Tags

Type your tag names separated by a space and hit enter

Association between depression and the subsequent risk of Parkinson's disease: A meta-analysis.

Abstract

BACKGROUND

Observational studies, including recent large cohort studies, have reported an association between depression and the risk of Parkinson's disease (PD); however, conclusions were inconsistent. Clarifying this relation might improve the understanding of risk factors for and the disease mechanisms in PD. Therefore, we performed a meta-analysis to examine whether depression is associated with an increased risk of PD.

METHODS

A literature search in the PubMed, EMBASE, Scopus, PsycINFO and Web of Science databases was undertaken through March 2018, looking for observational studies evaluating the association between depression and the risk of PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup analyses and sensitivity analyses were also performed.

RESULTS

A random-effects meta-analysis of 5 cohort studies and 6 case-control studies demonstrated a significant positive association between depression and a subsequent risk of PD (RR, 2.20; 95% CI, 1.87-2.58), and it was consistent across subgroups. Furthermore, sensitivity analysis confirmed the stability of the results; visual examination of funnel plots and Begg's and Egger's tests showed no evidence of publication bias.

CONCLUSIONS

Our meta-analysis demonstrated that persons with depression exhibited an increased risk of a subsequent PD diagnosis. The pathophysiological and psychological mechanisms underlying this association are still unclear and warrant further research.

Authors+Show Affiliations

Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China. Electronic address: maoshanp@whu.edu.cn.Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

29859854

Citation

Wang, Shun, et al. "Association Between Depression and the Subsequent Risk of Parkinson's Disease: a Meta-analysis." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 86, 2018, pp. 186-192.
Wang S, Mao S, Xiang D, et al. Association between depression and the subsequent risk of Parkinson's disease: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:186-192.
Wang, S., Mao, S., Xiang, D., & Fang, C. (2018). Association between depression and the subsequent risk of Parkinson's disease: A meta-analysis. Progress in Neuro-psychopharmacology & Biological Psychiatry, 86, 186-192. https://doi.org/10.1016/j.pnpbp.2018.05.025
Wang S, et al. Association Between Depression and the Subsequent Risk of Parkinson's Disease: a Meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2018 08 30;86:186-192. PubMed PMID: 29859854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between depression and the subsequent risk of Parkinson's disease: A meta-analysis. AU - Wang,Shun, AU - Mao,Shanping, AU - Xiang,Dan, AU - Fang,Congcong, Y1 - 2018/05/31/ PY - 2017/12/15/received PY - 2018/05/30/revised PY - 2018/05/30/accepted PY - 2018/6/4/pubmed PY - 2019/4/16/medline PY - 2018/6/4/entrez SP - 186 EP - 192 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 86 N2 - BACKGROUND: Observational studies, including recent large cohort studies, have reported an association between depression and the risk of Parkinson's disease (PD); however, conclusions were inconsistent. Clarifying this relation might improve the understanding of risk factors for and the disease mechanisms in PD. Therefore, we performed a meta-analysis to examine whether depression is associated with an increased risk of PD. METHODS: A literature search in the PubMed, EMBASE, Scopus, PsycINFO and Web of Science databases was undertaken through March 2018, looking for observational studies evaluating the association between depression and the risk of PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup analyses and sensitivity analyses were also performed. RESULTS: A random-effects meta-analysis of 5 cohort studies and 6 case-control studies demonstrated a significant positive association between depression and a subsequent risk of PD (RR, 2.20; 95% CI, 1.87-2.58), and it was consistent across subgroups. Furthermore, sensitivity analysis confirmed the stability of the results; visual examination of funnel plots and Begg's and Egger's tests showed no evidence of publication bias. CONCLUSIONS: Our meta-analysis demonstrated that persons with depression exhibited an increased risk of a subsequent PD diagnosis. The pathophysiological and psychological mechanisms underlying this association are still unclear and warrant further research. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/29859854/Association_between_depression_and_the_subsequent_risk_of_Parkinson's_disease:_A_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(17)31008-4 DB - PRIME DP - Unbound Medicine ER -