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Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review.
J Immunol Res 2018; 2018:6936727JI

Abstract

IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved.

Authors+Show Affiliations

Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.Otorhinolaryngology Unit, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Cagliari, Italy.Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.Otorhinolaryngology Unit, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Cagliari, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29805984

Citation

Puxeddu, Ilaria, et al. "Salivary Gland Pathology in IgG4-Related Disease: a Comprehensive Review." Journal of Immunology Research, vol. 2018, 2018, p. 6936727.
Puxeddu I, Capecchi R, Carta F, et al. Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review. J Immunol Res. 2018;2018:6936727.
Puxeddu, I., Capecchi, R., Carta, F., Tavoni, A. G., Migliorini, P., & Puxeddu, R. (2018). Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review. Journal of Immunology Research, 2018, p. 6936727. doi:10.1155/2018/6936727.
Puxeddu I, et al. Salivary Gland Pathology in IgG4-Related Disease: a Comprehensive Review. J Immunol Res. 2018;2018:6936727. PubMed PMID: 29805984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review. AU - Puxeddu,Ilaria, AU - Capecchi,Riccardo, AU - Carta,Filippo, AU - Tavoni,Antonio Gaetano, AU - Migliorini,Paola, AU - Puxeddu,Roberto, Y1 - 2018/04/01/ PY - 2018/01/12/received PY - 2018/03/05/accepted PY - 2018/5/29/entrez PY - 2018/5/29/pubmed PY - 2018/9/15/medline SP - 6936727 EP - 6936727 JF - Journal of immunology research JO - J Immunol Res VL - 2018 N2 - IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved. SN - 2314-7156 UR - https://www.unboundmedicine.com/medline/citation/29805984/Salivary_Gland_Pathology_in_IgG4_Related_Disease:_A_Comprehensive_Review_ L2 - https://dx.doi.org/10.1155/2018/6936727 DB - PRIME DP - Unbound Medicine ER -