Tags

Type your tag names separated by a space and hit enter

Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies.
Carbohydr Polym 2018; 194:311-318CP

Abstract

The sequential optimization of carboxymethylation of pectin by Plackett-Burman (PB) design and response surface methodology (RSM) was reported in this study. PB design was employed to screen the six process variables (ethanol concentration, liquid-polymer ratio, NaOH concentration, CAA concentration, temperature and time). Central composite design (CCD) was used to study the interaction effects of ethanol concentration, NaOH concentration, CAA concentration and time on degree of substitution (DS) in carboxymethylated pectin (CMP). Maximum DS value of 0.496 was predicted at ethanol concentration (80%), NaOH concentration (38%), CAA concentration (8.5%) and time (60 min). The synthesized CMP was characterized by FT-IR, XRD, TGA and viscometer. Results of FTIR, XRD and TGA confirmed the modification made in the pectin polymer and highly methylated. Faster release of 5-FU drug was observed with CMP-chitosan nanoparticles as compared to pectin-chitosan nanoparticles and the drug release followed zero order kinetics model.

Authors+Show Affiliations

Department of Industrial Biotechnology, Government College of Technology, Coimbatore 641013, Tamilnadu, India. Electronic address: muthukumaran.c@gct.ac.in.Department of Industrial Biotechnology, Government College of Technology, Coimbatore 641013, Tamilnadu, India.Department of Industrial Biotechnology, Government College of Technology, Coimbatore 641013, Tamilnadu, India.Department of Genetic Engineering, SRM University, Kattankulathur 603203, Tamilnadu, India.Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641049, Tamilnadu, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29801844

Citation

C, Muthukumaran, et al. "Carboxymethylation of Pectin: Optimization, Characterization and In-vitro Drug Release Studies." Carbohydrate Polymers, vol. 194, 2018, pp. 311-318.
C M, B R K, G S, et al. Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies. Carbohydr Polym. 2018;194:311-318.
C, M., B R, K., G, S., N, M. K., & M, S. (2018). Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies. Carbohydrate Polymers, 194, pp. 311-318. doi:10.1016/j.carbpol.2018.04.042.
C M, et al. Carboxymethylation of Pectin: Optimization, Characterization and In-vitro Drug Release Studies. Carbohydr Polym. 2018 Aug 15;194:311-318. PubMed PMID: 29801844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies. AU - C,Muthukumaran, AU - B R,Kanmani, AU - G,Sharmila, AU - N,Manoj Kumar, AU - M,Shanmugaprakash, Y1 - 2018/04/14/ PY - 2018/01/30/received PY - 2018/03/22/revised PY - 2018/04/10/accepted PY - 2018/5/27/entrez PY - 2018/5/29/pubmed PY - 2018/10/4/medline KW - Carboxymethylation KW - Optimization KW - PBD KW - Pectin KW - RSM SP - 311 EP - 318 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 194 N2 - The sequential optimization of carboxymethylation of pectin by Plackett-Burman (PB) design and response surface methodology (RSM) was reported in this study. PB design was employed to screen the six process variables (ethanol concentration, liquid-polymer ratio, NaOH concentration, CAA concentration, temperature and time). Central composite design (CCD) was used to study the interaction effects of ethanol concentration, NaOH concentration, CAA concentration and time on degree of substitution (DS) in carboxymethylated pectin (CMP). Maximum DS value of 0.496 was predicted at ethanol concentration (80%), NaOH concentration (38%), CAA concentration (8.5%) and time (60 min). The synthesized CMP was characterized by FT-IR, XRD, TGA and viscometer. Results of FTIR, XRD and TGA confirmed the modification made in the pectin polymer and highly methylated. Faster release of 5-FU drug was observed with CMP-chitosan nanoparticles as compared to pectin-chitosan nanoparticles and the drug release followed zero order kinetics model. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/29801844/Carboxymethylation_of_pectin:_Optimization,_characterization_and_in-vitro_drug_release_studies L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(18)30428-4 DB - PRIME DP - Unbound Medicine ER -