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Nocebo Effects and Scratching Behaviour on Itch.
Acta Derm Venereol. 2018 Nov 05; 98(10):943-950.AD

Abstract

Nocebo effects, i.e. reduced treatment effects due to patients' negative expectations, play a role in itch. Recent studies have shown that nocebo effects can be induced experimentally on itch and also be minimized and even turned into the opposite direction, i.e. placebo effects. It is not known whether these effects generalize to itch-associated scratching behaviour. The aim of this study was to determine whether induction and reversal of nocebo effects on itch evoked by electrical and histamine stimuli generalized to scratching. Ninety-seven healthy participants were included in the study. The manipulation was successful, as during the nocebo learning phase, increased scratching responses were found for higher intensity compared with lower intensity itch stimuli. During the testing phase of induction or reversal of the nocebo effects, however, no significant nocebo effects or reversed nocebo effects, were found in scratching. Thus, no straightforward generalization of nocebo effects from itch to scratching was found in this laboratory setting. Further investigation into possible generalization is needed in different settings and in patients with chronic itch.

Authors+Show Affiliations

Health Medical and Neuropsychology, Leiden University, NL-2300 RB Leiden, The Netherlands. d.bartels@fsw.leidenuniv.nl.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29856465

Citation

Bartels, Danielle J P., et al. "Nocebo Effects and Scratching Behaviour On Itch." Acta Dermato-venereologica, vol. 98, no. 10, 2018, pp. 943-950.
Bartels DJP, van Laarhoven AIM, van de Kerkhof PCM, et al. Nocebo Effects and Scratching Behaviour on Itch. Acta Derm Venereol. 2018;98(10):943-950.
Bartels, D. J. P., van Laarhoven, A. I. M., van de Kerkhof, P. C. M., & Evers, A. W. M. (2018). Nocebo Effects and Scratching Behaviour on Itch. Acta Dermato-venereologica, 98(10), 943-950. https://doi.org/10.2340/00015555-2979
Bartels DJP, et al. Nocebo Effects and Scratching Behaviour On Itch. Acta Derm Venereol. 2018 Nov 5;98(10):943-950. PubMed PMID: 29856465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocebo Effects and Scratching Behaviour on Itch. AU - Bartels,Danielle J P, AU - van Laarhoven,Antoinette I M, AU - van de Kerkhof,Peter C M, AU - Evers,Andrea W M, PY - 2018/6/2/pubmed PY - 2019/2/16/medline PY - 2018/6/2/entrez KW - conditioning KW - itch KW - nocebo KW - placebo KW - scratching KW - verbalsuggestion SP - 943 EP - 950 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 98 IS - 10 N2 - Nocebo effects, i.e. reduced treatment effects due to patients' negative expectations, play a role in itch. Recent studies have shown that nocebo effects can be induced experimentally on itch and also be minimized and even turned into the opposite direction, i.e. placebo effects. It is not known whether these effects generalize to itch-associated scratching behaviour. The aim of this study was to determine whether induction and reversal of nocebo effects on itch evoked by electrical and histamine stimuli generalized to scratching. Ninety-seven healthy participants were included in the study. The manipulation was successful, as during the nocebo learning phase, increased scratching responses were found for higher intensity compared with lower intensity itch stimuli. During the testing phase of induction or reversal of the nocebo effects, however, no significant nocebo effects or reversed nocebo effects, were found in scratching. Thus, no straightforward generalization of nocebo effects from itch to scratching was found in this laboratory setting. Further investigation into possible generalization is needed in different settings and in patients with chronic itch. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/29856465/Nocebo_Effects_and_Scratching_Behaviour_on_Itch_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2979 DB - PRIME DP - Unbound Medicine ER -