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[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]
Eksp Klin Farmakol. 2016; 79(9):3-11.EK

Abstract

Pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of heptapeptide selank (300 μg/kg/day for 5 days), known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze behavior of inbred BALB/c and C57BL/6 mice and measuring the binding of markers to NMDA and GABA receptors of brain. The anxiolytic and nootropic efficiency of selank administered via both routes was observed only in BALB/c mice, which were characterized by initially reduced exploratory activity and higher levels of anxiety as compared to C57BL/6 mice. In BALB/c mice, i.p. selank increased the number of [G-(3)H]SR 95531 binding sites with GABA-receptors in the frontal cortex by 38%, without change in binding to NMDA receptors in the hippocampus. On the contrary, i.n. selank led to an increase in the density of [G-(3)H]MK-801 binding sites by 23% with no effect on GABA receptors. It is suggested that the differences in pharmacological spectra observed for the two routes of selank administration are determined by specific features of drug pharmacokinetics and biotransformation as well as by the dynamics of formation of the anxiolytic and nootropic effects of selank.

Authors

Vasil'eva EV
No affiliation info available
Kondrakhin EA
No affiliation info available
Salimov RM
No affiliation info available
Kovalev GI
No affiliation info available

MeSH

Administration, IntranasalAnimalsAnti-Anxiety AgentsBrainInjections, IntraperitonealMaleMiceMice, Inbred BALB CNootropic AgentsOligopeptidesReceptors, GABAReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

29787664

Citation

Vasil'eva, E V., et al. "[COMPARISON of PHARMACOLOGICAL EFFECTS of HEPTAPEPTIDE SELANK AFTER INTRANASAL and INTRAPERITONEAL ADMINISTRATION to BALB/c and C57BL/6 MICE.]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 79, no. 9, 2016, pp. 3-11.
Vasil'eva EV, Kondrakhin EA, Salimov RM, et al. [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]. Eksp Klin Farmakol. 2016;79(9):3-11.
Vasil'eva, E. V., Kondrakhin, E. A., Salimov, R. M., & Kovalev, G. I. (2016). [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]. Eksperimental'naia I Klinicheskaia Farmakologiia, 79(9), 3-11.
Vasil'eva EV, et al. [COMPARISON of PHARMACOLOGICAL EFFECTS of HEPTAPEPTIDE SELANK AFTER INTRANASAL and INTRAPERITONEAL ADMINISTRATION to BALB/c and C57BL/6 MICE.]. Eksp Klin Farmakol. 2016;79(9):3-11. PubMed PMID: 29787664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.] AU - Vasil'eva,E V, AU - Kondrakhin,E A, AU - Salimov,R M, AU - Kovalev,G I, PY - 2018/5/23/entrez PY - 2016/1/1/pubmed PY - 2016/1/1/medline SP - 3 EP - 11 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 79 IS - 9 N2 - Pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of heptapeptide selank (300 μg/kg/day for 5 days), known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze behavior of inbred BALB/c and C57BL/6 mice and measuring the binding of markers to NMDA and GABA receptors of brain. The anxiolytic and nootropic efficiency of selank administered via both routes was observed only in BALB/c mice, which were characterized by initially reduced exploratory activity and higher levels of anxiety as compared to C57BL/6 mice. In BALB/c mice, i.p. selank increased the number of [G-(3)H]SR 95531 binding sites with GABA-receptors in the frontal cortex by 38%, without change in binding to NMDA receptors in the hippocampus. On the contrary, i.n. selank led to an increase in the density of [G-(3)H]MK-801 binding sites by 23% with no effect on GABA receptors. It is suggested that the differences in pharmacological spectra observed for the two routes of selank administration are determined by specific features of drug pharmacokinetics and biotransformation as well as by the dynamics of formation of the anxiolytic and nootropic effects of selank. SN - 0869-2092 UR - https://www.unboundmedicine.com/medline/citation/29787664/[COMPARISON_OF_PHARMACOLOGICAL_EFFECTS_OF_HEPTAPEPTIDE_SELANK_AFTER_INTRANASAL_AND_INTRAPERITONEAL_ADMINISTRATION_TO_BALB/c_AND_C57BL/6_MICE_] DB - PRIME DP - Unbound Medicine ER -