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Sulfonamide Drug Allergy.
Curr Allergy Asthma Rep 2018; 18(7):38CA

Abstract

PURPOSE OF REVIEW

We sought to review past and current literature on sulfonamide drug allergy and distill it in a practical manner to assist the clinician, specifically focusing on cross-reactivity and desensitization.

RECENT FINDINGS

There do not appear to be consistent genetic markers to reliably predict features of or the presence hypersensitivity reactions. Recent evidence continues to alleviate early concerns cross-reactivity between sulfonamide antibiotics and non-antibiotics. Sulfonamide drug allergy is frequently encountered by the practicing clinician. For sulfonamide antibiotics, delayed rash is the most common clinical manifestation. There is no current evidence to support avoidance of all non-antibiotic sulfonamides in those with a reported allergy to sulfonamide antibiotics, although certain scenarios require caution. Available evidence supports the cautious reintroduction of sulfonamide antibiotics via desensitization, which is usually well tolerated and should be considered in those with strong indications for trimethoprim-sulfamethoxazole and a reported sulfonamide allergy.

Authors+Show Affiliations

Mayo Clinic, Division of Allergic Diseases, 200 First Street SW, Rochester, MN, 55905, USA.Mayo Clinic, Division of Allergic Diseases, 200 First Street SW, Rochester, MN, 55905, USA.Mayo Clinic, Division of Allergic Diseases, 200 First Street SW, Rochester, MN, 55905, USA.Mayo Clinic, Division of Allergic Diseases, 200 First Street SW, Rochester, MN, 55905, USA. Volcheck.gerald@mayo.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29876667

Citation

Dorn, Joshua M., et al. "Sulfonamide Drug Allergy." Current Allergy and Asthma Reports, vol. 18, no. 7, 2018, p. 38.
Dorn JM, Alpern M, McNulty C, et al. Sulfonamide Drug Allergy. Curr Allergy Asthma Rep. 2018;18(7):38.
Dorn, J. M., Alpern, M., McNulty, C., & Volcheck, G. W. (2018). Sulfonamide Drug Allergy. Current Allergy and Asthma Reports, 18(7), p. 38. doi:10.1007/s11882-018-0791-9.
Dorn JM, et al. Sulfonamide Drug Allergy. Curr Allergy Asthma Rep. 2018 06 6;18(7):38. PubMed PMID: 29876667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfonamide Drug Allergy. AU - Dorn,Joshua M, AU - Alpern,Mollie, AU - McNulty,Caitlin, AU - Volcheck,Gerald W, Y1 - 2018/06/06/ PY - 2018/6/8/entrez PY - 2018/6/8/pubmed PY - 2019/5/18/medline KW - Cross-reactivity KW - Cross-sensitivity KW - Drug allergy KW - Hypersensitivity KW - Sulfonamide SP - 38 EP - 38 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 18 IS - 7 N2 - PURPOSE OF REVIEW: We sought to review past and current literature on sulfonamide drug allergy and distill it in a practical manner to assist the clinician, specifically focusing on cross-reactivity and desensitization. RECENT FINDINGS: There do not appear to be consistent genetic markers to reliably predict features of or the presence hypersensitivity reactions. Recent evidence continues to alleviate early concerns cross-reactivity between sulfonamide antibiotics and non-antibiotics. Sulfonamide drug allergy is frequently encountered by the practicing clinician. For sulfonamide antibiotics, delayed rash is the most common clinical manifestation. There is no current evidence to support avoidance of all non-antibiotic sulfonamides in those with a reported allergy to sulfonamide antibiotics, although certain scenarios require caution. Available evidence supports the cautious reintroduction of sulfonamide antibiotics via desensitization, which is usually well tolerated and should be considered in those with strong indications for trimethoprim-sulfamethoxazole and a reported sulfonamide allergy. SN - 1534-6315 UR - https://www.unboundmedicine.com/medline/citation/29876667/Sulfonamide_Drug_Allergy_ L2 - https://dx.doi.org/10.1007/s11882-018-0791-9 DB - PRIME DP - Unbound Medicine ER -