Tags

Type your tag names separated by a space and hit enter

A systematic review and meta-analysis of the direct epidemiological and economic effects of seasonal influenza vaccination on healthcare workers.
PLoS One. 2018; 13(6):e0198685.Plos

Abstract

BACKGROUND

Influenza vaccination is a commonly used intervention to prevent influenza infection in healthcare workers (HCWs) and onward transmission to other staff and patients. We undertook a systematic review to synthesize the latest evidence of the direct epidemiological and economic effectiveness of seasonal influenza vaccination among HCW.

METHODS

We conducted a systematic search of MEDLINE/PubMed, Scopus, and Cochrane Central Register of Controlled Trials from 1980 through January 2018. All studies comparing vaccinated and non-vaccinated (i.e. placebo or non-intervention) groups of HCWs were included. Research articles that focused on only patient-related outcomes or monovalent A(H1N1)pdm09 vaccines were excluded. Two reviewers independently selected articles and extracted data. Pooled-analyses were conducted on morbidity outcomes including laboratory-confirmed influenza, influenza-like illnesses (ILI), and absenteeism. Economic studies were summarized for the characteristics of methods and findings.

RESULTS

Thirteen articles met eligibility criteria: three articles were randomized controlled studies and ten were cohort studies. Pooled results showed a significant effect on laboratory-confirmed influenza incidence but not ILI. While the overall incidence of absenteeism was not changed by vaccine, ILI absenteeism was significantly reduced. The duration of absenteeism was also shortened by vaccination. All published economic evaluations consistently found that the immunization of HCW was cost saving based on crude estimates of avoided absenteeism by vaccination. No studies, however, comprehensively evaluated both health outcomes and costs of vaccination programs to examine cost-effectiveness.

DISCUSSION

Our findings reinforced the influenza vaccine effects in reducing infection incidence and length of absenteeism. A better understanding of the incidence of absenteeism and comprehensive economic program evaluations are required to ensure the best possible management of ill HCWs and the investment in HCW immunization in increasingly constrained financial environments. These steps are fundamental to establish sustainability and cost-effectiveness of vaccination programs and underpin HCW immunization policy.

Links

PMC Free PDF

Authors+Show Affiliations

Imai C
Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia. Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Toizumi M
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Hall L
Epidemiology and Biostatistics Division, School of Public Health, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Lambert S
UQ Child Health Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Halton K
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Merollini K
Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Sunshine Coast, Queensland, Australia.

MeSH

AbsenteeismCost-Benefit AnalysisHealth PersonnelHumansIncidenceInfectious Disease Transmission, Patient-to-ProfessionalInfectious Disease Transmission, Professional-to-PatientInfluenza VaccinesInfluenza, HumanSeasonsVaccination

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

29879206

Citation

Imai, Chisato, et al. "A Systematic Review and Meta-analysis of the Direct Epidemiological and Economic Effects of Seasonal Influenza Vaccination On Healthcare Workers." PloS One, vol. 13, no. 6, 2018, pp. e0198685.
Imai C, Toizumi M, Hall L, et al. A systematic review and meta-analysis of the direct epidemiological and economic effects of seasonal influenza vaccination on healthcare workers. PLoS One. 2018;13(6):e0198685.
Imai, C., Toizumi, M., Hall, L., Lambert, S., Halton, K., & Merollini, K. (2018). A systematic review and meta-analysis of the direct epidemiological and economic effects of seasonal influenza vaccination on healthcare workers. PloS One, 13(6), e0198685. https://doi.org/10.1371/journal.pone.0198685
Imai C, et al. A Systematic Review and Meta-analysis of the Direct Epidemiological and Economic Effects of Seasonal Influenza Vaccination On Healthcare Workers. PLoS One. 2018;13(6):e0198685. PubMed PMID: 29879206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review and meta-analysis of the direct epidemiological and economic effects of seasonal influenza vaccination on healthcare workers. AU - Imai,Chisato, AU - Toizumi,Michiko, AU - Hall,Lisa, AU - Lambert,Stephen, AU - Halton,Kate, AU - Merollini,Katharina, Y1 - 2018/06/07/ PY - 2017/10/23/received PY - 2018/05/23/accepted PY - 2018/6/8/entrez PY - 2018/6/8/pubmed PY - 2019/1/12/medline SP - e0198685 EP - e0198685 JF - PloS one JO - PLoS One VL - 13 IS - 6 N2 - BACKGROUND: Influenza vaccination is a commonly used intervention to prevent influenza infection in healthcare workers (HCWs) and onward transmission to other staff and patients. We undertook a systematic review to synthesize the latest evidence of the direct epidemiological and economic effectiveness of seasonal influenza vaccination among HCW. METHODS: We conducted a systematic search of MEDLINE/PubMed, Scopus, and Cochrane Central Register of Controlled Trials from 1980 through January 2018. All studies comparing vaccinated and non-vaccinated (i.e. placebo or non-intervention) groups of HCWs were included. Research articles that focused on only patient-related outcomes or monovalent A(H1N1)pdm09 vaccines were excluded. Two reviewers independently selected articles and extracted data. Pooled-analyses were conducted on morbidity outcomes including laboratory-confirmed influenza, influenza-like illnesses (ILI), and absenteeism. Economic studies were summarized for the characteristics of methods and findings. RESULTS: Thirteen articles met eligibility criteria: three articles were randomized controlled studies and ten were cohort studies. Pooled results showed a significant effect on laboratory-confirmed influenza incidence but not ILI. While the overall incidence of absenteeism was not changed by vaccine, ILI absenteeism was significantly reduced. The duration of absenteeism was also shortened by vaccination. All published economic evaluations consistently found that the immunization of HCW was cost saving based on crude estimates of avoided absenteeism by vaccination. No studies, however, comprehensively evaluated both health outcomes and costs of vaccination programs to examine cost-effectiveness. DISCUSSION: Our findings reinforced the influenza vaccine effects in reducing infection incidence and length of absenteeism. A better understanding of the incidence of absenteeism and comprehensive economic program evaluations are required to ensure the best possible management of ill HCWs and the investment in HCW immunization in increasingly constrained financial environments. These steps are fundamental to establish sustainability and cost-effectiveness of vaccination programs and underpin HCW immunization policy. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/29879206/A_systematic_review_and_meta_analysis_of_the_direct_epidemiological_and_economic_effects_of_seasonal_influenza_vaccination_on_healthcare_workers_ DB - PRIME DP - Unbound Medicine ER -