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Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults.
JAMA Psychiatry. 2018 07 01; 75(7):697-703.JP

Abstract

Importance

Associations between late-life participation in intellectual activities and decreased odds of developing dementia have been reported. However, reverse causality and confounding effects due to other health behaviors or problems have not been adequately addressed.

Objective

To examine whether late-life participation in intellectual activities is associated with a lower risk of incident dementia years later, independent of other lifestyle and health-related factors.

Design, Setting, and Participants

A longitudinal observational study was conducted at all Elderly Health Centres of the Department of Health of the Government of Hong Kong among 15 582 community-living Chinese individuals age 65 years or older at baseline who were free of dementia, with baseline evaluations performed January 1 to June 30, 2005, and follow-up assessments performed from January 1, 2006, to December 31, 2012. Statistical analysis was performed from January 1, 2015, to December 31, 2016.

Main Outcomes and Measures

The main outcome was incident dementia as diagnosed by geriatric psychiatrists in accordance with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, or a Clinical Dementia Rating of 1 to 3. At baseline and follow-up interviews, self-reported information on participation in intellectual activities within 1 month before assessment was collected. Examples of intellectual activities, which were described by a local validated classification system, were reading books, newspapers, or magazines; playing board games, Mahjong, or card games; and betting on horse racing. Other important variables including demographics (age, sex, and educational level), physical and psychiatric comorbidities (cardiovascular risks, depression, visual and hearing impairments, and poor mobility), and lifestyle factors (physical exercise, adequate fruit and vegetable intake, smoking, and recreational and social activities) were also assessed.

Results

Of the 15 582 individuals in the study, 9950 (63.9%) were women, and the median age at baseline was 74 years (interquartile range, 71-77 years). A total of 1349 individuals (8.7%) developed dementia during a median follow-up period of 5.0 years. Multivariable logistic regression analysis showed that the estimated odds ratio for incident dementia was 0.71 (95% CI, 0.60-0.84; P < .001) for those with intellectual activities at baseline, after excluding those who developed dementia within 3 years after baseline and adjusting for health behaviors, physical and psychiatric comorbidities, and sociodemographic factors.

Conclusions and Relevance

Active participation in intellectual activities, even in late life, might help delay or prevent dementia in older adults.

Authors+Show Affiliations

Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.Medical Research Council Unit for Lifelong Health and Ageing, University College London, London, United Kingdom.Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China.Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.Elderly Health Service, Department of Health, The Government of Hong Kong SAR, Hong Kong SAR, China.Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29847678

Citation

Lee, Allen T C., et al. "Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults." JAMA Psychiatry, vol. 75, no. 7, 2018, pp. 697-703.
Lee ATC, Richards M, Chan WC, et al. Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults. JAMA Psychiatry. 2018;75(7):697-703.
Lee, A. T. C., Richards, M., Chan, W. C., Chiu, H. F. K., Lee, R. S. Y., & Lam, L. C. W. (2018). Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults. JAMA Psychiatry, 75(7), 697-703. https://doi.org/10.1001/jamapsychiatry.2018.0657
Lee ATC, et al. Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults. JAMA Psychiatry. 2018 07 1;75(7):697-703. PubMed PMID: 29847678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults. AU - Lee,Allen T C, AU - Richards,Marcus, AU - Chan,Wai C, AU - Chiu,Helen F K, AU - Lee,Ruby S Y, AU - Lam,Linda C W, PY - 2018/5/31/pubmed PY - 2019/10/17/medline PY - 2018/5/31/entrez SP - 697 EP - 703 JF - JAMA psychiatry JO - JAMA Psychiatry VL - 75 IS - 7 N2 - Importance: Associations between late-life participation in intellectual activities and decreased odds of developing dementia have been reported. However, reverse causality and confounding effects due to other health behaviors or problems have not been adequately addressed. Objective: To examine whether late-life participation in intellectual activities is associated with a lower risk of incident dementia years later, independent of other lifestyle and health-related factors. Design, Setting, and Participants: A longitudinal observational study was conducted at all Elderly Health Centres of the Department of Health of the Government of Hong Kong among 15 582 community-living Chinese individuals age 65 years or older at baseline who were free of dementia, with baseline evaluations performed January 1 to June 30, 2005, and follow-up assessments performed from January 1, 2006, to December 31, 2012. Statistical analysis was performed from January 1, 2015, to December 31, 2016. Main Outcomes and Measures: The main outcome was incident dementia as diagnosed by geriatric psychiatrists in accordance with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, or a Clinical Dementia Rating of 1 to 3. At baseline and follow-up interviews, self-reported information on participation in intellectual activities within 1 month before assessment was collected. Examples of intellectual activities, which were described by a local validated classification system, were reading books, newspapers, or magazines; playing board games, Mahjong, or card games; and betting on horse racing. Other important variables including demographics (age, sex, and educational level), physical and psychiatric comorbidities (cardiovascular risks, depression, visual and hearing impairments, and poor mobility), and lifestyle factors (physical exercise, adequate fruit and vegetable intake, smoking, and recreational and social activities) were also assessed. Results: Of the 15 582 individuals in the study, 9950 (63.9%) were women, and the median age at baseline was 74 years (interquartile range, 71-77 years). A total of 1349 individuals (8.7%) developed dementia during a median follow-up period of 5.0 years. Multivariable logistic regression analysis showed that the estimated odds ratio for incident dementia was 0.71 (95% CI, 0.60-0.84; P < .001) for those with intellectual activities at baseline, after excluding those who developed dementia within 3 years after baseline and adjusting for health behaviors, physical and psychiatric comorbidities, and sociodemographic factors. Conclusions and Relevance: Active participation in intellectual activities, even in late life, might help delay or prevent dementia in older adults. SN - 2168-6238 UR - https://www.unboundmedicine.com/medline/citation/29847678/Association_of_Daily_Intellectual_Activities_With_Lower_Risk_of_Incident_Dementia_Among_Older_Chinese_Adults_ DB - PRIME DP - Unbound Medicine ER -