TY - JOUR T1 - Twin Screw Granulation: Effects of Properties of Primary Powders. AU - Lute,Sushma V, AU - Dhenge,Ranjit M, AU - Salman,Agba D, Y1 - 2018/06/02/ PY - 2018/04/23/received PY - 2018/05/28/revised PY - 2018/05/30/accepted PY - 2018/6/6/entrez PY - 2018/6/6/pubmed PY - 2018/6/6/medline KW - continuous KW - excipient KW - granule KW - lactose KW - mannitol KW - tableting KW - twin screw wet granulation JF - Pharmaceutics JO - Pharmaceutics VL - 10 IS - 2 N2 - Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders separately. However, the comparison of the performance of these two types of powders during twin screw wet granulation has received no attention. The present research is focused on understanding the granulation mechanism of different grades of two pharmaceutical powders with varying properties (i.e., primary particle size, structure, and compressibility). Three grades each of lactose and mannitol were granulated at varying liquid to solid ratios (L/S) and screw speed. It was noticed that primary powder morphology plays an important role in determining the granule size and structure, and tablet tensile strength. It was indicated that the processed powders such as spray-dried and granulated lactose and mannitol can be used in formulation for wet granulation where flowability of active pharmaceutical ingredient (API) is poor. SN - 1999-4923 UR - https://www.unboundmedicine.com/medline/citation/29865249/Twin_Screw_Granulation:_Effects_of_Properties_of_Primary_Powders_ DB - PRIME DP - Unbound Medicine ER -