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Diffusion MRI parameters of corpus callosum and corticospinal tract in neonates: Comparison between region-of-interest and whole tract averaged measurements.
Eur J Paediatr Neurol. 2018 Sep; 22(5):807-813.EJ

Abstract

PURPOSE

Measures of white matter (WM) microstructure inferred from diffusion magnetic resonance imaging (dMRI) are useful for studying brain development. There is uncertainty about agreement between FA and MD values obtained from region-of-interest (ROI) versus whole tract approaches. We investigated agreement between dMRI measures using ROI and Probabilistic Neighbourhood Tractography (PNT) in genu of corpus callosum (gCC) and corticospinal tracts (CST).

MATERIALS AND METHODS

81 neonates underwent 64 direction DTI at term equivalent age. FA and MD values were extracted from a 8 mm3 ROI placed within the gCC, right and left posterior limbs of internal capsule. PNT was used to segment gCC and CSTs to calculate whole tract-averaged FA and MD. Agreement between values obtained by each method was compared using Bland-Altman statistics and Pearson's correlation.

RESULTS

Across the 3 tracts the mean difference in FA measured by PNT and ROI ranged between 0.13 and 0.17, and the 95% limits of agreement did not include the possibility of no difference. For MD, the mean difference in values obtained from PNT and ROI ranged between 0.101 and 0.184 mm2/s × 10-3 mm2/s: the mean difference in gCC was 0.101 × 10-3 mm2/s with 95% limits of agreement that included the possibility of no difference, but there was significant disagreement in MD values measured in the CSTs.

CONCLUSION

Agreement between dMRI measures of neonatal WM microstructure calculated from ROI and whole tract averaged methods is weak. ROI approaches may not provide sufficient representation of tract microstructure at the level of neural systems in newborns.

Authors+Show Affiliations

MRC Centre for Reproductive Health, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.Centre for Clinical Brain Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.University/BHF Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.MRC Centre for Reproductive Health, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.MRC Centre for Reproductive Health, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.MRC Centre for Reproductive Health, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; University/BHF Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.University/BHF Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; Clinical Research Imaging Centre, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.Centre for Clinical Brain Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.MRC Centre for Reproductive Health, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; Centre for Clinical Brain Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address: james.boardman@ed.ac.uk.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29804802

Citation

Sparrow, Sarah A., et al. "Diffusion MRI Parameters of Corpus Callosum and Corticospinal Tract in Neonates: Comparison Between Region-of-interest and Whole Tract Averaged Measurements." European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, vol. 22, no. 5, 2018, pp. 807-813.
Sparrow SA, Anblagan D, Drake AJ, et al. Diffusion MRI parameters of corpus callosum and corticospinal tract in neonates: Comparison between region-of-interest and whole tract averaged measurements. Eur J Paediatr Neurol. 2018;22(5):807-813.
Sparrow, S. A., Anblagan, D., Drake, A. J., Telford, E. J., Pataky, R., Piyasena, C., Semple, S. I., Bastin, M. E., & Boardman, J. P. (2018). Diffusion MRI parameters of corpus callosum and corticospinal tract in neonates: Comparison between region-of-interest and whole tract averaged measurements. European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, 22(5), 807-813. https://doi.org/10.1016/j.ejpn.2018.05.003
Sparrow SA, et al. Diffusion MRI Parameters of Corpus Callosum and Corticospinal Tract in Neonates: Comparison Between Region-of-interest and Whole Tract Averaged Measurements. Eur J Paediatr Neurol. 2018;22(5):807-813. PubMed PMID: 29804802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion MRI parameters of corpus callosum and corticospinal tract in neonates: Comparison between region-of-interest and whole tract averaged measurements. AU - Sparrow,Sarah A, AU - Anblagan,Devasuda, AU - Drake,Amanda J, AU - Telford,Emma J, AU - Pataky,Rozalia, AU - Piyasena,Chinthika, AU - Semple,Scott I, AU - Bastin,Mark E, AU - Boardman,James P, Y1 - 2018/05/16/ PY - 2017/07/27/received PY - 2018/03/28/revised PY - 2018/05/11/accepted PY - 2018/5/29/pubmed PY - 2018/12/12/medline PY - 2018/5/29/entrez KW - Corpus callosum KW - Corticospinal KW - Diffusion KW - Neonatal KW - Region-of-interest KW - Tractography SP - 807 EP - 813 JF - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society JO - Eur. J. Paediatr. Neurol. VL - 22 IS - 5 N2 - PURPOSE: Measures of white matter (WM) microstructure inferred from diffusion magnetic resonance imaging (dMRI) are useful for studying brain development. There is uncertainty about agreement between FA and MD values obtained from region-of-interest (ROI) versus whole tract approaches. We investigated agreement between dMRI measures using ROI and Probabilistic Neighbourhood Tractography (PNT) in genu of corpus callosum (gCC) and corticospinal tracts (CST). MATERIALS AND METHODS: 81 neonates underwent 64 direction DTI at term equivalent age. FA and MD values were extracted from a 8 mm3 ROI placed within the gCC, right and left posterior limbs of internal capsule. PNT was used to segment gCC and CSTs to calculate whole tract-averaged FA and MD. Agreement between values obtained by each method was compared using Bland-Altman statistics and Pearson's correlation. RESULTS: Across the 3 tracts the mean difference in FA measured by PNT and ROI ranged between 0.13 and 0.17, and the 95% limits of agreement did not include the possibility of no difference. For MD, the mean difference in values obtained from PNT and ROI ranged between 0.101 and 0.184 mm2/s × 10-3 mm2/s: the mean difference in gCC was 0.101 × 10-3 mm2/s with 95% limits of agreement that included the possibility of no difference, but there was significant disagreement in MD values measured in the CSTs. CONCLUSION: Agreement between dMRI measures of neonatal WM microstructure calculated from ROI and whole tract averaged methods is weak. ROI approaches may not provide sufficient representation of tract microstructure at the level of neural systems in newborns. SN - 1532-2130 UR - https://www.unboundmedicine.com/medline/citation/29804802/Diffusion_MRI_parameters_of_corpus_callosum_and_corticospinal_tract_in_neonates:_Comparison_between_region_of_interest_and_whole_tract_averaged_measurements_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3798(17)31778-6 DB - PRIME DP - Unbound Medicine ER -