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Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes.
Gynecol Endocrinol. 2018 Nov; 34(11):987-994.GE

Abstract

Objective: This systematic review and meta-analysis of Spanish studies assessed the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal outcomes. Methods: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of Science research databases were searched from inception through December 30 2017 using the terms 'vitamin D', 'pregnancy', and 'Spain'. Studies that compared first or second half of pregnancy normal 25(OH)D (≥30.0 ng/mL) versus insufficient (20.0-29.9 ng/mL) or deficient (<20.0 ng/mL) circulating levels and perinatal outcomes were systematically extracted. Data are presented as pooled odds ratios and their 95% confidence intervals (CIs) for categorical variables or mean differences and CIs for continuous variables. Risk of bias was evaluated with the Newcastle-Ottawa Scale. Results: Five cohort studies met inclusion criteria. The risk of gestational diabetes mellitus, preeclampsia, preterm birth, and small-for-gestational-age infants, and birthweight was not influenced by first half of pregnancy maternal 25(OH)D levels. In addition, second half of pregnancy 25(OH) levels did not affect birthweight. Conclusion: Maternal 25(OH)D levels during pregnancy did not affect studied perinatal outcomes and birthweight.

Authors+Show Affiliations

a Facultad de Medicina , Universidad de Zaragoza , Zaragoza , Spain.a Facultad de Medicina , Universidad de Zaragoza , Zaragoza , Spain. b Obstetrics Service , Miguel Servet University Hospital , Zaragoza , Spain.c Institute of Biomedicine, Research Area for Women's Health, Facultad de Ciencias Médicas , Universidad Católica de Santiago de Guayaquil , Guayaquil , Ecuador. d Facultad de Ciencias de la Salud , Universidad Católica "Nuestra Señora de la Asunción" , Asunción , Paraguay.a Facultad de Medicina , Universidad de Zaragoza , Zaragoza , Spain. e Department of Obstetrics and Gynecology , Lozano-Blesa University Hospital , Zaragoza , Spain.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29842806

Citation

Martínez-Domínguez, Samuel J., et al. "Systematic Review and Meta-analysis of Spanish Studies Regarding the Association Between Maternal 25-hydroxyvitamin D Levels and Perinatal Outcomes." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 34, no. 11, 2018, pp. 987-994.
Martínez-Domínguez SJ, Tajada M, Chedraui P, et al. Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes. Gynecol Endocrinol. 2018;34(11):987-994.
Martínez-Domínguez, S. J., Tajada, M., Chedraui, P., & Pérez-López, F. R. (2018). Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 34(11), 987-994. https://doi.org/10.1080/09513590.2018.1472761
Martínez-Domínguez SJ, et al. Systematic Review and Meta-analysis of Spanish Studies Regarding the Association Between Maternal 25-hydroxyvitamin D Levels and Perinatal Outcomes. Gynecol Endocrinol. 2018;34(11):987-994. PubMed PMID: 29842806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes. AU - Martínez-Domínguez,Samuel J, AU - Tajada,Mauricio, AU - Chedraui,Peter, AU - Pérez-López,Faustino R, Y1 - 2018/05/29/ PY - 2018/5/31/pubmed PY - 2019/9/29/medline PY - 2018/5/30/entrez KW - 25-hydroxyvitamin D KW - Preeclampsia KW - birthweight KW - gestational diabetes mellitus KW - preterm birth KW - small-for-gestational-age KW - vitamin D SP - 987 EP - 994 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 34 IS - 11 N2 - Objective: This systematic review and meta-analysis of Spanish studies assessed the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal outcomes. Methods: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of Science research databases were searched from inception through December 30 2017 using the terms 'vitamin D', 'pregnancy', and 'Spain'. Studies that compared first or second half of pregnancy normal 25(OH)D (≥30.0 ng/mL) versus insufficient (20.0-29.9 ng/mL) or deficient (<20.0 ng/mL) circulating levels and perinatal outcomes were systematically extracted. Data are presented as pooled odds ratios and their 95% confidence intervals (CIs) for categorical variables or mean differences and CIs for continuous variables. Risk of bias was evaluated with the Newcastle-Ottawa Scale. Results: Five cohort studies met inclusion criteria. The risk of gestational diabetes mellitus, preeclampsia, preterm birth, and small-for-gestational-age infants, and birthweight was not influenced by first half of pregnancy maternal 25(OH)D levels. In addition, second half of pregnancy 25(OH) levels did not affect birthweight. Conclusion: Maternal 25(OH)D levels during pregnancy did not affect studied perinatal outcomes and birthweight. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/29842806/Systematic_review_and_meta_analysis_of_Spanish_studies_regarding_the_association_between_maternal_25_hydroxyvitamin_D_levels_and_perinatal_outcomes_ DB - PRIME DP - Unbound Medicine ER -