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Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic.
Biomed Pharmacother. 2018 Jul; 103:1464-1472.BP

Abstract

Chronic exposure to arsenic, an inducer of oxidative stress, is one of the major causes of male infertility. Therefore, the present study investigated the protective role of Ellagic acid (EA), as a natural antioxidant, against testicular toxicity evoked by arsenic. Thirty-five male Wistar rats were divided into 5 treatment groups. Group 1 served as control, group 2 were orally exposed to sodium arsenite (SA, 10 mg/kg; 21 days), groups 3 and 4 were initially exposed to SA for 7 days and then were treated with both EA (10 and 30 mg/kg) and SA up to 21 days, and group 5 was treated with EA for 14 days. After this period, biochemical and histopathological parameters were evaluated in serum samples and testicular tissue. SA markedly reduced levels of serum testosterone, total antioxidant capacity, reduced glutathione as well as the activity of antioxidant enzymes. Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-α, interleukin-1β and nitric oxide in testes. Treatment with EA was found to reduce testicular arsenic accumulation and oxidative stress parameters. In addition, EA improved the serum testosterone level, testicular antioxidant markers and histological parameters after exposure to SA. EA may emerge as a promising therapeutic option to protect testes from arsenic-induced toxicity through reducing oxidative stress and inflammatory responses.

Authors+Show Affiliations

Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.Department of Midwifery, Faculty of Nursing and Midwifery, Dezful University of Medical Sciences, Dezful, Iran.Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: Mehrzadi.s@iums.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29864931

Citation

Mehrzadi, Saeed, et al. "Ellagic Acid: a Promising Protective Remedy Against Testicular Toxicity Induced By Arsenic." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 103, 2018, pp. 1464-1472.
Mehrzadi S, Bahrami N, Mehrabani M, et al. Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic. Biomed Pharmacother. 2018;103:1464-1472.
Mehrzadi, S., Bahrami, N., Mehrabani, M., Motevalian, M., Mansouri, E., & Goudarzi, M. (2018). Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 103, 1464-1472. https://doi.org/10.1016/j.biopha.2018.04.194
Mehrzadi S, et al. Ellagic Acid: a Promising Protective Remedy Against Testicular Toxicity Induced By Arsenic. Biomed Pharmacother. 2018;103:1464-1472. PubMed PMID: 29864931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic. AU - Mehrzadi,Saeed, AU - Bahrami,Nosrat, AU - Mehrabani,Mehrnaz, AU - Motevalian,Manijeh, AU - Mansouri,Esrafil, AU - Goudarzi,Mehdi, Y1 - 2018/05/07/ PY - 2018/03/18/received PY - 2018/04/28/revised PY - 2018/04/29/accepted PY - 2018/6/6/entrez PY - 2018/6/6/pubmed PY - 2018/10/12/medline KW - Arsenic KW - Ellagic acid KW - Male infertility KW - Oxidative stress KW - Rat KW - Testes SP - 1464 EP - 1472 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 103 N2 - Chronic exposure to arsenic, an inducer of oxidative stress, is one of the major causes of male infertility. Therefore, the present study investigated the protective role of Ellagic acid (EA), as a natural antioxidant, against testicular toxicity evoked by arsenic. Thirty-five male Wistar rats were divided into 5 treatment groups. Group 1 served as control, group 2 were orally exposed to sodium arsenite (SA, 10 mg/kg; 21 days), groups 3 and 4 were initially exposed to SA for 7 days and then were treated with both EA (10 and 30 mg/kg) and SA up to 21 days, and group 5 was treated with EA for 14 days. After this period, biochemical and histopathological parameters were evaluated in serum samples and testicular tissue. SA markedly reduced levels of serum testosterone, total antioxidant capacity, reduced glutathione as well as the activity of antioxidant enzymes. Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-α, interleukin-1β and nitric oxide in testes. Treatment with EA was found to reduce testicular arsenic accumulation and oxidative stress parameters. In addition, EA improved the serum testosterone level, testicular antioxidant markers and histological parameters after exposure to SA. EA may emerge as a promising therapeutic option to protect testes from arsenic-induced toxicity through reducing oxidative stress and inflammatory responses. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/29864931/Ellagic_acid:_A_promising_protective_remedy_against_testicular_toxicity_induced_by_arsenic_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(18)31810-9 DB - PRIME DP - Unbound Medicine ER -