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[Clinical investigation of basophil activation test as a complementary test for house dust mite allergen].

Abstract

Objective:

To investigate the clinical application of glass micro fiber basophil activation test (BAT) used as a complementary test for house dust mite allergen.Method:Forty patients with clinical diagnosed allergic rhinitis was test by three methods for house dust mite allergen, skin prick test(SPT),Immuno CAP sIgE, and BAT in vitro. The sensitivity and specificity of glass micro fiber were accessed, and the consistency between BAT, SPT, and Immuno sIgE was analyzed. As in vivo provocation was not performed, gold standard is regarded as the combination of medical history and positive reports of SPT and/or ImmunoCAP sIgE test.Result:Twentythree patients are diagnosed as house dust mite allergic rhinitis by gold standard. The sensitivity and specificity of glass micro fiber BAT were 60.9% and 88.2%, the sensitivity of SPT and sIgE was 87.0% and sIgE 73.9%. The correlation rates between BAT with SPT is 0.67(P<0.05), and sIgE 0.55(P<0.05). The accuracy, predictive value of positive and negative of BAT are 0.47,60.9%,88.2%.The Kappa values of BAT, SPT and sIgE with gold standard are 0.47,0.86,0.71.

Conclusion:

As a complementary test for house dust mite allergic rhinitis, BAT have a good consistency with SPT and sIgE, while as it has only moderate consistency with "gold standard", further studies are needed to prove its clinical significance.

Authors+Show Affiliations

Department of Otolaryngology, Beijing Electric Power Hospital, State Grid Corporation of China, Beijing, 100073, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29798295

Citation

Ren, H L., et al. "[Clinical Investigation of Basophil Activation Test as a Complementary Test for House Dust Mite Allergen]." Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery, vol. 32, no. 5, 2018, pp. 365-368.
Ren HL, Li JD, Miao YH, et al. [Clinical investigation of basophil activation test as a complementary test for house dust mite allergen]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;32(5):365-368.
Ren, H. L., Li, J. D., Miao, Y. H., & Xu, T. (2018). [Clinical investigation of basophil activation test as a complementary test for house dust mite allergen]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery, 32(5), 365-368. https://doi.org/10.13201/j.issn.1001-1781.2018.05.011
Ren HL, et al. [Clinical Investigation of Basophil Activation Test as a Complementary Test for House Dust Mite Allergen]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;32(5):365-368. PubMed PMID: 29798295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical investigation of basophil activation test as a complementary test for house dust mite allergen]. AU - Ren,H L, AU - Li,J D, AU - Miao,Y H, AU - Xu,T, PY - 2017/11/23/received PY - 2018/5/26/entrez PY - 2018/5/26/pubmed PY - 2018/10/20/medline KW - allergen KW - basophil activation tests KW - house dust mite KW - specific immunoglobulin E SP - 365 EP - 368 JF - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery JO - Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi VL - 32 IS - 5 N2 - Objective:To investigate the clinical application of glass micro fiber basophil activation test (BAT) used as a complementary test for house dust mite allergen.Method:Forty patients with clinical diagnosed allergic rhinitis was test by three methods for house dust mite allergen, skin prick test(SPT),Immuno CAP sIgE, and BAT in vitro. The sensitivity and specificity of glass micro fiber were accessed, and the consistency between BAT, SPT, and Immuno sIgE was analyzed. As in vivo provocation was not performed, gold standard is regarded as the combination of medical history and positive reports of SPT and/or ImmunoCAP sIgE test.Result:Twentythree patients are diagnosed as house dust mite allergic rhinitis by gold standard. The sensitivity and specificity of glass micro fiber BAT were 60.9% and 88.2%, the sensitivity of SPT and sIgE was 87.0% and sIgE 73.9%. The correlation rates between BAT with SPT is 0.67(P<0.05), and sIgE 0.55(P<0.05). The accuracy, predictive value of positive and negative of BAT are 0.47,60.9%,88.2%.The Kappa values of BAT, SPT and sIgE with gold standard are 0.47,0.86,0.71.Conclusion:As a complementary test for house dust mite allergic rhinitis, BAT have a good consistency with SPT and sIgE, while as it has only moderate consistency with "gold standard", further studies are needed to prove its clinical significance. SN - 1001-1781 UR - https://www.unboundmedicine.com/medline/citation/29798295/[Clinical_investigation_of_basophil_activation_test_as_a_complementary_test_for_house_dust_mite_allergen]_ DB - PRIME DP - Unbound Medicine ER -