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Progressive multifocal leukoencephalopathy. A case report with special reference to SV40 etiology.
Acta Pathol Jpn. 1985 Jan; 35(1):173-81.AP

Abstract

Clinical, light- and electron microscopic, and immunohistochemical findings of a 44-year-old woman with progressive multifocal leukoencephalopathy were presented. Autopsy revealed a wide distribution of the demyelinating lesion in the cerebrum, cerebellum, brain stem and spinal cord, and intranuclear inclusion bodies and papova-like virions in transmission electron microscopy in the nuclei of oligodendrocytes. SV40 antigen was immunohistochemically detected in these inclusion bodies. The widespread extension of the lesions seemed to correlate with the duration of the patient's illness. The prolongation of the clinical course in this case may be dependent upon the lack of serious underlying diseases except for a small nodule of thyroid carcinoma, SV40 infection rather than JC virus infection and/or improved care of that kind of patient.

Authors

Hayashi T
No affiliation info available
Sumiyoshi A
No affiliation info available
Tanaka M
No affiliation info available
Araki S
No affiliation info available
Minamishima Y
No affiliation info available

MeSH

AdenocarcinomaAdultAnimalsAstrocytesBrainFemaleHumansLeukoencephalopathy, Progressive MultifocalMicroscopy, ElectronOligodendrogliaSimian virus 40Thyroid NeoplasmsTumor Virus Infections

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2988268

Citation

Hayashi, T, et al. "Progressive Multifocal Leukoencephalopathy. a Case Report With Special Reference to SV40 Etiology." Acta Pathologica Japonica, vol. 35, no. 1, 1985, pp. 173-81.
Hayashi T, Sumiyoshi A, Tanaka M, et al. Progressive multifocal leukoencephalopathy. A case report with special reference to SV40 etiology. Acta Pathol Jpn. 1985;35(1):173-81.
Hayashi, T., Sumiyoshi, A., Tanaka, M., Araki, S., & Minamishima, Y. (1985). Progressive multifocal leukoencephalopathy. A case report with special reference to SV40 etiology. Acta Pathologica Japonica, 35(1), 173-81.
Hayashi T, et al. Progressive Multifocal Leukoencephalopathy. a Case Report With Special Reference to SV40 Etiology. Acta Pathol Jpn. 1985;35(1):173-81. PubMed PMID: 2988268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive multifocal leukoencephalopathy. A case report with special reference to SV40 etiology. AU - Hayashi,T, AU - Sumiyoshi,A, AU - Tanaka,M, AU - Araki,S, AU - Minamishima,Y, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 173 EP - 81 JF - Acta pathologica japonica JO - Acta Pathol Jpn VL - 35 IS - 1 N2 - Clinical, light- and electron microscopic, and immunohistochemical findings of a 44-year-old woman with progressive multifocal leukoencephalopathy were presented. Autopsy revealed a wide distribution of the demyelinating lesion in the cerebrum, cerebellum, brain stem and spinal cord, and intranuclear inclusion bodies and papova-like virions in transmission electron microscopy in the nuclei of oligodendrocytes. SV40 antigen was immunohistochemically detected in these inclusion bodies. The widespread extension of the lesions seemed to correlate with the duration of the patient's illness. The prolongation of the clinical course in this case may be dependent upon the lack of serious underlying diseases except for a small nodule of thyroid carcinoma, SV40 infection rather than JC virus infection and/or improved care of that kind of patient. SN - 0001-6632 UR - https://www.unboundmedicine.com/medline/citation/2988268/Progressive_multifocal_leukoencephalopathy__A_case_report_with_special_reference_to_SV40_etiology_ DB - PRIME DP - Unbound Medicine ER -