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Improvement in LDL is associated with decrease in non-calcified plaque volume on coronary CTA as measured by automated quantitative software.
J Cardiovasc Comput Tomogr. 2018 Sep - Oct; 12(5):385-390.JC

Abstract

BACKGROUND

Computed tomography coronary angiography (CTA) can be used for assessment of plaque characteristics; however, quantitative assessment of changes in plaque composition in response to LDL lowering has not been performed with CTA. We sought to assess the association between LDL reduction and changes in plaque composition with quantitative CTA.

METHODS

Quantification of total, calcified, non-calcified and low-density non-calcified plaque volumes (TPV, CPV, NCPV and LD-NCPV) was performed using semi-automated software in 234 vessels from 116 consecutive patients (89 men, 60 ± 10 years) with baseline LDL>70 mg/dl. Significant reduction in LDL was defined as a decrease by >10% of baseline LDL. Changes (Δ) in plaque volumes between the second and baseline study were compared between patients with LDL reduction (n = 63) and those with no decrease in LDL (n = 53).

RESULTS

Median LDL at baseline was 98 mg/dl [interquartile range (IQR) 83-119 mg/dl] and median ΔLDL was -14 mg/dl (IQR -38 to 3 mg/dl). Mean interval between sequential CTA was 3.5 ± 1.6 years. TPV, NCPV, and LD-NCPV decreased in patients with a reduction in LDL compared to baseline; whereas, patients without reduction in LDL experienced an increase in TPV, NCPV and LD-NCPV. After adjusting for age, statin use, diabetes, baseline LDL and baseline TPV, reduction in LDL was associated with a decrease in TPV (P = 0.005), NCPV (P = 0.002) and LD-NCPV (P = 0.011) compared to patients without a reduction in LDL.

CONCLUSION

Reduction in LDL was associated with beneficial changes in the amount and composition of noncalcified plaque as measured using semi-automated quantitative software by CTA.

Authors+Show Affiliations

Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA; Department of Medicine and Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA; Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA. Electronic address: balaji.tamarappoo@cshs.org.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA; Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA; Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, USA; Department of Medicine and Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA; Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29793847

Citation

Tamarappoo, Balaji, et al. "Improvement in LDL Is Associated With Decrease in Non-calcified Plaque Volume On Coronary CTA as Measured By Automated Quantitative Software." Journal of Cardiovascular Computed Tomography, vol. 12, no. 5, 2018, pp. 385-390.
Tamarappoo B, Otaki Y, Doris M, et al. Improvement in LDL is associated with decrease in non-calcified plaque volume on coronary CTA as measured by automated quantitative software. J Cardiovasc Comput Tomogr. 2018;12(5):385-390.
Tamarappoo, B., Otaki, Y., Doris, M., Arnson, Y., Gransar, H., Hayes, S., Friedman, J., Thomson, L., Wang, F., Rozanski, A., Slomka, P., Dey, D., & Berman, D. (2018). Improvement in LDL is associated with decrease in non-calcified plaque volume on coronary CTA as measured by automated quantitative software. Journal of Cardiovascular Computed Tomography, 12(5), 385-390. https://doi.org/10.1016/j.jcct.2018.05.004
Tamarappoo B, et al. Improvement in LDL Is Associated With Decrease in Non-calcified Plaque Volume On Coronary CTA as Measured By Automated Quantitative Software. J Cardiovasc Comput Tomogr. 2018 Sep - Oct;12(5):385-390. PubMed PMID: 29793847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement in LDL is associated with decrease in non-calcified plaque volume on coronary CTA as measured by automated quantitative software. AU - Tamarappoo,Balaji, AU - Otaki,Yuka, AU - Doris,Mhairi, AU - Arnson,Yoav, AU - Gransar,Heidi, AU - Hayes,Sean, AU - Friedman,John, AU - Thomson,Louise, AU - Wang,Frances, AU - Rozanski,Alan, AU - Slomka,Piotr, AU - Dey,Damini, AU - Berman,Daniel, Y1 - 2018/05/07/ PY - 2018/01/24/received PY - 2018/04/12/revised PY - 2018/05/03/accepted PY - 2018/5/26/pubmed PY - 2018/11/27/medline PY - 2018/5/26/entrez KW - Atherosclerosis KW - Computerized tomography KW - Imaging KW - Lipids KW - cholesterol SP - 385 EP - 390 JF - Journal of cardiovascular computed tomography JO - J Cardiovasc Comput Tomogr VL - 12 IS - 5 N2 - BACKGROUND: Computed tomography coronary angiography (CTA) can be used for assessment of plaque characteristics; however, quantitative assessment of changes in plaque composition in response to LDL lowering has not been performed with CTA. We sought to assess the association between LDL reduction and changes in plaque composition with quantitative CTA. METHODS: Quantification of total, calcified, non-calcified and low-density non-calcified plaque volumes (TPV, CPV, NCPV and LD-NCPV) was performed using semi-automated software in 234 vessels from 116 consecutive patients (89 men, 60 ± 10 years) with baseline LDL>70 mg/dl. Significant reduction in LDL was defined as a decrease by >10% of baseline LDL. Changes (Δ) in plaque volumes between the second and baseline study were compared between patients with LDL reduction (n = 63) and those with no decrease in LDL (n = 53). RESULTS: Median LDL at baseline was 98 mg/dl [interquartile range (IQR) 83-119 mg/dl] and median ΔLDL was -14 mg/dl (IQR -38 to 3 mg/dl). Mean interval between sequential CTA was 3.5 ± 1.6 years. TPV, NCPV, and LD-NCPV decreased in patients with a reduction in LDL compared to baseline; whereas, patients without reduction in LDL experienced an increase in TPV, NCPV and LD-NCPV. After adjusting for age, statin use, diabetes, baseline LDL and baseline TPV, reduction in LDL was associated with a decrease in TPV (P = 0.005), NCPV (P = 0.002) and LD-NCPV (P = 0.011) compared to patients without a reduction in LDL. CONCLUSION: Reduction in LDL was associated with beneficial changes in the amount and composition of noncalcified plaque as measured using semi-automated quantitative software by CTA. SN - 1876-861X UR - https://www.unboundmedicine.com/medline/citation/29793847/Improvement_in_LDL_is_associated_with_decrease_in_non_calcified_plaque_volume_on_coronary_CTA_as_measured_by_automated_quantitative_software_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-5925(18)30094-7 DB - PRIME DP - Unbound Medicine ER -