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Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management.
Curr Allergy Asthma Rep. 2018 05 29; 18(7):37.CA

Abstract

PURPOSE OF REVIEW

Pediatric chronic rhinosinusitis (CRS) is a common disorder that carries significant morbidity. The diagnosis requires sinus symptoms that persist despite standard medical therapy greater than 3 months. Viral infections, allergies, and anatomic differences in children lead to chronic obstruction of the osteomeatal complex.

RECENT FINDINGS

Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex. New survey studies provide some consensus on prevalence and management of this disease in children. In this review, we highlight the differential diagnosis of pediatric CRS, including non-eosinophilic/infectious variants, eosinophilic variants with and without nasal polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease, primary immunodeficiency, and disorders of mucociliary clearance. Further, we detail treatment options that should be considered. Finally, we feature emerging potential treatment options of CRS, including anti-immunoglobulin E, interleukin-5, and interleukin-4 receptor alpha subunit.

Authors+Show Affiliations

Boone Hospital Center, Columbia, MO, USA.Department of Otolaryngology, Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. kennedyjoshual@uams.edu. Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA. kennedyjoshual@uams.edu. Arkansas Children's Research Institute, 13 Children's Way, Slot 512-13, Little Rock, AR, 72202, USA. kennedyjoshual@uams.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29845321

Citation

Heath, Jordan, et al. "Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management." Current Allergy and Asthma Reports, vol. 18, no. 7, 2018, p. 37.
Heath J, Hartzell L, Putt C, et al. Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management. Curr Allergy Asthma Rep. 2018;18(7):37.
Heath, J., Hartzell, L., Putt, C., & Kennedy, J. L. (2018). Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management. Current Allergy and Asthma Reports, 18(7), 37. https://doi.org/10.1007/s11882-018-0792-8
Heath J, et al. Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management. Curr Allergy Asthma Rep. 2018 05 29;18(7):37. PubMed PMID: 29845321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management. AU - Heath,Jordan, AU - Hartzell,Larry, AU - Putt,Claire, AU - Kennedy,Joshua L, Y1 - 2018/05/29/ PY - 2018/5/31/entrez PY - 2018/5/31/pubmed PY - 2019/6/18/medline KW - Monoclonal antibodies KW - Mucociliary clearance KW - Nasal polyps KW - Osteomeatal complex KW - Pediatric chronic rhinosinusitis KW - Treatment of pediatric chronic rhinosinusitis SP - 37 EP - 37 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 18 IS - 7 N2 - PURPOSE OF REVIEW: Pediatric chronic rhinosinusitis (CRS) is a common disorder that carries significant morbidity. The diagnosis requires sinus symptoms that persist despite standard medical therapy greater than 3 months. Viral infections, allergies, and anatomic differences in children lead to chronic obstruction of the osteomeatal complex. RECENT FINDINGS: Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex. New survey studies provide some consensus on prevalence and management of this disease in children. In this review, we highlight the differential diagnosis of pediatric CRS, including non-eosinophilic/infectious variants, eosinophilic variants with and without nasal polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease, primary immunodeficiency, and disorders of mucociliary clearance. Further, we detail treatment options that should be considered. Finally, we feature emerging potential treatment options of CRS, including anti-immunoglobulin E, interleukin-5, and interleukin-4 receptor alpha subunit. SN - 1534-6315 UR - https://www.unboundmedicine.com/medline/citation/29845321/Chronic_Rhinosinusitis_in_Children:_Pathophysiology_Evaluation_and_Medical_Management_ L2 - https://dx.doi.org/10.1007/s11882-018-0792-8 DB - PRIME DP - Unbound Medicine ER -