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An Update on Calciphylaxis.
Am J Clin Dermatol. 2018 Aug; 19(4):599-608.AJ

Abstract

Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial wall calcification and intimal hyperplasia, is a multifactorial cutaneous vascular disease characterized by chronic, painful, non-healing wounds that occur frequently in patients with chronic kidney disease, predominantly in those with end-stage renal disease. The pathogenesis remains unclear, and the development of calciphylaxis lesions depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion. Despite an increase in reports of calciphylaxis in the literature and clinical recognition of demographic characteristics and risk factors associated with calciphylaxis, it remains a poorly understood disease with high morbidity and mortality. In this review, we analyze and summarize the clinical manifestations, pathogenesis and pathophysiology, histopathology, differential diagnosis, diagnostic workup and treatment modalities for calciphylaxis. Because of the lack of consensus regarding the optimal approach to and treatment of this disorder, a high degree of clinical suspicion, early diagnosis, and multimodal and multidisciplinary treatment in collaboration with dermatology, nephrology, wound care, nutrition and pain management specialties may improve survival in patients with calciphylaxis.

Authors+Show Affiliations

Department of Dermatology, University Hospital "Dr. José Eleuterio González", Autonomous University of Nuevo León, Av. Madero y Gonzalitos S/N 64460 Col. Mitras Centro, Monterrey, Mexico.Department of Dermatology, University Hospital "Dr. José Eleuterio González", Autonomous University of Nuevo León, Av. Madero y Gonzalitos S/N 64460 Col. Mitras Centro, Monterrey, Mexico.Department of Dermatology, University Hospital "Dr. José Eleuterio González", Autonomous University of Nuevo León, Av. Madero y Gonzalitos S/N 64460 Col. Mitras Centro, Monterrey, Mexico.Department of Dermatology, University Hospital "Dr. José Eleuterio González", Autonomous University of Nuevo León, Av. Madero y Gonzalitos S/N 64460 Col. Mitras Centro, Monterrey, Mexico. verogarzardz@hotmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29808451

Citation

García-Lozano, José Alberto, et al. "An Update On Calciphylaxis." American Journal of Clinical Dermatology, vol. 19, no. 4, 2018, pp. 599-608.
García-Lozano JA, Ocampo-Candiani J, Martínez-Cabriales SA, et al. An Update on Calciphylaxis. Am J Clin Dermatol. 2018;19(4):599-608.
García-Lozano, J. A., Ocampo-Candiani, J., Martínez-Cabriales, S. A., & Garza-Rodríguez, V. (2018). An Update on Calciphylaxis. American Journal of Clinical Dermatology, 19(4), 599-608. https://doi.org/10.1007/s40257-018-0361-x
García-Lozano JA, et al. An Update On Calciphylaxis. Am J Clin Dermatol. 2018;19(4):599-608. PubMed PMID: 29808451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Update on Calciphylaxis. AU - García-Lozano,José Alberto, AU - Ocampo-Candiani,Jorge, AU - Martínez-Cabriales,Sylvia Aide, AU - Garza-Rodríguez,Verónica, PY - 2018/5/29/pubmed PY - 2018/11/15/medline PY - 2018/5/30/entrez SP - 599 EP - 608 JF - American journal of clinical dermatology JO - Am J Clin Dermatol VL - 19 IS - 4 N2 - Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial wall calcification and intimal hyperplasia, is a multifactorial cutaneous vascular disease characterized by chronic, painful, non-healing wounds that occur frequently in patients with chronic kidney disease, predominantly in those with end-stage renal disease. The pathogenesis remains unclear, and the development of calciphylaxis lesions depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion. Despite an increase in reports of calciphylaxis in the literature and clinical recognition of demographic characteristics and risk factors associated with calciphylaxis, it remains a poorly understood disease with high morbidity and mortality. In this review, we analyze and summarize the clinical manifestations, pathogenesis and pathophysiology, histopathology, differential diagnosis, diagnostic workup and treatment modalities for calciphylaxis. Because of the lack of consensus regarding the optimal approach to and treatment of this disorder, a high degree of clinical suspicion, early diagnosis, and multimodal and multidisciplinary treatment in collaboration with dermatology, nephrology, wound care, nutrition and pain management specialties may improve survival in patients with calciphylaxis. SN - 1179-1888 UR - https://www.unboundmedicine.com/medline/citation/29808451/An_Update_on_Calciphylaxis_ L2 - https://dx.doi.org/10.1007/s40257-018-0361-x DB - PRIME DP - Unbound Medicine ER -
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