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Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis.
Mediators Inflamm. 2018; 2018:9602362.MI

Abstract

Although fungal colonization is implicated in the pathogenesis of psoriasis, its prevalence remains unclear. The aim of this systematic review and meta-analysis was to provide an overview on the prevalence of Candida species in patients with psoriasis. We searched databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and http://clinicaltrials.gov) to identify studies involving subjects of any age with an established diagnosis of psoriasis and healthy controls, who were tested for carriage of Candida spp. on the skin or mucosal membranes (or saliva and stool), or presented with clinical candidiasis with microbiologically confirmed etiology. We identified nine cross-sectional studies including a total of 1038 subjects with psoriasis (psoriatics) and 669 controls. We found Candida species detection rates for psoriatics were significantly higher than those in the controls, especially in the oral mucosa milieux. These results suggest psoriasis may be one of the systemic diseases that predispose to oral Candida spp. carriage and infection.

Authors+Show Affiliations

Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Ul. Radziwillowska 13, 20-080 Lublin, Poland.Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Ul. Chodźki 4a, 20-093 Lublin, Poland.Department of Internal Medicine and Cardiology, First Military Clinical Hospital with the Outpatient Clinic, Al. Racławickie 23, 20-048 Lublin, Poland.Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Ul. Chodźki 4a, 20-093 Lublin, Poland.Department of Surgical Oncology, Medical University of Lublin, Ul. Staszica 11, 20-081 Lublin, Poland.Department of Dermatology, Medical University of Warsaw, Ul. Koszykowa 82a, 02-008 Warsaw, Poland.Chair and Department of Jaw Orthopaedics, Medical University of Lublin, Ul. Karmelicka 7, 20-081 Lublin, Poland.Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Ul. Radziwillowska 13, 20-080 Lublin, Poland.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

29853795

Citation

Pietrzak, Aldona, et al. "Prevalence and Possible Role of Candida Species in Patients With Psoriasis: a Systematic Review and Meta-Analysis." Mediators of Inflammation, vol. 2018, 2018, p. 9602362.
Pietrzak A, Grywalska E, Socha M, et al. Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis. Mediators Inflamm. 2018;2018:9602362.
Pietrzak, A., Grywalska, E., Socha, M., Roliński, J., Franciszkiewicz-Pietrzak, K., Rudnicka, L., Rudzki, M., & Krasowska, D. (2018). Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis. Mediators of Inflammation, 2018, 9602362. https://doi.org/10.1155/2018/9602362
Pietrzak A, et al. Prevalence and Possible Role of Candida Species in Patients With Psoriasis: a Systematic Review and Meta-Analysis. Mediators Inflamm. 2018;2018:9602362. PubMed PMID: 29853795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis. AU - Pietrzak,Aldona, AU - Grywalska,Ewelina, AU - Socha,Mateusz, AU - Roliński,Jacek, AU - Franciszkiewicz-Pietrzak,Kinga, AU - Rudnicka,Lidia, AU - Rudzki,Marcin, AU - Krasowska,Dorota, Y1 - 2018/05/06/ PY - 2018/01/12/received PY - 2018/04/08/accepted PY - 2018/6/2/entrez PY - 2018/6/2/pubmed PY - 2018/10/3/medline SP - 9602362 EP - 9602362 JF - Mediators of inflammation JO - Mediators Inflamm VL - 2018 N2 - Although fungal colonization is implicated in the pathogenesis of psoriasis, its prevalence remains unclear. The aim of this systematic review and meta-analysis was to provide an overview on the prevalence of Candida species in patients with psoriasis. We searched databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and http://clinicaltrials.gov) to identify studies involving subjects of any age with an established diagnosis of psoriasis and healthy controls, who were tested for carriage of Candida spp. on the skin or mucosal membranes (or saliva and stool), or presented with clinical candidiasis with microbiologically confirmed etiology. We identified nine cross-sectional studies including a total of 1038 subjects with psoriasis (psoriatics) and 669 controls. We found Candida species detection rates for psoriatics were significantly higher than those in the controls, especially in the oral mucosa milieux. These results suggest psoriasis may be one of the systemic diseases that predispose to oral Candida spp. carriage and infection. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/29853795/Prevalence_and_Possible_Role_of_Candida_Species_in_Patients_with_Psoriasis:_A_Systematic_Review_and_Meta_Analysis_ DB - PRIME DP - Unbound Medicine ER -