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Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis.
J Int Med Res. 2018 Sep; 46(9):3596-3604.JI

Abstract

Objective This study was performed to investigate the role of probiotics (Clostridium butyricum combined with Bifidobacterium infantis) in the treatment of minimal hepatic encephalopathy (MHE) in patients with hepatitis B virus (HBV)-induced liver cirrhosis. Methods Sixty-seven consecutive patients with HBV-induced cirrhosis without overt hepatic encephalopathy were screened using the number connection test and digit symbol test. The patients were randomized to receive probiotics (n = 30) or no probiotics (n = 37) for 3 months. At the end of the trial, changes in cognition, intestinal microbiota, venous ammonia, and intestinal mucosal barriers were analyzed using recommended systems biology techniques. Results The patients' cognition was significantly improved after probiotic treatment. The predominant bacteria (Clostridium cluster I and Bifidobacterium) were significantly enriched in the probiotics-treated group, while Enterococcus and Enterobacteriaceae were significantly decreased. Probiotic treatment was also associated with an obvious reduction in venous ammonia. Additionally, the parameters of the intestinal mucosal barrier were obviously improved after probiotic treatment, which might have contributed to the improved cognition and the decreased ammonia levels. Conclusion Treatment with probiotics containing C. butyricum and B. infantis represents a new adjuvant therapy for the management of MHE in patients with HBV-induced cirrhosis.

Authors+Show Affiliations

1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.1 Department of Infectious Diseases, Changxing People's Hospital, Huzhou, Zhejiang, China.2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29806520

Citation

Xia, Xiaoxue, et al. "Role of Probiotics in the Treatment of Minimal Hepatic Encephalopathy in Patients With HBV-induced Liver Cirrhosis." The Journal of International Medical Research, vol. 46, no. 9, 2018, pp. 3596-3604.
Xia X, Chen J, Xia J, et al. Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis. J Int Med Res. 2018;46(9):3596-3604.
Xia, X., Chen, J., Xia, J., Wang, B., Liu, H., Yang, L., Wang, Y., & Ling, Z. (2018). Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis. The Journal of International Medical Research, 46(9), 3596-3604. https://doi.org/10.1177/0300060518776064
Xia X, et al. Role of Probiotics in the Treatment of Minimal Hepatic Encephalopathy in Patients With HBV-induced Liver Cirrhosis. J Int Med Res. 2018;46(9):3596-3604. PubMed PMID: 29806520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis. AU - Xia,Xiaoxue, AU - Chen,Jiang, AU - Xia,Jiayun, AU - Wang,Bin, AU - Liu,Hua, AU - Yang,Ling, AU - Wang,Ying, AU - Ling,Zongxin, Y1 - 2018/05/28/ PY - 2018/5/29/pubmed PY - 2019/4/9/medline PY - 2018/5/29/entrez KW - Bifidobacterium KW - Clostridium KW - Minimal hepatic encephalopathy KW - hepatitis B virus KW - liver cirrhosis KW - probiotics SP - 3596 EP - 3604 JF - The Journal of international medical research JO - J Int Med Res VL - 46 IS - 9 N2 - Objective This study was performed to investigate the role of probiotics (Clostridium butyricum combined with Bifidobacterium infantis) in the treatment of minimal hepatic encephalopathy (MHE) in patients with hepatitis B virus (HBV)-induced liver cirrhosis. Methods Sixty-seven consecutive patients with HBV-induced cirrhosis without overt hepatic encephalopathy were screened using the number connection test and digit symbol test. The patients were randomized to receive probiotics (n = 30) or no probiotics (n = 37) for 3 months. At the end of the trial, changes in cognition, intestinal microbiota, venous ammonia, and intestinal mucosal barriers were analyzed using recommended systems biology techniques. Results The patients' cognition was significantly improved after probiotic treatment. The predominant bacteria (Clostridium cluster I and Bifidobacterium) were significantly enriched in the probiotics-treated group, while Enterococcus and Enterobacteriaceae were significantly decreased. Probiotic treatment was also associated with an obvious reduction in venous ammonia. Additionally, the parameters of the intestinal mucosal barrier were obviously improved after probiotic treatment, which might have contributed to the improved cognition and the decreased ammonia levels. Conclusion Treatment with probiotics containing C. butyricum and B. infantis represents a new adjuvant therapy for the management of MHE in patients with HBV-induced cirrhosis. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/29806520/Role_of_probiotics_in_the_treatment_of_minimal_hepatic_encephalopathy_in_patients_with_HBV_induced_liver_cirrhosis_ L2 - https://journals.sagepub.com/doi/10.1177/0300060518776064?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -