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Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial.
Eur J Clin Nutr. 2018 07; 72(7):961-970.EJ

Abstract

BACKGROUND/OBJECTIVES

A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes.

SUBJECTS/METHODS

Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale.

RESULTS

A total of 192 women were included. As the hot flush diaries from one study centre were lost, the assessment of hot flushes was based on 136 participants (soy: 54 women; placebo: 82 women). After 12 weeks, 180 women were available for the analysis of Greene Scale and safety (soy and placebo: each 90 women). Hot flushes were reduced by 43.3% (-3.5 hot flushes) with soy and by 30.8% with placebo (-2.6; p < 0.001). After the open treatment phase with soy, both original groups showed a reduction of 68% of hot flushes. A subgroup analysis showed better effects for soy when symptoms were classified as "severe" at baseline. After 12 weeks of double-blind treatment, there was an improvement from baseline values of 71 and 78% with soy with the items "hot flushes" and "sweating", compared with 24% for both items with placebo. Hormonal safety parameters remained uninfluenced.

CONCLUSIONS

Soy germ extract with 100 mg of isoflavone glycosides was shown to modestly, but significantly reduce menopausal hot flushes.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Univ.-Doz. Dr. med. Martin Imhof, Landesklinikum Weinviertel, Wiener Ring 3-5, A-2100, Korneuburg, Austria.Dr. med. Anca Gocan, Ärztezentrum Rahlgasse, Rahlgasse 1/12, A-1060, Wien, Austria.Dr. Marianne Imhof, Life Research Technologies GmbH, Schönlanterngasse 11/13, A-1010, Wien, Austria.Dr. Mathias Schmidt, Herbresearch Germany, Wartbergweg 15, 86874, Mattsies, Germany. schmidt@herbresearch.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29849181

Citation

Imhof, Martin, et al. "Soy Germ Extract Alleviates Menopausal Hot Flushes: Placebo-controlled Double-blind Trial." European Journal of Clinical Nutrition, vol. 72, no. 7, 2018, pp. 961-970.
Imhof M, Gocan A, Imhof M, et al. Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial. Eur J Clin Nutr. 2018;72(7):961-970.
Imhof, M., Gocan, A., Imhof, M., & Schmidt, M. (2018). Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial. European Journal of Clinical Nutrition, 72(7), 961-970. https://doi.org/10.1038/s41430-018-0173-3
Imhof M, et al. Soy Germ Extract Alleviates Menopausal Hot Flushes: Placebo-controlled Double-blind Trial. Eur J Clin Nutr. 2018;72(7):961-970. PubMed PMID: 29849181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial. AU - Imhof,Martin, AU - Gocan,Anca, AU - Imhof,Marianne, AU - Schmidt,Mathias, Y1 - 2018/05/30/ PY - 2017/08/04/received PY - 2018/04/03/accepted PY - 2018/03/07/revised PY - 2018/6/1/pubmed PY - 2019/5/2/medline PY - 2018/6/1/entrez SP - 961 EP - 970 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 72 IS - 7 N2 - BACKGROUND/OBJECTIVES: A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes. SUBJECTS/METHODS: Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale. RESULTS: A total of 192 women were included. As the hot flush diaries from one study centre were lost, the assessment of hot flushes was based on 136 participants (soy: 54 women; placebo: 82 women). After 12 weeks, 180 women were available for the analysis of Greene Scale and safety (soy and placebo: each 90 women). Hot flushes were reduced by 43.3% (-3.5 hot flushes) with soy and by 30.8% with placebo (-2.6; p < 0.001). After the open treatment phase with soy, both original groups showed a reduction of 68% of hot flushes. A subgroup analysis showed better effects for soy when symptoms were classified as "severe" at baseline. After 12 weeks of double-blind treatment, there was an improvement from baseline values of 71 and 78% with soy with the items "hot flushes" and "sweating", compared with 24% for both items with placebo. Hormonal safety parameters remained uninfluenced. CONCLUSIONS: Soy germ extract with 100 mg of isoflavone glycosides was shown to modestly, but significantly reduce menopausal hot flushes. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/29849181/Soy_germ_extract_alleviates_menopausal_hot_flushes:_placebo_controlled_double_blind_trial_ L2 - http://dx.doi.org/10.1038/s41430-018-0173-3 DB - PRIME DP - Unbound Medicine ER -