Tags

Type your tag names separated by a space and hit enter

Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka.
J Clin Neurol 2018; 14(3):339-344JC

Abstract

BACKGROUND AND PURPOSE

The magnetic resonance imaging in multiple sclerosis (MAGNIMS) group recently proposed guidelines to replace the existing dissemination-in-space criteria in McDonald 2010 magnetic resonance imaging (MRI) criteria for diagnosing multiple sclerosis. There has been insufficient research regarding their applicability in Asians. Objective of this study was to determine the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of McDonald 2010 and MAGNIMS 2016 MRI criteria with the aim of verifying their applicability in Sri Lankan patients.

METHODS

Patients with clinically isolated syndrome diagnosed by consultant neurologists were recruited from five major neurology centers. Baseline and follow-up MRI scans were performed within 3 months from the initial presentation and at one year after baseline MRI, respectively. McDonald 2010 and MAGNIMS 2016 MRI criteria were applied to all MRI scans. Patients were followed-up for 2 years to assess the conversion to clinically definite multiple sclerosis (CDMS). The sensitivity, specificity, accuracy, PPV, and NPV for predicting the conversion to CDMS were calculated.

RESULTS

Forty-two of 66 patients converted to CDMS. Thirty-seven fulfilled the McDonald 2010 MRI criteria, and 33 converted to CDMS. MAGNIMS 2016 MRI criteria were fulfilled by 29, with 28 converting to CDMS. The sensitivity, specificity, accuracy, PPV, and NPV were 78%, 83%, 64%, 89%, and 69%, respectively, for the McDonald 2010 criteria, and 67%, 96%, 77%, 96%, and 62% for the MAGNIMS 2016 MRI criteria.

CONCLUSIONS

MAGNIMS 2016 MRI criteria were superior to McDonald 2010 MRI criteria in specificity, accuracy, and PPV, but inferior in sensitivity and NPV.

Authors+Show Affiliations

Department of Anatomy, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.Neurology Unit, Teaching Hospital, Kandy, Sri Lanka.Radiology Unit, Sirimavo Bandaranayaka Specialized Children's Hospital, Peradeniya, Sri Lanka.Department of Anatomy, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.Department of Anatomy, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. ajithsomi@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29856160

Citation

Gamage, Sujani Madhurika Kodagoda, et al. "Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka." Journal of Clinical Neurology (Seoul, Korea), vol. 14, no. 3, 2018, pp. 339-344.
Gamage SMK, Wijeweera I, Wijesinghe P, et al. Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka. J Clin Neurol. 2018;14(3):339-344.
Gamage, S. M. K., Wijeweera, I., Wijesinghe, P., Adikari, S. B., Fink, K., & Sominanda, H. M. A. (2018). Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka. Journal of Clinical Neurology (Seoul, Korea), 14(3), pp. 339-344. doi:10.3988/jcn.2018.14.3.339.
Gamage SMK, et al. Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka. J Clin Neurol. 2018;14(3):339-344. PubMed PMID: 29856160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Applicability of McDonald 2010 and Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) 2016 Magnetic Resonance Imaging Criteria for the Diagnosis of Multiple Sclerosis in Sri Lanka. AU - Gamage,Sujani Madhurika Kodagoda, AU - Wijeweera,Indunil, AU - Wijesinghe,Priyangi, AU - Adikari,Sanjaya Bandara, AU - Fink,Katharina, AU - Sominanda,Herath Mudiyanselage Ajith, Y1 - 2018/05/31/ PY - 2017/12/18/received PY - 2018/03/09/revised PY - 2018/03/12/accepted PY - 2018/6/2/pubmed PY - 2018/6/2/medline PY - 2018/6/2/entrez KW - Asia KW - McDonald 2010 magnetic resonance imaging criteria KW - McDonald 2017 magnetic resonance imaging criteria KW - magnetic resonance imaging in multiple sclerosis 2016 magnetic resonance imaging criteria KW - multiple sclerosis KW - performance SP - 339 EP - 344 JF - Journal of clinical neurology (Seoul, Korea) JO - J Clin Neurol VL - 14 IS - 3 N2 - BACKGROUND AND PURPOSE: The magnetic resonance imaging in multiple sclerosis (MAGNIMS) group recently proposed guidelines to replace the existing dissemination-in-space criteria in McDonald 2010 magnetic resonance imaging (MRI) criteria for diagnosing multiple sclerosis. There has been insufficient research regarding their applicability in Asians. Objective of this study was to determine the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of McDonald 2010 and MAGNIMS 2016 MRI criteria with the aim of verifying their applicability in Sri Lankan patients. METHODS: Patients with clinically isolated syndrome diagnosed by consultant neurologists were recruited from five major neurology centers. Baseline and follow-up MRI scans were performed within 3 months from the initial presentation and at one year after baseline MRI, respectively. McDonald 2010 and MAGNIMS 2016 MRI criteria were applied to all MRI scans. Patients were followed-up for 2 years to assess the conversion to clinically definite multiple sclerosis (CDMS). The sensitivity, specificity, accuracy, PPV, and NPV for predicting the conversion to CDMS were calculated. RESULTS: Forty-two of 66 patients converted to CDMS. Thirty-seven fulfilled the McDonald 2010 MRI criteria, and 33 converted to CDMS. MAGNIMS 2016 MRI criteria were fulfilled by 29, with 28 converting to CDMS. The sensitivity, specificity, accuracy, PPV, and NPV were 78%, 83%, 64%, 89%, and 69%, respectively, for the McDonald 2010 criteria, and 67%, 96%, 77%, 96%, and 62% for the MAGNIMS 2016 MRI criteria. CONCLUSIONS: MAGNIMS 2016 MRI criteria were superior to McDonald 2010 MRI criteria in specificity, accuracy, and PPV, but inferior in sensitivity and NPV. SN - 1738-6586 UR - https://www.unboundmedicine.com/medline/citation/29856160/Applicability_of_McDonald_2010_and_Magnetic_Resonance_Imaging_in_Multiple_Sclerosis__MAGNIMS__2016_Magnetic_Resonance_Imaging_Criteria_for_the_Diagnosis_of_Multiple_Sclerosis_in_Sri_Lanka_ L2 - https://thejcn.com/DOIx.php?id=10.3988/jcn.2018.14.3.339 DB - PRIME DP - Unbound Medicine ER -