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Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients.
Nutrients. 2018 Jun 01; 10(6)N

Abstract

In patients suffering from chronic kidney disease (CKD), the prevalence of cardiovascular disease is much more common than in the general population. The role of vitamin D deficiency had been underestimated until a significant association was found between vitamin D therapy and survival benefit in haemodialysis patients. Vitamin D deficiency is present even in the early stages of chronic kidney disease. The results of experimental studies have revealed the relationship between vitamin D deficiency and impairment of cardiac contractile function, higher cardiac mass and increased myocardial collagen content. Experimental models propose that intermediate end points for the relationship between vitamin D deficiency and higher risk of cardiovascular disease comprise diminished left ventricular hypertrophy (LVH), enhanced left ventricular diastolic function, and decreased frequency of heart failure. Multiple observational studies have demonstrated an association between the use of active vitamin D therapy in patients on dialysis and with CKD and improved survival. However, there are also many studies indicating important adverse effects of such treatment. Therefore, large randomized trials are required to analyze whether supplementation of vitamin D may affect outcomes and whether it is safe to be used in CKD patients.

Authors+Show Affiliations

Department of Nephrology, Hypertension and Family Medicine, WAM Teaching Hospital, 90-549 Lodz, Poland. aniagluba@yahoo.pl.Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, Poland. bfranczyk-skora@wp.pl.Palliative Care Ward, Department of Oncology, Medical University of Lodz, 90-549 Lodz, Poland. olarysz@rmed.pl.Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences (IPPT PAN), 02-106 Warsaw, Poland. robert.olszewski@me.com.Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, Poland. jacek.rysz@umed.lodz.pl.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29865146

Citation

Gluba-Brzózka, Anna, et al. "Impact of Vitamin D On the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients." Nutrients, vol. 10, no. 6, 2018.
Gluba-Brzózka A, Franczyk B, Ciałkowska-Rysz A, et al. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(6).
Gluba-Brzózka, A., Franczyk, B., Ciałkowska-Rysz, A., Olszewski, R., & Rysz, J. (2018). Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients, 10(6). https://doi.org/10.3390/nu10060709
Gluba-Brzózka A, et al. Impact of Vitamin D On the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018 Jun 1;10(6) PubMed PMID: 29865146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. AU - Gluba-Brzózka,Anna, AU - Franczyk,Beata, AU - Ciałkowska-Rysz,Aleksandra, AU - Olszewski,Robert, AU - Rysz,Jacek, Y1 - 2018/06/01/ PY - 2018/05/02/received PY - 2018/05/24/revised PY - 2018/05/29/accepted PY - 2018/6/6/entrez PY - 2018/6/6/pubmed PY - 2018/10/30/medline KW - cardiovascular disease KW - chronic kidney disease KW - mortality KW - treatment KW - vitamin D KW - vitamin D analogues JF - Nutrients JO - Nutrients VL - 10 IS - 6 N2 - In patients suffering from chronic kidney disease (CKD), the prevalence of cardiovascular disease is much more common than in the general population. The role of vitamin D deficiency had been underestimated until a significant association was found between vitamin D therapy and survival benefit in haemodialysis patients. Vitamin D deficiency is present even in the early stages of chronic kidney disease. The results of experimental studies have revealed the relationship between vitamin D deficiency and impairment of cardiac contractile function, higher cardiac mass and increased myocardial collagen content. Experimental models propose that intermediate end points for the relationship between vitamin D deficiency and higher risk of cardiovascular disease comprise diminished left ventricular hypertrophy (LVH), enhanced left ventricular diastolic function, and decreased frequency of heart failure. Multiple observational studies have demonstrated an association between the use of active vitamin D therapy in patients on dialysis and with CKD and improved survival. However, there are also many studies indicating important adverse effects of such treatment. Therefore, large randomized trials are required to analyze whether supplementation of vitamin D may affect outcomes and whether it is safe to be used in CKD patients. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29865146/Impact_of_Vitamin_D_on_the_Cardiovascular_System_in_Advanced_Chronic_Kidney_Disease__CKD__and_Dialysis_Patients_ L2 - https://www.mdpi.com/resolver?pii=nu10060709 DB - PRIME DP - Unbound Medicine ER -