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Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease.
J Orthop Surg Res. 2018 May 29; 13(1):128.JO

Abstract

BACKGROUND

Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers. The serum level of PIICP, PIIANP, and PIIBNP can specifically reflect the damage of the cartilage. So, in this study, the serum levels of PIICP, PIIANP, and PIIBNP were detected in order to determine whether they can be used as potential biomarkers for the diagnosis of KBD.

METHOD

Using a status survey, the survey sites were selected in the KBD historical endemic areas and non-endemic areas in Jilin and Heilongjiang provinces. All local residents have undergone clinical examination, X-ray examination of the hands and knees, and questionnaire survey. A total of 554 people were surveyed, and 184 residents who are eligible for inclusion criteria were selected as our subjects. Fifty-six cases were diagnosed as KBD and 63 individuals were included as internal control and 65 subjects were included as external control. And blood samples of surveyed subjects were collected, and the serum was separated to detect the levels of PIICP, PIIANP, and PIIBNP by ELISA. Statistical analysis was performed using the SPSS software.

RESULTS

There were no statistically significant differences in age and sex among the three groups. The Kruskal-Wallis H test showed that the serum levels of PIICP, PIIANP, and PIIBNP were significantly different among the three groups. Multiple comparisons using Dunnett's T3 test revealed that serum levels of PIICP, PIIANP, and PIIBNP were significantly lower in KBD patients than in internal and external control. However, there was no significant difference between the internal and external control.

CONCLUSIONS

The results preliminarily indicated that the levels of PIICP, PIIANP, and PIIBNP in serum could reflect the abnormal synthesis of type II collagen in KBD patients and suggested that these indicators might be used as potential biomarkers for the diagnosis of KBD.

Authors+Show Affiliations

Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China.Jilin Institute of Endemic Disease Prevention Second, Jilin, China.Jilin Institute of Endemic Disease Prevention Second, Jilin, China.Jilin Institute of Endemic Disease Prevention Second, Jilin, China.Jilin Institute of Endemic Disease Prevention Second, Jilin, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China. 6yujun@126.com. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, China. 6yujun@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29843748

Citation

Lian, Wei, et al. "Serum Levels of PIICP, PIIANP, and PIIBNP Are Decreased in Patients With an Endemic Osteochondropathy, Kashin-Beck Disease." Journal of Orthopaedic Surgery and Research, vol. 13, no. 1, 2018, p. 128.
Lian W, Liu H, Sun LY, et al. Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease. J Orthop Surg Res. 2018;13(1):128.
Lian, W., Liu, H., Sun, L. Y., Liu, Y. Q., Cui, S. L., Wang, Y., Song, Q. Q., Deng, Q., Wang, S. P., Cao, Y. H., Zhang, X. Y., Jiang, Y. Y., Lv, H. Y., Duan, L. B., & Yu, J. (2018). Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease. Journal of Orthopaedic Surgery and Research, 13(1), 128. https://doi.org/10.1186/s13018-018-0840-z
Lian W, et al. Serum Levels of PIICP, PIIANP, and PIIBNP Are Decreased in Patients With an Endemic Osteochondropathy, Kashin-Beck Disease. J Orthop Surg Res. 2018 May 29;13(1):128. PubMed PMID: 29843748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease. AU - Lian,Wei, AU - Liu,Hui, AU - Sun,Li Yan, AU - Liu,Yun Qi, AU - Cui,Si Lu, AU - Wang,Yue, AU - Song,Quan Quan, AU - Deng,Qing, AU - Wang,Shao Ping, AU - Cao,Yan Hong, AU - Zhang,Xue Ying, AU - Jiang,Yuan Yuan, AU - Lv,Hong Yan, AU - Duan,Li Bin, AU - Yu,Jun, Y1 - 2018/05/29/ PY - 2017/12/15/received PY - 2018/05/21/accepted PY - 2018/5/31/entrez PY - 2018/5/31/pubmed PY - 2018/10/9/medline KW - Biomarkers KW - Kashin-Beck disease KW - PIIANP KW - PIIBNP KW - PIICP KW - Type II collagen SP - 128 EP - 128 JF - Journal of orthopaedic surgery and research JO - J Orthop Surg Res VL - 13 IS - 1 N2 - BACKGROUND: Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers. The serum level of PIICP, PIIANP, and PIIBNP can specifically reflect the damage of the cartilage. So, in this study, the serum levels of PIICP, PIIANP, and PIIBNP were detected in order to determine whether they can be used as potential biomarkers for the diagnosis of KBD. METHOD: Using a status survey, the survey sites were selected in the KBD historical endemic areas and non-endemic areas in Jilin and Heilongjiang provinces. All local residents have undergone clinical examination, X-ray examination of the hands and knees, and questionnaire survey. A total of 554 people were surveyed, and 184 residents who are eligible for inclusion criteria were selected as our subjects. Fifty-six cases were diagnosed as KBD and 63 individuals were included as internal control and 65 subjects were included as external control. And blood samples of surveyed subjects were collected, and the serum was separated to detect the levels of PIICP, PIIANP, and PIIBNP by ELISA. Statistical analysis was performed using the SPSS software. RESULTS: There were no statistically significant differences in age and sex among the three groups. The Kruskal-Wallis H test showed that the serum levels of PIICP, PIIANP, and PIIBNP were significantly different among the three groups. Multiple comparisons using Dunnett's T3 test revealed that serum levels of PIICP, PIIANP, and PIIBNP were significantly lower in KBD patients than in internal and external control. However, there was no significant difference between the internal and external control. CONCLUSIONS: The results preliminarily indicated that the levels of PIICP, PIIANP, and PIIBNP in serum could reflect the abnormal synthesis of type II collagen in KBD patients and suggested that these indicators might be used as potential biomarkers for the diagnosis of KBD. SN - 1749-799X UR - https://www.unboundmedicine.com/medline/citation/29843748/Serum_levels_of_PIICP_PIIANP_and_PIIBNP_are_decreased_in_patients_with_an_endemic_osteochondropathy_Kashin_Beck_disease_ L2 - https://josr-online.biomedcentral.com/articles/10.1186/s13018-018-0840-z DB - PRIME DP - Unbound Medicine ER -