Citation
Mansournia, Mohammad Ali, et al. "The Effects of Vitamin D Supplementation On Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 50, no. 6, 2018, pp. 429-440.
Mansournia MA, Ostadmohammadi V, Doosti-Irani A, et al. The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018;50(6):429-440.
Mansournia, M. A., Ostadmohammadi, V., Doosti-Irani, A., Ghayour-Mobarhan, M., Ferns, G., Akbari, H., Ghaderi, A., Talari, H. R., & Asemi, Z. (2018). The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 50(6), 429-440. https://doi.org/10.1055/a-0630-1303
Mansournia MA, et al. The Effects of Vitamin D Supplementation On Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018;50(6):429-440. PubMed PMID: 29883970.
TY - JOUR
T1 - The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
AU - Mansournia,Mohammad Ali,
AU - Ostadmohammadi,Vahidreza,
AU - Doosti-Irani,Amin,
AU - Ghayour-Mobarhan,Majid,
AU - Ferns,Gordon,
AU - Akbari,Hossein,
AU - Ghaderi,Amir,
AU - Talari,Hamid Reza,
AU - Asemi,Zatollah,
Y1 - 2018/06/08/
PY - 2018/6/9/entrez
PY - 2018/6/9/pubmed
PY - 2018/10/9/medline
SP - 429
EP - 440
JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
JO - Horm Metab Res
VL - 50
IS - 6
N2 - In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Overall, 33 studies were included in the meta-analyses. Vitamin D supplementation were found to significantly reduce serum high-sensitivity C-reactive protein (hs-CRP) (WMD 0.27; 95% CI, - 0.35, - 0.20; p<0.001) and malondialdehyde (MDA) levels (WMD - 0.43, 95% CI - 0.62, - 0.25, p<0.001) in diabetic patients. In addition, vitamin D supplementation were found to increase markers of nitric oxide (NO) release (WMD 4.33, 95% CI 0.96, 7.70), total serum antioxidant capacity (TAC) (WMD 57.34, 95% CI 33.48, 81.20, p<0.001) and total glutathione (GSH) levels (WMD 82.59, 95% CI 44.37, 120.81, p<0.001). Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO, TAC and GSH levels.
SN - 1439-4286
UR - https://www.unboundmedicine.com/medline/citation/29883970/The_Effects_of_Vitamin_D_Supplementation_on_Biomarkers_of_Inflammation_and_Oxidative_Stress_in_Diabetic_Patients:_A_Systematic_Review_and_Meta_Analysis_of_Randomized_Controlled_Trials_
DB - PRIME
DP - Unbound Medicine
ER -
