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Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients.
Balkan J Med Genet 2017; 20(2):67-74BJ

Abstract

Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A/C and SOD2 A16V (C/T) polymorphism allele frequencies were compared by using χ2 tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C/T) polymorphism, a significant difference was determined for the distribution of the genotypes [p = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients.

Authors+Show Affiliations

Department of Dermatology and Venerology, Faculty of Medicine, Ege University, Izmir, Turkey.Department of Dermatology and Venerology, Faculty of Medicine, Ege University, Izmir, Turkey.Department of Dermatology and Venerology, Faculty of Medicine, Ege University, Izmir, Turkey.Department of Genetics, Faculty of Medicine, Ege University, Izmir, Turkey.Department of Genetics, Faculty of Medicine, Ege University, Izmir, Turkey.Department of Genetics, Faculty of Medicine, Ege University, Izmir, Turkey.Department of Genetics, Faculty of Medicine, Ege University, Izmir, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29876235

Citation

A, Tuna, et al. "Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients." Balkan Journal of Medical Genetics : BJMG, vol. 20, no. 2, 2017, pp. 67-74.
A T, G O, Tb G, et al. Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients. Balkan J Med Genet. 2017;20(2):67-74.
A, T., G, O., Tb, G., E, K., H, O., Sm, G., & O, C. (2017). Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients. Balkan Journal of Medical Genetics : BJMG, 20(2), pp. 67-74. doi:10.1515/bjmg-2017-0033.
A T, et al. Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients. Balkan J Med Genet. 2017;20(2):67-74. PubMed PMID: 29876235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients. AU - A,Tuna, AU - G,Ozturk, AU - Tb,Gerceker, AU - E,Karaca,M.D., Associacte Professor AU - H,Onay, AU - Sm,Guvenc, AU - O,Cogulu, Y1 - 2017/12/29/ PY - 2018/6/8/entrez PY - 2018/6/8/pubmed PY - 2018/6/8/medline KW - SOD1 KW - SOD2 KW - Superoxide dismutase (SOD) KW - Vitiligo SP - 67 EP - 74 JF - Balkan journal of medical genetics : BJMG JO - Balkan J. Med. Genet. VL - 20 IS - 2 N2 - Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A/C and SOD2 A16V (C/T) polymorphism allele frequencies were compared by using χ2 tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C/T) polymorphism, a significant difference was determined for the distribution of the genotypes [p = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients. SN - 1311-0160 UR - https://www.unboundmedicine.com/medline/citation/29876235/Superoxide_Dismutase_1_and_2_Gene_Polymorphism_in_Turkish_Vitiligo_Patients L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29876235/ DB - PRIME DP - Unbound Medicine ER -