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The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O2-O3) injection in patients with knee osteoarthritis: a randomized controlled trial.
Clin Rheumatol 2018; 37(9):2517-2527CR

Abstract

Osteoarthritis (OA) is a chronic multifactorial disease characterized by progressive joint degeneration. The purpose of this study was to compare the effects of ultrasound-guided corticosteroid injection with oxygen-ozone injection in patients with knee OA. This double-blind randomized clinical trial was performed on 62 patients with knee OA. The patients were randomly divided into two groups. In the first group 40 mg triamcinolone (1 cc) and in the second group 10 cc (15 μg/ml) oxygen-ozone (O2-O3) were injected into the knee joint under ultrasound guidance. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis (WOMAC), knee flexion range of motion (ROM), effusion in ultrasound images of the suprapatellar recess, and visual analog scale (VAS), which were evaluated before injection, 1 week, 1 month, and 3 months after the treatment. Sixty-two patients (10 men and 52 women) were enrolled with mean age of 57.9 years. VAS improved in both groups (steroid P value = 0.001, oxygen-ozone P value > 0.001). The improvements seen in VAS and WOMAC scores 3 months after treatment were in favor of the oxygen-ozone group when compared to the steroid group (P = 0.041 vs P = 0.19). There was no significant difference between the two groups in ROM and joint effusion seen under ultrasound (ROM p = 0.880, effusion p = 0.362). However, in the oxygen-ozone-receiving group, joint effusion was decreased significantly (p < 0.001). Both steroid and oxygen-ozone injections are effective in patients with knee osteoarthritis. Our study showed that the effects of oxygen-ozone injection last longer than those of steroid injection to the knee joint.

Authors+Show Affiliations

Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.Physical Medicine and Rehabilitation specialist with subspecialty in Interventional Pain Management, Clinical director, Mission Pain and Spine, Mission Viejo, CA, USA.Physical Medicine and Rehabilitation Research Center, Department of Physical Medicine and Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran. binasadat@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29796866

Citation

Babaei-Ghazani, Arash, et al. "The Effects of Ultrasound-guided Corticosteroid Injection Compared to Oxygen-ozone (O2-O3) Injection in Patients With Knee Osteoarthritis: a Randomized Controlled Trial." Clinical Rheumatology, vol. 37, no. 9, 2018, pp. 2517-2527.
Babaei-Ghazani A, Najarzadeh S, Mansoori K, et al. The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O2-O3) injection in patients with knee osteoarthritis: a randomized controlled trial. Clin Rheumatol. 2018;37(9):2517-2527.
Babaei-Ghazani, A., Najarzadeh, S., Mansoori, K., Forogh, B., Madani, S. P., Ebadi, S., ... Eftekharsadat, B. (2018). The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O2-O3) injection in patients with knee osteoarthritis: a randomized controlled trial. Clinical Rheumatology, 37(9), pp. 2517-2527. doi:10.1007/s10067-018-4147-6.
Babaei-Ghazani A, et al. The Effects of Ultrasound-guided Corticosteroid Injection Compared to Oxygen-ozone (O2-O3) Injection in Patients With Knee Osteoarthritis: a Randomized Controlled Trial. Clin Rheumatol. 2018;37(9):2517-2527. PubMed PMID: 29796866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (O2-O3) injection in patients with knee osteoarthritis: a randomized controlled trial. AU - Babaei-Ghazani,Arash, AU - Najarzadeh,Saeedeh, AU - Mansoori,Korosh, AU - Forogh,Bijan, AU - Madani,Seyed Pezhman, AU - Ebadi,Safoora, AU - Fadavi,Hamid Reza, AU - Eftekharsadat,Bina, Y1 - 2018/05/24/ PY - 2018/02/15/received PY - 2018/05/10/accepted PY - 2018/04/11/revised PY - 2018/5/26/pubmed PY - 2019/1/12/medline PY - 2018/5/26/entrez KW - Corticosteroid KW - Knee KW - Osteoarthritis KW - Oxygen–ozone KW - Sonography SP - 2517 EP - 2527 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 37 IS - 9 N2 - Osteoarthritis (OA) is a chronic multifactorial disease characterized by progressive joint degeneration. The purpose of this study was to compare the effects of ultrasound-guided corticosteroid injection with oxygen-ozone injection in patients with knee OA. This double-blind randomized clinical trial was performed on 62 patients with knee OA. The patients were randomly divided into two groups. In the first group 40 mg triamcinolone (1 cc) and in the second group 10 cc (15 μg/ml) oxygen-ozone (O2-O3) were injected into the knee joint under ultrasound guidance. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis (WOMAC), knee flexion range of motion (ROM), effusion in ultrasound images of the suprapatellar recess, and visual analog scale (VAS), which were evaluated before injection, 1 week, 1 month, and 3 months after the treatment. Sixty-two patients (10 men and 52 women) were enrolled with mean age of 57.9 years. VAS improved in both groups (steroid P value = 0.001, oxygen-ozone P value > 0.001). The improvements seen in VAS and WOMAC scores 3 months after treatment were in favor of the oxygen-ozone group when compared to the steroid group (P = 0.041 vs P = 0.19). There was no significant difference between the two groups in ROM and joint effusion seen under ultrasound (ROM p = 0.880, effusion p = 0.362). However, in the oxygen-ozone-receiving group, joint effusion was decreased significantly (p < 0.001). Both steroid and oxygen-ozone injections are effective in patients with knee osteoarthritis. Our study showed that the effects of oxygen-ozone injection last longer than those of steroid injection to the knee joint. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/29796866/The_effects_of_ultrasound_guided_corticosteroid_injection_compared_to_oxygen_ozone__O2_O3__injection_in_patients_with_knee_osteoarthritis:_a_randomized_controlled_trial_ L2 - https://dx.doi.org/10.1007/s10067-018-4147-6 DB - PRIME DP - Unbound Medicine ER -