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Decoration of 1-D nano bioactive glass on reduced graphene oxide sheets: Strategies and in vitro bioactivity studies.

Abstract

45S5 Bioglass® is the most widely studied class of bioceramic in the field of dental and orthopedics. The present study highlights, one-dimensional bioactive glass nanorods (BGNR) of 45S5 composition synthesized by tuning the parameters of sol-gel process and hybridized with two-dimensional reduced graphene oxide sheets (rGO). BGNR was integrated with rGO by three different methods to form nano hybrids of rGO/BGNR. The prepared BGNR revealed combeite high mineral phase (Na5.27Ca3Si6O18) whereas nano hybrids exhibited calcite mineral phase (CaCO3) along with combeite in XRD analysis. The morphology, size of BGNR and integration of BGNR with rGO were analyzed using SEM. Nano hybrids were subjected to biological characterizations to identify the bio-activity (mineralization), antibacterial efficacy, hemocompatibility and cell proliferation efficacies. These studies conclude that the one-dimensional BGNR, micron-sized reduced graphene oxide sheet and the calcite phase in nano hybrids play a crucial role in enhancing the bioactivity, antibacterial activity, hemocompatibility and cell proliferation. These findings suggest the synergistic effect of rGO/BGNR nano hybrids will open new venue for biomaterials in the field of implant materials.

Authors+Show Affiliations

National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600025, India.National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600025, India. Electronic address: balasuga@yahoo.com.National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600025, India.National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600025, India.Corrosion Science and Technology Division, Materials Characterization Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102, India.Corrosion Science and Technology Division, Materials Characterization Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102, India.Heavy Water Board, Anushakthi Nagar, Mumbai 400 094, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29853151

Citation

C, Ashok Raja, et al. "Decoration of 1-D Nano Bioactive Glass On Reduced Graphene Oxide Sheets: Strategies and in Vitro Bioactivity Studies." Materials Science & Engineering. C, Materials for Biological Applications, vol. 90, 2018, pp. 85-94.
C AR, S B, P B, et al. Decoration of 1-D nano bioactive glass on reduced graphene oxide sheets: Strategies and in vitro bioactivity studies. Mater Sci Eng C Mater Biol Appl. 2018;90:85-94.
C, A. R., S, B., P, B., P, R., B, A., R P, G., & U, K. M. (2018). Decoration of 1-D nano bioactive glass on reduced graphene oxide sheets: Strategies and in vitro bioactivity studies. Materials Science & Engineering. C, Materials for Biological Applications, 90, pp. 85-94. doi:10.1016/j.msec.2018.04.040.
C AR, et al. Decoration of 1-D Nano Bioactive Glass On Reduced Graphene Oxide Sheets: Strategies and in Vitro Bioactivity Studies. Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:85-94. PubMed PMID: 29853151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decoration of 1-D nano bioactive glass on reduced graphene oxide sheets: Strategies and in vitro bioactivity studies. AU - C,Ashok Raja, AU - S,Balakumar, AU - P,Bargavi, AU - P,Rajashree, AU - B,Anandkumar, AU - R P,George, AU - U,Kamachi Mudali, Y1 - 2018/04/17/ PY - 2017/09/09/received PY - 2018/03/20/revised PY - 2018/04/15/accepted PY - 2018/6/2/entrez PY - 2018/6/2/pubmed PY - 2018/10/3/medline KW - Bioactive glass KW - Biomaterials KW - Nano hybrids KW - Reduced graphene oxide KW - Sol-gel SP - 85 EP - 94 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 90 N2 - 45S5 Bioglass® is the most widely studied class of bioceramic in the field of dental and orthopedics. The present study highlights, one-dimensional bioactive glass nanorods (BGNR) of 45S5 composition synthesized by tuning the parameters of sol-gel process and hybridized with two-dimensional reduced graphene oxide sheets (rGO). BGNR was integrated with rGO by three different methods to form nano hybrids of rGO/BGNR. The prepared BGNR revealed combeite high mineral phase (Na5.27Ca3Si6O18) whereas nano hybrids exhibited calcite mineral phase (CaCO3) along with combeite in XRD analysis. The morphology, size of BGNR and integration of BGNR with rGO were analyzed using SEM. Nano hybrids were subjected to biological characterizations to identify the bio-activity (mineralization), antibacterial efficacy, hemocompatibility and cell proliferation efficacies. These studies conclude that the one-dimensional BGNR, micron-sized reduced graphene oxide sheet and the calcite phase in nano hybrids play a crucial role in enhancing the bioactivity, antibacterial activity, hemocompatibility and cell proliferation. These findings suggest the synergistic effect of rGO/BGNR nano hybrids will open new venue for biomaterials in the field of implant materials. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/29853151/Decoration_of_1-D_nano_bioactive_glass_on_reduced_graphene_oxide_sheets:_Strategies_and_in_vitro_bioactivity_studies L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(17)33642-1 DB - PRIME DP - Unbound Medicine ER -