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Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii.
Chem Biodivers. 2018 Jul; 15(7):e1800147.CB

Abstract

Aconitum carmichaelii Debeaux is a widely used traditional Chinese medicine and an important source of clinical drugs, of which the parent and lateral roots are known as 'Chuanwu' and 'Fuzi', respectively. Four new C19 -diterpenoid alkaloids, carmichasines A - D (1 - 4), were isolated from the roots of Aconitum carmichaelii, together with twelve known compounds (5 - 16). Their structures were elucidated via spectroscopic analyses, including HR-ESI-MS, IR, and NMR. Carmichasine A (1) is the first natural C19 -diterpenoid alkaloid possessing a cyano group. Most of the diterpenoid alkaloids isolated were C19 -category, which might provide further clues for understanding the chemotaxonomic significance of this plant. The cytotoxicity of the new compounds was also investigated against several human cancer cell lines, including MCF-7, HCT116, A549, and 786-0, and none of them showed considerable cytotoxic activity.

Authors+Show Affiliations

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China.School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China.School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China.School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29785743

Citation

Li, Yu, et al. "Four New Diterpenoid Alkaloids From the Roots of Aconitum Carmichaelii." Chemistry & Biodiversity, vol. 15, no. 7, 2018, pp. e1800147.
Li Y, Gao F, Zhang JF, et al. Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii. Chem Biodivers. 2018;15(7):e1800147.
Li, Y., Gao, F., Zhang, J. F., & Zhou, X. L. (2018). Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii. Chemistry & Biodiversity, 15(7), e1800147. https://doi.org/10.1002/cbdv.201800147
Li Y, et al. Four New Diterpenoid Alkaloids From the Roots of Aconitum Carmichaelii. Chem Biodivers. 2018;15(7):e1800147. PubMed PMID: 29785743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii. AU - Li,Yu, AU - Gao,Feng, AU - Zhang,Ji-Fa, AU - Zhou,Xian-Li, Y1 - 2018/06/22/ PY - 2018/04/10/received PY - 2018/05/16/accepted PY - 2018/5/23/pubmed PY - 2018/7/28/medline PY - 2018/5/23/entrez KW - Aconitum carmichaelii KW - C19-diterpenoid alkaloids KW - Ranunculaceae KW - carmichasines A - D KW - cytotoxic activities SP - e1800147 EP - e1800147 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 15 IS - 7 N2 - Aconitum carmichaelii Debeaux is a widely used traditional Chinese medicine and an important source of clinical drugs, of which the parent and lateral roots are known as 'Chuanwu' and 'Fuzi', respectively. Four new C19 -diterpenoid alkaloids, carmichasines A - D (1 - 4), were isolated from the roots of Aconitum carmichaelii, together with twelve known compounds (5 - 16). Their structures were elucidated via spectroscopic analyses, including HR-ESI-MS, IR, and NMR. Carmichasine A (1) is the first natural C19 -diterpenoid alkaloid possessing a cyano group. Most of the diterpenoid alkaloids isolated were C19 -category, which might provide further clues for understanding the chemotaxonomic significance of this plant. The cytotoxicity of the new compounds was also investigated against several human cancer cell lines, including MCF-7, HCT116, A549, and 786-0, and none of them showed considerable cytotoxic activity. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/29785743/Four_New_Diterpenoid_Alkaloids_from_the_Roots_of_Aconitum_carmichaelii_ L2 - https://doi.org/10.1002/cbdv.201800147 DB - PRIME DP - Unbound Medicine ER -