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Magnesium as a Calcification Inhibitor.
Adv Chronic Kidney Dis. 2018 05; 25(3):281-290.AC

Abstract

Vascular calcification (VC) is associated with elevated cardiovascular mortality rates in patients with CKD. Recent clinical studies of patients with advanced CKD have observed an association between low serum magnesium (Mg) levels on one hand and elevated VC and cardiovascular mortality on the other. These findings have stimulated interest in understanding Mg's impact on CKD in general and the associated VC in particular. In vitro and preclinical in vivo data indicate that Mg has the potential to protect vascular smooth muscle cells against calcification via several different molecular mechanisms. Accordingly, data from pilot interventional studies in the clinic suggest that oral Mg supplementation reduces VC in patients with CKD. The present review provides an overview of our current understanding of the impact of Mg on the development of VC in patients with CKD.

Authors+Show Affiliations

INSERM U1088, CURS, Amiens, France; Division of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France; INSERM U1018, Team 5, CESP, UVSQ, Villejuif, France.INSERM U1088, CURS, Amiens, France; Division of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France; INSERM U1018, Team 5, CESP, UVSQ, Villejuif, France. Electronic address: ziad.massy@aphp.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29793668

Citation

Hénaut, Lucie, and Ziad A. Massy. "Magnesium as a Calcification Inhibitor." Advances in Chronic Kidney Disease, vol. 25, no. 3, 2018, pp. 281-290.
Hénaut L, Massy ZA. Magnesium as a Calcification Inhibitor. Adv Chronic Kidney Dis. 2018;25(3):281-290.
Hénaut, L., & Massy, Z. A. (2018). Magnesium as a Calcification Inhibitor. Advances in Chronic Kidney Disease, 25(3), 281-290. https://doi.org/10.1053/j.ackd.2017.12.001
Hénaut L, Massy ZA. Magnesium as a Calcification Inhibitor. Adv Chronic Kidney Dis. 2018;25(3):281-290. PubMed PMID: 29793668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium as a Calcification Inhibitor. AU - Hénaut,Lucie, AU - Massy,Ziad A, PY - 2017/07/07/received PY - 2017/12/05/revised PY - 2017/12/05/accepted PY - 2018/5/26/entrez PY - 2018/5/26/pubmed PY - 2019/10/8/medline KW - Chronic kidney disease KW - Magnesium KW - Vascular calcification SP - 281 EP - 290 JF - Advances in chronic kidney disease JO - Adv Chronic Kidney Dis VL - 25 IS - 3 N2 - Vascular calcification (VC) is associated with elevated cardiovascular mortality rates in patients with CKD. Recent clinical studies of patients with advanced CKD have observed an association between low serum magnesium (Mg) levels on one hand and elevated VC and cardiovascular mortality on the other. These findings have stimulated interest in understanding Mg's impact on CKD in general and the associated VC in particular. In vitro and preclinical in vivo data indicate that Mg has the potential to protect vascular smooth muscle cells against calcification via several different molecular mechanisms. Accordingly, data from pilot interventional studies in the clinic suggest that oral Mg supplementation reduces VC in patients with CKD. The present review provides an overview of our current understanding of the impact of Mg on the development of VC in patients with CKD. SN - 1548-5609 UR - https://www.unboundmedicine.com/medline/citation/29793668/Magnesium_as_a_Calcification_Inhibitor_ DB - PRIME DP - Unbound Medicine ER -