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Optimization of the electrochemical degradation process of the antibiotic ciprofloxacin using a double-sided β-PbO2 anode in a flow reactor: kinetics, identification of oxidation intermediates and toxicity evaluation.
Environ Sci Pollut Res Int. 2019 Feb; 26(5):4438-4449.ES

Abstract

The electrochemical degradation of ciprofloxacin-CIP (50 mg L-1 in 0.10 mol L-1 Na2SO4) was investigated using a double-sided Ti-Pt/β-PbO2 anode in a filter-press flow reactor, with identification of oxidation intermediates and follow-up of antimicrobial activity against Escherichia coli. The effect of solution pH, flow rate, current density, and temperature on the CIP removal rate was evaluated. All of these parameters did affect the CIP removal performance; thus, optimized electrolysis conditions were further explored: pH = 10, qV = 6.5 L min-1, j = 30 mA cm-2, and θ = 25 °C. Therefore, CIP was removed within 2 h, whereas ~75% of the total organic carbon concentration (TOC) was removed after 5 h and then, the solution no longer presented antimicrobial activity. When the electrochemical degradation of CIP was investigated using a single-sided boron-doped diamond (BDD) anode, its performance in TOC removal was similar to that of the Ti-Pt/β-PbO2 anode; considering the higher oxidation power of BDD, the surprisingly good comparative performance of the Ti-Pt/β-PbO2 anode was ascribed to significantly better hydrodynamic conditions attained in the filter-press reactor used with this electrode. Five initial oxidation intermediates were identified by LC-MS/MS and completely removed after 4 h of electrolysis; since they have also been determined in other degradation processes, there must be similarities in the involved oxidation mechanisms. Five terminal oxidation intermediates (acetic, formic, oxamic, propionic, and succinic acids) were identified by LC-UV and all of them (except acetic acid) were removed after 10 h of electrolysis.

Authors+Show Affiliations

Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil.Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil.Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil.Instituto de Química de São Carlos, Universidade de São Paulo, Avenida João Dagnone 1100, São Carlos, SP, 13563-120, Brazil.Departamento de Engenharia Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil.Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil.Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil. romeu@ufscar.br.Departamento de Química, Universidade Federal de São Carlos, C.P. 676, São Carlos, SP, 13560-970, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29876851

Citation

Wachter, Naihara, et al. "Optimization of the Electrochemical Degradation Process of the Antibiotic Ciprofloxacin Using a Double-sided β-PbO2 Anode in a Flow Reactor: Kinetics, Identification of Oxidation Intermediates and Toxicity Evaluation." Environmental Science and Pollution Research International, vol. 26, no. 5, 2019, pp. 4438-4449.
Wachter N, Aquino JM, Denadai M, et al. Optimization of the electrochemical degradation process of the antibiotic ciprofloxacin using a double-sided β-PbO2 anode in a flow reactor: kinetics, identification of oxidation intermediates and toxicity evaluation. Environ Sci Pollut Res Int. 2019;26(5):4438-4449.
Wachter, N., Aquino, J. M., Denadai, M., Barreiro, J. C., Silva, A. J., Cass, Q. B., Rocha-Filho, R. C., & Bocchi, N. (2019). Optimization of the electrochemical degradation process of the antibiotic ciprofloxacin using a double-sided β-PbO2 anode in a flow reactor: kinetics, identification of oxidation intermediates and toxicity evaluation. Environmental Science and Pollution Research International, 26(5), 4438-4449. https://doi.org/10.1007/s11356-018-2349-8
Wachter N, et al. Optimization of the Electrochemical Degradation Process of the Antibiotic Ciprofloxacin Using a Double-sided β-PbO2 Anode in a Flow Reactor: Kinetics, Identification of Oxidation Intermediates and Toxicity Evaluation. Environ Sci Pollut Res Int. 2019;26(5):4438-4449. PubMed PMID: 29876851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of the electrochemical degradation process of the antibiotic ciprofloxacin using a double-sided β-PbO2 anode in a flow reactor: kinetics, identification of oxidation intermediates and toxicity evaluation. AU - Wachter,Naihara, AU - Aquino,José M, AU - Denadai,Marina, AU - Barreiro,Juliana C, AU - Silva,Adilson J, AU - Cass,Quezia B, AU - Rocha-Filho,Romeu C, AU - Bocchi,Nerilso, Y1 - 2018/06/06/ PY - 2018/02/04/received PY - 2018/05/16/accepted PY - 2018/6/8/pubmed PY - 2019/4/20/medline PY - 2018/6/8/entrez KW - Antimicrobial activity KW - BDD anode KW - Electrooxidation KW - Filter-press reactor KW - Ti-Pt/β-PbO2 anode SP - 4438 EP - 4449 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 5 N2 - The electrochemical degradation of ciprofloxacin-CIP (50 mg L-1 in 0.10 mol L-1 Na2SO4) was investigated using a double-sided Ti-Pt/β-PbO2 anode in a filter-press flow reactor, with identification of oxidation intermediates and follow-up of antimicrobial activity against Escherichia coli. The effect of solution pH, flow rate, current density, and temperature on the CIP removal rate was evaluated. All of these parameters did affect the CIP removal performance; thus, optimized electrolysis conditions were further explored: pH = 10, qV = 6.5 L min-1, j = 30 mA cm-2, and θ = 25 °C. Therefore, CIP was removed within 2 h, whereas ~75% of the total organic carbon concentration (TOC) was removed after 5 h and then, the solution no longer presented antimicrobial activity. When the electrochemical degradation of CIP was investigated using a single-sided boron-doped diamond (BDD) anode, its performance in TOC removal was similar to that of the Ti-Pt/β-PbO2 anode; considering the higher oxidation power of BDD, the surprisingly good comparative performance of the Ti-Pt/β-PbO2 anode was ascribed to significantly better hydrodynamic conditions attained in the filter-press reactor used with this electrode. Five initial oxidation intermediates were identified by LC-MS/MS and completely removed after 4 h of electrolysis; since they have also been determined in other degradation processes, there must be similarities in the involved oxidation mechanisms. Five terminal oxidation intermediates (acetic, formic, oxamic, propionic, and succinic acids) were identified by LC-UV and all of them (except acetic acid) were removed after 10 h of electrolysis. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/29876851/Optimization_of_the_electrochemical_degradation_process_of_the_antibiotic_ciprofloxacin_using_a_double_sided_β_PbO2_anode_in_a_flow_reactor:_kinetics_identification_of_oxidation_intermediates_and_toxicity_evaluation_ L2 - https://dx.doi.org/10.1007/s11356-018-2349-8 DB - PRIME DP - Unbound Medicine ER -