures (r: 0.20, 95%CI: 0.16, 0.23; I[2]:79.7%), low HDL-C (r:-0.21; 95% CI: -0.26, -0.15, I[2] = 92.5%), as well as fasting blood sugar (FBS) concentrations (r: 0.20, 95%CI: 0.16, 0.24; I[2]:88.1%). CONCLUSION: Subjects with higher NC were at approximately two-fold higher risk for hypertriglyceridemia compared to those with lower NC. We found positive associations between NC, WC, BMI, hypertension, FBS, TC, LDL-C, SBP, DBP, and low HDL-C concentrations. However, heterogeneity was considerably high. Therefore, the findings should be taken with caution. Future studies using longitudinal designs are needed to further understand the association between NC and features of MetS. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/29779782/The_association_of_neck_circumference_with_risk_of_metabolic_syndrome_and_its_components_in_adults:_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -