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Macular dysfunction in patients with macula-on rhegmatogenous retinal detachments.
Br J Ophthalmol. 2019 03; 103(3):404-409.BJ

Abstract

AIMS

To assess macular function in patients with macula-on rhegmatogenous retinal detachments (RRDs) using focal macular electroretinography (FMERG).

METHODS

This is a prospective, observational case series of 27 patients diagnosed with a macula-on RRD. Foveal attachment was confirmed on spectral-domain optical coherence tomography. Eyes with any macular disorder, cataract, vitreous opacity or vitreous haemorrhage were excluded. FMERG was recorded in the affected and fellow eyes using a round stimulus 15° in diameter. The status of four retinal factors in the affected eyes was examined, that is, the number of involved quadrants, number of quadrants with retinal breaks, presence of an RRD invading the vascular arcade, and presence of a giant retinal tear. The implicit time and amplitude of the a-wave, b-wave and oscillatory potentials (OPs) were compared between the affected and fellow eyes using Wilcoxon signed-rank test. The influence of the four retinal factors on each FMERG component of the affected eyes was also evaluated using Mann-Whitney U test and Kruskal-Wallis test.

RESULTS

Significant reductions in the amplitudes of the a-waves (p=0.001), b-waves (p<0.001) and OPs (p=0.001) were observed in the affected eyes compared with the fellow eyes. There was no significant difference between the affected and fellow eyes in the implicit times of any components. None of the four retinal factors affected the parameters in the affected eyes.

CONCLUSION

Altered FMERG responses suggested the presence of macular dysfunction in eyes with macula-on RRDs.

Authors+Show Affiliations

Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan kakiyama@ntmc-hosp.jp. Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan. Genetics, UCL Institute of Ophthalmology, London, UK.Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Aichi Medical University, Aichi, Japan.Department of Ophthalmology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan. Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29858185

Citation

Akiyama, Kunihiko, et al. "Macular Dysfunction in Patients With Macula-on Rhegmatogenous Retinal Detachments." The British Journal of Ophthalmology, vol. 103, no. 3, 2019, pp. 404-409.
Akiyama K, Fujinami K, Watanabe K, et al. Macular dysfunction in patients with macula-on rhegmatogenous retinal detachments. Br J Ophthalmol. 2019;103(3):404-409.
Akiyama, K., Fujinami, K., Watanabe, K., Noda, T., Miyake, Y., & Tsunoda, K. (2019). Macular dysfunction in patients with macula-on rhegmatogenous retinal detachments. The British Journal of Ophthalmology, 103(3), 404-409. https://doi.org/10.1136/bjophthalmol-2018-312153
Akiyama K, et al. Macular Dysfunction in Patients With Macula-on Rhegmatogenous Retinal Detachments. Br J Ophthalmol. 2019;103(3):404-409. PubMed PMID: 29858185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular dysfunction in patients with macula-on rhegmatogenous retinal detachments. AU - Akiyama,Kunihiko, AU - Fujinami,Kaoru, AU - Watanabe,Ken, AU - Noda,Toru, AU - Miyake,Yozo, AU - Tsunoda,Kazushige, Y1 - 2018/06/01/ PY - 2018/02/26/received PY - 2018/04/24/revised PY - 2018/04/29/accepted PY - 2018/6/3/pubmed PY - 2019/10/28/medline PY - 2018/6/3/entrez KW - electroretinogram KW - focal macular electroretinogram. KW - macula-on KW - macular function KW - rhegmatogenous retinal detachment SP - 404 EP - 409 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 103 IS - 3 N2 - AIMS: To assess macular function in patients with macula-on rhegmatogenous retinal detachments (RRDs) using focal macular electroretinography (FMERG). METHODS: This is a prospective, observational case series of 27 patients diagnosed with a macula-on RRD. Foveal attachment was confirmed on spectral-domain optical coherence tomography. Eyes with any macular disorder, cataract, vitreous opacity or vitreous haemorrhage were excluded. FMERG was recorded in the affected and fellow eyes using a round stimulus 15° in diameter. The status of four retinal factors in the affected eyes was examined, that is, the number of involved quadrants, number of quadrants with retinal breaks, presence of an RRD invading the vascular arcade, and presence of a giant retinal tear. The implicit time and amplitude of the a-wave, b-wave and oscillatory potentials (OPs) were compared between the affected and fellow eyes using Wilcoxon signed-rank test. The influence of the four retinal factors on each FMERG component of the affected eyes was also evaluated using Mann-Whitney U test and Kruskal-Wallis test. RESULTS: Significant reductions in the amplitudes of the a-waves (p=0.001), b-waves (p<0.001) and OPs (p=0.001) were observed in the affected eyes compared with the fellow eyes. There was no significant difference between the affected and fellow eyes in the implicit times of any components. None of the four retinal factors affected the parameters in the affected eyes. CONCLUSION: Altered FMERG responses suggested the presence of macular dysfunction in eyes with macula-on RRDs. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/29858185/Macular_dysfunction_in_patients_with_macula_on_rhegmatogenous_retinal_detachments_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=29858185 DB - PRIME DP - Unbound Medicine ER -