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Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases.
Int J Mol Sci. 2018 May 31; 19(6)IJ

Abstract

Progressive accumulation of misfolded amyloid proteins in intracellular and extracellular spaces is one of the principal reasons for synaptic damage and impairment of neuronal communication in several neurodegenerative diseases. Effective treatments for these diseases are still lacking but remain the focus of much active investigation. Despite testing several synthesized compounds, small molecules, and drugs over the past few decades, very few of them can inhibit aggregation of amyloid proteins and lessen their neurotoxic effects. Recently, the natural polyphenol curcumin (Cur) has been shown to be a promising anti-amyloid, anti-inflammatory and neuroprotective agent for several neurodegenerative diseases. Because of its pleotropic actions on the central nervous system, including preferential binding to amyloid proteins, Cur is being touted as a promising treatment for age-related brain diseases. Here, we focus on molecular targeting of Cur to reduce amyloid burden, rescue neuronal damage, and restore normal cognitive and sensory motor functions in different animal models of neurodegenerative diseases. We specifically highlight Cur as a potential treatment for Alzheimer's, Parkinson's, Huntington's, and prion diseases. In addition, we discuss the major issues and limitations of using Cur for treating these diseases, along with ways of circumventing those shortcomings. Finally, we provide specific recommendations for optimal dosing with Cur for treating neurological diseases.

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Authors+Show Affiliations

Maiti P
Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA. maiti1p@cmich.edu. Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA. maiti1p@cmich.edu. Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USA. maiti1p@cmich.edu. Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI 48604, USA. maiti1p@cmich.edu. Department of Biology, Saginaw Valley State University, Saginaw, MI 48610, USA. maiti1p@cmich.edu. Brain Research Laboratory, Saginaw Valley State University, Saginaw, MI 48610, USA. maiti1p@cmich.edu.
Dunbar GL
Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA. dunba1g@cmich.edu. Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA. dunba1g@cmich.edu. Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USA. dunba1g@cmich.edu. Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI 48604, USA. dunba1g@cmich.edu.

MeSH

Age FactorsAgingAmyloidAmyloidosisAnimalsAnti-Inflammatory AgentsBiological ProductsCurcuminDose-Response Relationship, DrugDrug Delivery SystemsHumansNanomedicineNanotechnologyNerve TissueNeurodegenerative DiseasesNeuroprotective AgentsPolyphenolsSignal Transduction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29857538

Citation

Maiti, Panchanan, and Gary Leo Dunbar. "Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 19, no. 6, 2018.
Maiti P, Dunbar GL. Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases. Int J Mol Sci. 2018;19(6).
Maiti, P., & Dunbar, G. L. (2018). Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases. International Journal of Molecular Sciences, 19(6). https://doi.org/10.3390/ijms19061637
Maiti P, Dunbar GL. Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases. Int J Mol Sci. 2018 May 31;19(6) PubMed PMID: 29857538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases. AU - Maiti,Panchanan, AU - Dunbar,Gary Leo, Y1 - 2018/05/31/ PY - 2018/03/31/received PY - 2018/05/02/revised PY - 2018/05/25/accepted PY - 2018/6/3/entrez PY - 2018/6/3/pubmed PY - 2018/10/3/medline KW - amyloidosis KW - anti-amyloid KW - curcumin KW - molecular chaperones KW - natural polyphenol KW - neurodegenerative diseases KW - neuroinflammation JF - International journal of molecular sciences JO - Int J Mol Sci VL - 19 IS - 6 N2 - Progressive accumulation of misfolded amyloid proteins in intracellular and extracellular spaces is one of the principal reasons for synaptic damage and impairment of neuronal communication in several neurodegenerative diseases. Effective treatments for these diseases are still lacking but remain the focus of much active investigation. Despite testing several synthesized compounds, small molecules, and drugs over the past few decades, very few of them can inhibit aggregation of amyloid proteins and lessen their neurotoxic effects. Recently, the natural polyphenol curcumin (Cur) has been shown to be a promising anti-amyloid, anti-inflammatory and neuroprotective agent for several neurodegenerative diseases. Because of its pleotropic actions on the central nervous system, including preferential binding to amyloid proteins, Cur is being touted as a promising treatment for age-related brain diseases. Here, we focus on molecular targeting of Cur to reduce amyloid burden, rescue neuronal damage, and restore normal cognitive and sensory motor functions in different animal models of neurodegenerative diseases. We specifically highlight Cur as a potential treatment for Alzheimer's, Parkinson's, Huntington's, and prion diseases. In addition, we discuss the major issues and limitations of using Cur for treating these diseases, along with ways of circumventing those shortcomings. Finally, we provide specific recommendations for optimal dosing with Cur for treating neurological diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/29857538/Use_of_Curcumin_a_Natural_Polyphenol_for_Targeting_Molecular_Pathways_in_Treating_Age_Related_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -