Tags

Type your tag names separated by a space and hit enter

Experimental evidence of dietary ciguatoxin accumulation in an herbivorous coral reef fish.
Aquat Toxicol. 2018 Jul; 200:257-265.AT

Abstract

Ciguatoxins (CTXs) are potent algal toxins that cause widespread ciguatera poisoning and are found ubiquitously in coral reef food webs. Here we developed an environmentally-relevant, experimental model of CTX trophic transfer involving dietary exposure of herbivorous fish to the CTX-producing microalgae Gambierdiscus polynesiensis. Juvenile Naso brevirostris were fed a gel-food embedded with microalgae for 16 weeks (89 cells g-1 fish daily, 0.4 μg CTX3C equiv kg-1 fish). CTXs in muscle tissue were detectable after 2 weeks at levels above the threshold for human intoxication (1.2 ± 0.2 μg CTX3C equiv kg-1). Although tissue CTX concentrations stabilized after 8 weeks (∼3 ± 0.5 μg CTX3C equiv kg-1), muscle toxin burden (total μg CTX in muscle tissue) continued to increase linearly through the end of the experiment (16 weeks). Toxin accumulation was therefore continuous, yet masked by somatic growth dilution. The observed CTX concentrations, accumulation rates, and general absence of behavioural signs of intoxication are consistent with field observations and indicate that this method of dietary exposure may be used to develop predictive models of tissue-specific CTX uptake, metabolism and depuration. Results also imply that slow-growing fish may accumulate higher CTX flesh concentrations than fast-growing fish, which has important implications for global seafood safety.

Authors+Show Affiliations

International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco.International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco.International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco.Institut Louis Malardé- UMR 241 EIO, Laboratoire des Micro-algues Toxiques, BP 30, 98713, Papeete-Tahiti, French Polynesia.Ifremer, Laboratoire Phycotoxines, Rue de l'Ile d'Yeu, 44311, Nantes, France.Ifremer, Laboratoire Phycotoxines, Rue de l'Ile d'Yeu, 44311, Nantes, France.International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco.Institut Louis Malardé- UMR 241 EIO, Laboratoire des Micro-algues Toxiques, BP 30, 98713, Papeete-Tahiti, French Polynesia.International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco. Electronic address: m-y.bottein@iaea.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29803968

Citation

Clausing, Rachel J., et al. "Experimental Evidence of Dietary Ciguatoxin Accumulation in an Herbivorous Coral Reef Fish." Aquatic Toxicology (Amsterdam, Netherlands), vol. 200, 2018, pp. 257-265.
Clausing RJ, Losen B, Oberhaensli FR, et al. Experimental evidence of dietary ciguatoxin accumulation in an herbivorous coral reef fish. Aquat Toxicol. 2018;200:257-265.
Clausing, R. J., Losen, B., Oberhaensli, F. R., Darius, H. T., Sibat, M., Hess, P., Swarzenski, P. W., Chinain, M., & Dechraoui Bottein, M. Y. (2018). Experimental evidence of dietary ciguatoxin accumulation in an herbivorous coral reef fish. Aquatic Toxicology (Amsterdam, Netherlands), 200, 257-265. https://doi.org/10.1016/j.aquatox.2018.05.007
Clausing RJ, et al. Experimental Evidence of Dietary Ciguatoxin Accumulation in an Herbivorous Coral Reef Fish. Aquat Toxicol. 2018;200:257-265. PubMed PMID: 29803968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental evidence of dietary ciguatoxin accumulation in an herbivorous coral reef fish. AU - Clausing,Rachel J, AU - Losen,Barbara, AU - Oberhaensli,Francois R, AU - Darius,H Taiana, AU - Sibat,Manoella, AU - Hess,Philipp, AU - Swarzenski,Peter W, AU - Chinain,Mireille, AU - Dechraoui Bottein,Marie-Yasmine, Y1 - 2018/05/26/ PY - 2018/02/05/received PY - 2018/05/08/revised PY - 2018/05/09/accepted PY - 2018/5/29/pubmed PY - 2018/7/26/medline PY - 2018/5/28/entrez KW - Bioaccumulation KW - Ciguatoxin KW - Experimental model KW - Growth dilution KW - Herbivorous fish KW - Trophic transfer SP - 257 EP - 265 JF - Aquatic toxicology (Amsterdam, Netherlands) JO - Aquat Toxicol VL - 200 N2 - Ciguatoxins (CTXs) are potent algal toxins that cause widespread ciguatera poisoning and are found ubiquitously in coral reef food webs. Here we developed an environmentally-relevant, experimental model of CTX trophic transfer involving dietary exposure of herbivorous fish to the CTX-producing microalgae Gambierdiscus polynesiensis. Juvenile Naso brevirostris were fed a gel-food embedded with microalgae for 16 weeks (89 cells g-1 fish daily, 0.4 μg CTX3C equiv kg-1 fish). CTXs in muscle tissue were detectable after 2 weeks at levels above the threshold for human intoxication (1.2 ± 0.2 μg CTX3C equiv kg-1). Although tissue CTX concentrations stabilized after 8 weeks (∼3 ± 0.5 μg CTX3C equiv kg-1), muscle toxin burden (total μg CTX in muscle tissue) continued to increase linearly through the end of the experiment (16 weeks). Toxin accumulation was therefore continuous, yet masked by somatic growth dilution. The observed CTX concentrations, accumulation rates, and general absence of behavioural signs of intoxication are consistent with field observations and indicate that this method of dietary exposure may be used to develop predictive models of tissue-specific CTX uptake, metabolism and depuration. Results also imply that slow-growing fish may accumulate higher CTX flesh concentrations than fast-growing fish, which has important implications for global seafood safety. SN - 1879-1514 UR - https://www.unboundmedicine.com/medline/citation/29803968/Experimental_evidence_of_dietary_ciguatoxin_accumulation_in_an_herbivorous_coral_reef_fish_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-445X(18)30090-0 DB - PRIME DP - Unbound Medicine ER -