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Prevalence and spectrum of symptomatic pulmonary involvement in primary Sjögren's syndrome.
Clin Exp Rheumatol. 2018 May-Jun; 36 Suppl 112(3):94-101.CE

Abstract

OBJECTIVES

The present cross-sectional study aimed to estimate the prevalence of chronic respiratory symptoms in primary Sjögren's syndrome (pSS) and define the clinical, functional and imaging characteristics of symptomatic pulmonary disease in pSS.

METHODS

Four hundred and fourteen consecutive pSS patients were interviewed for the presence of chronic respiratory complaints (cough and/or dyspnea). Symptomatic pSS patients without respiratory or other comorbidities underwent further investigation with clinical evaluation and assessment with pulmonary functional testing (PFTs) and chest high resolution CT (hrCT) on inspiratory and expiratory phase. Comparison of clinical and laboratory features between symptomatic and asymptomatic pSS patients was also performed.

RESULTS

Prevalence of chronic respiratory symptoms in pSS was estimated at 21.5% (89/414). Symptoms were attributed to underlying comorbidities in approximately one third of cases (30/89). Thirty nine of the remaining 59 patients were finally assessed with PFTs and hrCT. Small airway disease was diagnosed in 20 individuals with an obstructive pattern in PFTs and/or compatible radiological signs. Seven patients were diagnosed with interstitial lung disease, while in the remaining 12 pSS patients, with normal PFTs and hrCT, symptoms were attributed to xerotrachea. Raynaud's phenomenon occurred more frequently in symptomatic than asymptomatic patients (p=0.024).

CONCLUSIONS

Approximately one fifth of a large cohort of pSS patients presented chronic respiratory symptoms. Small airway disease was the most commonly recognized pulmonary disorder among symptomatic pSS patients, followed by xerotrachea and interstitial lung disease.

Authors+Show Affiliations

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece. chkamp77@gmail.com.Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Greece.Department of Pathophysiology, and Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Greece.Department of Radiology, "Laiko" General Hospital, Athens, Greece."Evgenidion Clinic Agia Trias", Respiratory Department, Athens, Greece.Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29846161

Citation

Kampolis, Christos F., et al. "Prevalence and Spectrum of Symptomatic Pulmonary Involvement in Primary Sjögren's Syndrome." Clinical and Experimental Rheumatology, vol. 36 Suppl 112, no. 3, 2018, pp. 94-101.
Kampolis CF, Fragkioudaki S, Mavragani CP, et al. Prevalence and spectrum of symptomatic pulmonary involvement in primary Sjögren's syndrome. Clin Exp Rheumatol. 2018;36 Suppl 112(3):94-101.
Kampolis, C. F., Fragkioudaki, S., Mavragani, C. P., Zormpala, A., Samakovli, A., & Moutsopoulos, H. M. (2018). Prevalence and spectrum of symptomatic pulmonary involvement in primary Sjögren's syndrome. Clinical and Experimental Rheumatology, 36 Suppl 112(3), 94-101.
Kampolis CF, et al. Prevalence and Spectrum of Symptomatic Pulmonary Involvement in Primary Sjögren's Syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):94-101. PubMed PMID: 29846161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and spectrum of symptomatic pulmonary involvement in primary Sjögren's syndrome. AU - Kampolis,Christos F, AU - Fragkioudaki,Sofia, AU - Mavragani,Clio P, AU - Zormpala,Alexandra, AU - Samakovli,Anastasia, AU - Moutsopoulos,Haralampos M, Y1 - 2018/05/29/ PY - 2018/01/03/received PY - 2018/03/26/accepted PY - 2018/5/31/pubmed PY - 2018/11/27/medline PY - 2018/5/31/entrez SP - 94 EP - 101 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 36 Suppl 112 IS - 3 N2 - OBJECTIVES: The present cross-sectional study aimed to estimate the prevalence of chronic respiratory symptoms in primary Sjögren's syndrome (pSS) and define the clinical, functional and imaging characteristics of symptomatic pulmonary disease in pSS. METHODS: Four hundred and fourteen consecutive pSS patients were interviewed for the presence of chronic respiratory complaints (cough and/or dyspnea). Symptomatic pSS patients without respiratory or other comorbidities underwent further investigation with clinical evaluation and assessment with pulmonary functional testing (PFTs) and chest high resolution CT (hrCT) on inspiratory and expiratory phase. Comparison of clinical and laboratory features between symptomatic and asymptomatic pSS patients was also performed. RESULTS: Prevalence of chronic respiratory symptoms in pSS was estimated at 21.5% (89/414). Symptoms were attributed to underlying comorbidities in approximately one third of cases (30/89). Thirty nine of the remaining 59 patients were finally assessed with PFTs and hrCT. Small airway disease was diagnosed in 20 individuals with an obstructive pattern in PFTs and/or compatible radiological signs. Seven patients were diagnosed with interstitial lung disease, while in the remaining 12 pSS patients, with normal PFTs and hrCT, symptoms were attributed to xerotrachea. Raynaud's phenomenon occurred more frequently in symptomatic than asymptomatic patients (p=0.024). CONCLUSIONS: Approximately one fifth of a large cohort of pSS patients presented chronic respiratory symptoms. Small airway disease was the most commonly recognized pulmonary disorder among symptomatic pSS patients, followed by xerotrachea and interstitial lung disease. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/29846161/Prevalence_and_spectrum_of_symptomatic_pulmonary_involvement_in_primary_Sjögren's_syndrome_ L2 - http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=29846161 DB - PRIME DP - Unbound Medicine ER -