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[Clinical evaluations of anterior cruciate ligament reconstruction with platelet rich plasma].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 04 15; 31(4):410-416.ZX

Abstract

Objective

To investigate the clinical outcomes of autologous platelet rich plasma (PRP) for anterior cruciate ligament (ACL) reconstruction.

Methods

Between August 2014 and August 2016, 42 patients with ACL ruptures who underwent arthroscopic ACL reconstruction were randomly divided into 2 groups: 21 patients received graft soaked with PRP (trial group) and 21 patients received routine graft in ACL reconstruction (control group). Because 6 patients failed to be followed up, 17 patients of trial group and 19 of control group were enrolled in the study. There was no significant difference in gender, age, body mass index, side, injury reason, disease duration, Kellgren-Lawrence grade, and preoperative visual analogue scale (VAS), Lysholm score, and International Knee Documentation Committee (IKDC) activity scores between 2 groups (P>0.05). VAS score, Lysholm score, and IKDC activity scores were used to evaluate pain and function at 3 and 12 months postoperatively. Further, second arthroscopy and MRI examination were performed at 12 months postoperatively.

Results

The patients in both groups were followed up 3 to 12 months with an average of 9.83 months. The VAS score, Lysholm score, and IKDC activity scores were significantly improved at 3 and 12 months after operation in 2 groups (P<0.05), and the scores of trial group were significantly better than those of control group at 3 months (P<0.05), but no significant difference was found between 2 groups at 12 months (P>0.05). No complications of effusion, infection, and allergy were observed in 2 groups during follow-up. MRI showed good position of ACL grafts and good signal quality of the graft in the majority of the cases. However, mixed hyperintense and presence of synovial fluid at the femoral bone-tendon graft interface were found in 3 patients of trial group and 4 patients of control group, indicating poor remodeling ligamentation. MRI score was 3.53±1.13 in trial group and was 3.21±0.92 in control group, showing no significant difference (t=0.936, P=0.356). The second arthroscopy examination showed ligament remodeling score was higher in trial group than control group (t=3.248, P=0.014), but no significant difference was found in synovial coverage score and the incidence of cartilage repair (t=2.190, P=0.064; χ2=0.090, P=0.764).

Conclusion

PRP application in allograft ACL reconstruction can improve knee function and relieve pain after operation, which may also accelerate graft remodeling.

Authors+Show Affiliations

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun Jilin, 130033, P.R.China.Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun Jilin, 130033, P.R.China.Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun Jilin, 130033, P.R.China.Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun Jilin, 130033, P.R.China.Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun Jilin, 130033, P.R.China.Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun Jilin, 130033, P.R.China.qingweiyu77@126.com.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29798604

Citation

Ji, Qingming, et al. "[Clinical Evaluations of Anterior Cruciate Ligament Reconstruction With Platelet Rich Plasma]." Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery, vol. 31, no. 4, 2017, pp. 410-416.
Ji Q, Yang Y, Chen H, et al. [Clinical evaluations of anterior cruciate ligament reconstruction with platelet rich plasma]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017;31(4):410-416.
Ji, Q., Yang, Y., Chen, H., Geng, W., Dong, H., & Yu, Q. (2017). [Clinical evaluations of anterior cruciate ligament reconstruction with platelet rich plasma]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery, 31(4), 410-416. https://doi.org/10.7507/1002-1892.201611056
Ji Q, et al. [Clinical Evaluations of Anterior Cruciate Ligament Reconstruction With Platelet Rich Plasma]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 04 15;31(4):410-416. PubMed PMID: 29798604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical evaluations of anterior cruciate ligament reconstruction with platelet rich plasma]. AU - Ji,Qingming, AU - Yang,Yuhui, AU - Chen,Hao, AU - Geng,Weizheng, AU - Dong,Hang, AU - Yu,Qingwei, PY - 2018/5/26/entrez PY - 2018/5/26/pubmed PY - 2018/6/28/medline KW - Platelet rich plasma KW - anterior cruciate ligament reconstruction KW - arthroscopy KW - hamstring autograft SP - 410 EP - 416 JF - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery JO - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi VL - 31 IS - 4 N2 - Objective: To investigate the clinical outcomes of autologous platelet rich plasma (PRP) for anterior cruciate ligament (ACL) reconstruction. Methods: Between August 2014 and August 2016, 42 patients with ACL ruptures who underwent arthroscopic ACL reconstruction were randomly divided into 2 groups: 21 patients received graft soaked with PRP (trial group) and 21 patients received routine graft in ACL reconstruction (control group). Because 6 patients failed to be followed up, 17 patients of trial group and 19 of control group were enrolled in the study. There was no significant difference in gender, age, body mass index, side, injury reason, disease duration, Kellgren-Lawrence grade, and preoperative visual analogue scale (VAS), Lysholm score, and International Knee Documentation Committee (IKDC) activity scores between 2 groups (P>0.05). VAS score, Lysholm score, and IKDC activity scores were used to evaluate pain and function at 3 and 12 months postoperatively. Further, second arthroscopy and MRI examination were performed at 12 months postoperatively. Results: The patients in both groups were followed up 3 to 12 months with an average of 9.83 months. The VAS score, Lysholm score, and IKDC activity scores were significantly improved at 3 and 12 months after operation in 2 groups (P<0.05), and the scores of trial group were significantly better than those of control group at 3 months (P<0.05), but no significant difference was found between 2 groups at 12 months (P>0.05). No complications of effusion, infection, and allergy were observed in 2 groups during follow-up. MRI showed good position of ACL grafts and good signal quality of the graft in the majority of the cases. However, mixed hyperintense and presence of synovial fluid at the femoral bone-tendon graft interface were found in 3 patients of trial group and 4 patients of control group, indicating poor remodeling ligamentation. MRI score was 3.53±1.13 in trial group and was 3.21±0.92 in control group, showing no significant difference (t=0.936, P=0.356). The second arthroscopy examination showed ligament remodeling score was higher in trial group than control group (t=3.248, P=0.014), but no significant difference was found in synovial coverage score and the incidence of cartilage repair (t=2.190, P=0.064; χ2=0.090, P=0.764). Conclusion: PRP application in allograft ACL reconstruction can improve knee function and relieve pain after operation, which may also accelerate graft remodeling. SN - 1002-1892 UR - https://www.unboundmedicine.com/medline/citation/29798604/[Clinical_evaluations_of_anterior_cruciate_ligament_reconstruction_with_platelet_rich_plasma]_ L2 - https://medlineplus.gov/kneeinjuriesanddisorders.html DB - PRIME DP - Unbound Medicine ER -