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Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.
Environ Pollut. 2018 Sep; 240:817-830.EP

Abstract

Recent studies suggest an association between particulate matter (PM) air pollution and gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited in oropharynx via mucociliary clearance and upon swallowing of saliva and mucus. Within the GI tract, PM may alter the GI epithelium and gut microbiome. Our goal was to determine the effect of PM on gut microbiota in a murine model of PM exposure via inhalation. C57BL/6 mice were exposed via inhalation to either concentrated ambient particles or filtered air for 8-h per day, 5-days a week, for a total of 3-weeks. At exposure's end, GI tract tissues and feces were harvested, and gut microbiota was analyzed. Alpha-diversity was modestly altered with increased richness in PM-exposed mice compared to air-exposed mice in some parts of the GI tract. Most importantly, PM-induced alterations in the microbiota were very apparent in beta-diversity comparisons throughout the GI tract and appeared to increase from the proximal to distal parts. Changes in some genera suggest that distinct bacteria may have the capacity to bloom with PM exposure. Exposure to PM alters the microbiota throughout the GI tract which maybe a potential mechanism that explains PM induced inflammation in the GI tract.

Authors+Show Affiliations

Division of Digestive Diseases, Hepatology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address: Ece_Mutlu@rush.edu.Division of Digestive Diseases, Hepatology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address: yagmurcomba@gmail.com.Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: jared.cho@gmail.com.Division of Digestive Diseases, Hepatology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address: Phillip_A_Engen@rush.edu.Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address: cemalyazici@yahoo.com.Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: saulaxo@gmail.com.Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: rhamanaka@medicine.bsd.uchicago.edu.Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: recep@uchicago.edu.Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: ameliton@medicine.bsd.uchicago.edu.United States Environmental Protection Agency, Chapel Hill, NC, 27599, USA. Electronic address: Ghio.Andy@epa.gov.Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: s-buding@northwestern.edu.Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: gmutlu@medicine.bsd.uchicago.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29783199

Citation

Mutlu, Ece A., et al. "Inhalational Exposure to Particulate Matter Air Pollution Alters the Composition of the Gut Microbiome." Environmental Pollution (Barking, Essex : 1987), vol. 240, 2018, pp. 817-830.
Mutlu EA, Comba IY, Cho T, et al. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. Environ Pollut. 2018;240:817-830.
Mutlu, E. A., Comba, I. Y., Cho, T., Engen, P. A., Yazıcı, C., Soberanes, S., Hamanaka, R. B., Niğdelioğlu, R., Meliton, A. Y., Ghio, A. J., Budinger, G. R. S., & Mutlu, G. M. (2018). Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. Environmental Pollution (Barking, Essex : 1987), 240, 817-830. https://doi.org/10.1016/j.envpol.2018.04.130
Mutlu EA, et al. Inhalational Exposure to Particulate Matter Air Pollution Alters the Composition of the Gut Microbiome. Environ Pollut. 2018;240:817-830. PubMed PMID: 29783199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. AU - Mutlu,Ece A, AU - Comba,Işın Y, AU - Cho,Takugo, AU - Engen,Phillip A, AU - Yazıcı,Cemal, AU - Soberanes,Saul, AU - Hamanaka,Robert B, AU - Niğdelioğlu,Recep, AU - Meliton,Angelo Y, AU - Ghio,Andrew J, AU - Budinger,G R Scott, AU - Mutlu,Gökhan M, Y1 - 2018/05/18/ PY - 2018/01/05/received PY - 2018/04/11/revised PY - 2018/04/27/accepted PY - 2018/5/22/pubmed PY - 2018/9/14/medline PY - 2018/5/22/entrez KW - Air pollution KW - Feces KW - Gastrointestinal KW - Intestine KW - Microbiota SP - 817 EP - 830 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 240 N2 - Recent studies suggest an association between particulate matter (PM) air pollution and gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited in oropharynx via mucociliary clearance and upon swallowing of saliva and mucus. Within the GI tract, PM may alter the GI epithelium and gut microbiome. Our goal was to determine the effect of PM on gut microbiota in a murine model of PM exposure via inhalation. C57BL/6 mice were exposed via inhalation to either concentrated ambient particles or filtered air for 8-h per day, 5-days a week, for a total of 3-weeks. At exposure's end, GI tract tissues and feces were harvested, and gut microbiota was analyzed. Alpha-diversity was modestly altered with increased richness in PM-exposed mice compared to air-exposed mice in some parts of the GI tract. Most importantly, PM-induced alterations in the microbiota were very apparent in beta-diversity comparisons throughout the GI tract and appeared to increase from the proximal to distal parts. Changes in some genera suggest that distinct bacteria may have the capacity to bloom with PM exposure. Exposure to PM alters the microbiota throughout the GI tract which maybe a potential mechanism that explains PM induced inflammation in the GI tract. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/29783199/Inhalational_exposure_to_particulate_matter_air_pollution_alters_the_composition_of_the_gut_microbiome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(17)35155-2 DB - PRIME DP - Unbound Medicine ER -