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Tinea capitis in children: a systematic review of management.
J Eur Acad Dermatol Venereol. 2018 Dec; 32(12):2264-2274.JE

Abstract

BACKGROUND

Tinea capitis is the most common cutaneous fungal infection in children.

OBJECTIVES

This review aims to evaluate the differences that exist between medications for the treatment of tinea capitis, to determine whether there are any significant adverse effects associated and to define the usefulness of sample collection methods.

METHODS

We conducted a systematic literature search of available papers using the databases PubMed, OVID, Cochrane Libraries and ClinicalTrials.gov. Twenty-one RCTs and 17 CTs were found.

RESULTS

Among the different antifungal therapies (oral and combination thereof), continuous itraconazole and terbinafine had the highest mycological cure rates (79% and 81%, respectively), griseofulvin and terbinafine had the highest clinical cure rates (46% and 58%, respectively) and griseofulvin and terbinafine had the highest complete cure rate (72% and 92%, respectively). Griseofulvin more effectively treated Microsporum infections; terbinafine and itraconazole more effectively cured Trichophyton infections. Only 1.0% of children had to discontinue medication based on adverse events. T. tonsurans was the most common organism found in North America, and hairbrush collection method is the most efficient method of sample collection. Additionally, using a hairbrush, toothbrush or cotton swab to identify the infecting organism(s) is the least invasive and most efficient method of tinea capitis sample collection in children.

CONCLUSIONS

Current dosing regimens of reported drugs are effective and safe for use in tinea capitis in children.

Authors+Show Affiliations

Mediprobe Research Inc., London, Canada. Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada.Mediprobe Research Inc., London, Canada.Mediprobe Research Inc., London, Canada.Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada. Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, Canada.Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada. Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK. Division of Dermatology, Women's College Hospital, Toronto, Canada.Fredric Brandt endowed professor of Dermatology, University of Miami, Miami, FL, USA.San Diego School of Medicine, University of California, San Diego, CA, USA.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

29797669

Citation

Gupta, A K., et al. "Tinea Capitis in Children: a Systematic Review of Management." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 32, no. 12, 2018, pp. 2264-2274.
Gupta AK, Mays RR, Versteeg SG, et al. Tinea capitis in children: a systematic review of management. J Eur Acad Dermatol Venereol. 2018;32(12):2264-2274.
Gupta, A. K., Mays, R. R., Versteeg, S. G., Piraccini, B. M., Shear, N. H., Piguet, V., Tosti, A., & Friedlander, S. F. (2018). Tinea capitis in children: a systematic review of management. Journal of the European Academy of Dermatology and Venereology : JEADV, 32(12), 2264-2274. https://doi.org/10.1111/jdv.15088
Gupta AK, et al. Tinea Capitis in Children: a Systematic Review of Management. J Eur Acad Dermatol Venereol. 2018;32(12):2264-2274. PubMed PMID: 29797669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tinea capitis in children: a systematic review of management. AU - Gupta,A K, AU - Mays,R R, AU - Versteeg,S G, AU - Piraccini,B M, AU - Shear,N H, AU - Piguet,V, AU - Tosti,A, AU - Friedlander,S F, Y1 - 2018/07/12/ PY - 2018/04/06/received PY - 2018/05/09/accepted PY - 2018/5/26/pubmed PY - 2019/3/15/medline PY - 2018/5/26/entrez SP - 2264 EP - 2274 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 32 IS - 12 N2 - BACKGROUND: Tinea capitis is the most common cutaneous fungal infection in children. OBJECTIVES: This review aims to evaluate the differences that exist between medications for the treatment of tinea capitis, to determine whether there are any significant adverse effects associated and to define the usefulness of sample collection methods. METHODS: We conducted a systematic literature search of available papers using the databases PubMed, OVID, Cochrane Libraries and ClinicalTrials.gov. Twenty-one RCTs and 17 CTs were found. RESULTS: Among the different antifungal therapies (oral and combination thereof), continuous itraconazole and terbinafine had the highest mycological cure rates (79% and 81%, respectively), griseofulvin and terbinafine had the highest clinical cure rates (46% and 58%, respectively) and griseofulvin and terbinafine had the highest complete cure rate (72% and 92%, respectively). Griseofulvin more effectively treated Microsporum infections; terbinafine and itraconazole more effectively cured Trichophyton infections. Only 1.0% of children had to discontinue medication based on adverse events. T. tonsurans was the most common organism found in North America, and hairbrush collection method is the most efficient method of sample collection. Additionally, using a hairbrush, toothbrush or cotton swab to identify the infecting organism(s) is the least invasive and most efficient method of tinea capitis sample collection in children. CONCLUSIONS: Current dosing regimens of reported drugs are effective and safe for use in tinea capitis in children. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/29797669/Tinea_capitis_in_children:_a_systematic_review_of_management_ L2 - https://doi.org/10.1111/jdv.15088 DB - PRIME DP - Unbound Medicine ER -