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Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released from Cells.
Anal Chem. 2018 06 19; 90(12):7158-7163.AC

Abstract

We developed a simple and environmentally friendly ultraviolet (UV)-irradiation-assisted technique to fabricate a stretchable, nanostructured gold film as a flexible electrode for the detection of NO release. The flexible gold film endows the electrode with desirable electrochemical stability against mechanical deformation, including bending to different curvatures and bearing repeated bending circumstances (200 times). The flexible nanostructured gold electrodes can catalyze NO oxidation at 0.85 V (as opposed to Ag/AgCl) and detect NO within a wide linearity in the range of 10 nM to 1.295 μM. Its excellent NO-sensing ability and its stretchability together with its biocompatibility allows the electrode to electrochemically monitor NO release from mechanically sensitive HUVECs in both their unstretched and stretched states. This result paves the way for an effective and easily accessible platform for designing stretchable and flexible electrodes and opens more opportunities for sensing chemical-signal molecules released from cells or other biological samples during mechanical stimulation.

Authors+Show Affiliations

Department of Chemistry , Capital Normal University , Beijing 100048 , China.Department of Chemistry , Capital Normal University , Beijing 100048 , China.Department of Chemistry , Capital Normal University , Beijing 100048 , China.Department of Chemistry , Capital Normal University , Beijing 100048 , China.Department of Chemistry , Capital Normal University , Beijing 100048 , China.Department of Chemistry , Capital Normal University , Beijing 100048 , China.Beijing National Laboratory for Molecular Sciences , Institute of Chemistry, Chinese Academy of Sciences (CAS) , Beijing 100190 , China.Department of Chemistry , Capital Normal University , Beijing 100048 , China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29799730

Citation

Zhao, Xu, et al. "Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released From Cells." Analytical Chemistry, vol. 90, no. 12, 2018, pp. 7158-7163.
Zhao X, Wang K, Li B, et al. Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released from Cells. Anal Chem. 2018;90(12):7158-7163.
Zhao, X., Wang, K., Li, B., Wang, C., Ding, Y., Li, C., Mao, L., & Lin, Y. (2018). Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released from Cells. Analytical Chemistry, 90(12), 7158-7163. https://doi.org/10.1021/acs.analchem.8b01088
Zhao X, et al. Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released From Cells. Anal Chem. 2018 06 19;90(12):7158-7163. PubMed PMID: 29799730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released from Cells. AU - Zhao,Xu, AU - Wang,Keqing, AU - Li,Bo, AU - Wang,Chao, AU - Ding,Yongqi, AU - Li,Changqing, AU - Mao,Lanqun, AU - Lin,Yuqing, Y1 - 2018/06/06/ PY - 2018/5/26/pubmed PY - 2019/4/24/medline PY - 2018/5/26/entrez SP - 7158 EP - 7163 JF - Analytical chemistry JO - Anal. Chem. VL - 90 IS - 12 N2 - We developed a simple and environmentally friendly ultraviolet (UV)-irradiation-assisted technique to fabricate a stretchable, nanostructured gold film as a flexible electrode for the detection of NO release. The flexible gold film endows the electrode with desirable electrochemical stability against mechanical deformation, including bending to different curvatures and bearing repeated bending circumstances (200 times). The flexible nanostructured gold electrodes can catalyze NO oxidation at 0.85 V (as opposed to Ag/AgCl) and detect NO within a wide linearity in the range of 10 nM to 1.295 μM. Its excellent NO-sensing ability and its stretchability together with its biocompatibility allows the electrode to electrochemically monitor NO release from mechanically sensitive HUVECs in both their unstretched and stretched states. This result paves the way for an effective and easily accessible platform for designing stretchable and flexible electrodes and opens more opportunities for sensing chemical-signal molecules released from cells or other biological samples during mechanical stimulation. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/29799730/Fabrication_of_a_Flexible_and_Stretchable_Nanostructured_Gold_Electrode_Using_a_Facile_Ultraviolet_Irradiation_Approach_for_the_Detection_of_Nitric_Oxide_Released_from_Cells_ L2 - https://dx.doi.org/10.1021/acs.analchem.8b01088 DB - PRIME DP - Unbound Medicine ER -