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24-h urine metabolic profile: is it necessary in all kidney stone formers?
Int Urol Nephrol 2018; 50(7):1243-1247IU

Abstract

PURPOSE

A 24-h urine metabolic profile (24-UMP) is an integral part of nephrolithiasis work-up. We aimed to explore whether it can be waived under certain circumstances.

MATERIALS AND METHODS

We reviewed our prospective registry database of patients seen at our outpatient clinic for nephrolithiasis between the years 2010 and 2017. Data included: gender, age at first stone, body mass index (BMI), self-reported comorbidities and family history of nephrolithiasis. A 24-UMP was obtained from each patient under random diet. The following were recorded: urine volume, urinary levels of sodium, calcium, uric acid, oxalate and citrate. Presence of at least one comorbidity (i.e., hypertension/diabetes/hyperlipidemia) was defined as "associated comorbidities" (AC). Their absence was defined as "no comorbidities" (NC). Subjects were divided into two subgroups: first-time and recurrent stone formers, which were further divided into two subgroups: 1st + AC; 1st + NC; recurrent + AC; recurrent + NC. 24-UMPs have been compared between the four groups.

RESULTS

Four hundred and fifty-seven patients were included in the study. In the AC groups, patients demonstrated higher BMI levels (p = 0.001), and were statistically significantly obese (BMI > 30, p = 0.001) and older at first stone event (p = 0.001). First formers, either with AC or NC were more likely to have low urine volume (LUV) compared with recurrent formers (72.5 vs. 59.5%, p = 0.005). In the remaining metabolic abnormalities, no such differences were observed.

CONCLUSIONS

First-time stone formers, either with or without AC are likely to demonstrate LUV as their primary metabolic abnormality in 24-UMP. Therefore, 24-UMP may be postponed until recurrent stone event.

Authors+Show Affiliations

Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel. ag.yasmin@gmail.com. Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. ag.yasmin@gmail.com.Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel. Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel. Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel. Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel. Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29876775

Citation

Abu-Ghanem, Yasmin, et al. "24-h Urine Metabolic Profile: Is It Necessary in All Kidney Stone Formers?" International Urology and Nephrology, vol. 50, no. 7, 2018, pp. 1243-1247.
Abu-Ghanem Y, Shvero A, Kleinmann N, et al. 24-h urine metabolic profile: is it necessary in all kidney stone formers? Int Urol Nephrol. 2018;50(7):1243-1247.
Abu-Ghanem, Y., Shvero, A., Kleinmann, N., Winkler, H. Z., & Zilberman, D. E. (2018). 24-h urine metabolic profile: is it necessary in all kidney stone formers? International Urology and Nephrology, 50(7), pp. 1243-1247. doi:10.1007/s11255-018-1902-1.
Abu-Ghanem Y, et al. 24-h Urine Metabolic Profile: Is It Necessary in All Kidney Stone Formers. Int Urol Nephrol. 2018;50(7):1243-1247. PubMed PMID: 29876775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 24-h urine metabolic profile: is it necessary in all kidney stone formers? AU - Abu-Ghanem,Yasmin, AU - Shvero,Asaf, AU - Kleinmann,Nir, AU - Winkler,Harry Z, AU - Zilberman,Dorit E, Y1 - 2018/06/06/ PY - 2018/03/24/received PY - 2018/05/23/accepted PY - 2018/6/8/pubmed PY - 2019/7/16/medline PY - 2018/6/8/entrez KW - 24-h urine metabolic profile KW - Comorbidities KW - Low urine volume KW - Nephrolithiasis KW - Stone recurrence SP - 1243 EP - 1247 JF - International urology and nephrology JO - Int Urol Nephrol VL - 50 IS - 7 N2 - PURPOSE: A 24-h urine metabolic profile (24-UMP) is an integral part of nephrolithiasis work-up. We aimed to explore whether it can be waived under certain circumstances. MATERIALS AND METHODS: We reviewed our prospective registry database of patients seen at our outpatient clinic for nephrolithiasis between the years 2010 and 2017. Data included: gender, age at first stone, body mass index (BMI), self-reported comorbidities and family history of nephrolithiasis. A 24-UMP was obtained from each patient under random diet. The following were recorded: urine volume, urinary levels of sodium, calcium, uric acid, oxalate and citrate. Presence of at least one comorbidity (i.e., hypertension/diabetes/hyperlipidemia) was defined as "associated comorbidities" (AC). Their absence was defined as "no comorbidities" (NC). Subjects were divided into two subgroups: first-time and recurrent stone formers, which were further divided into two subgroups: 1st + AC; 1st + NC; recurrent + AC; recurrent + NC. 24-UMPs have been compared between the four groups. RESULTS: Four hundred and fifty-seven patients were included in the study. In the AC groups, patients demonstrated higher BMI levels (p = 0.001), and were statistically significantly obese (BMI > 30, p = 0.001) and older at first stone event (p = 0.001). First formers, either with AC or NC were more likely to have low urine volume (LUV) compared with recurrent formers (72.5 vs. 59.5%, p = 0.005). In the remaining metabolic abnormalities, no such differences were observed. CONCLUSIONS: First-time stone formers, either with or without AC are likely to demonstrate LUV as their primary metabolic abnormality in 24-UMP. Therefore, 24-UMP may be postponed until recurrent stone event. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/29876775/24_h_urine_metabolic_profile:_is_it_necessary_in_all_kidney_stone_formers L2 - https://doi.org/10.1007/s11255-018-1902-1 DB - PRIME DP - Unbound Medicine ER -