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Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells.
Food Chem. 2018 Nov 01; 265:101-110.FC

Abstract

The following oligostilbenoids were isolated from extracts of Vitis vinifera L. Pinot Noir grape canes produced at a pilot-plant scale: (E)-ε-viniferin, (E)-resveratrol, (E)-piceatannol, ampelopsin A, vitisin B, pallidol, (E)-δ-viniferin, (E)-ω-viniferin, (E)-trans-cis-miyabenol C, isorhapontigenin, scirpusin A, and a new isomer named isoscirpusin A. The antioxidant capacity of the isolated stilbenoids was studied by three different assays, and their 50% inhibition concentration (IC50) against cancer cells was determined by MTT reduction assay. Besides (E)-resveratrol, stilbenoids have outstanding antioxidant capacity in the ORAC-FL assay. The strongest antiproliferative effect was observed for (E)-piceatannol and ampelopsin A against the bladder cancer cell line J82. (E)-Piceatannol has inhibitory effect on human lung cancer SK-MES-1 cells. Moreover, the whole extract has antiproliferative effect on all tested cell lines. In conclusion, beside (E)-resveratrol, grape cane extract contains oligostilbenoids with potential health benefits. This underexploited viticultural residue has the potential to produce valuable phytochemicals or ingredients in functional foods.

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Authors+Show Affiliations

Sáez V
Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, P.O. Box 160-C, Concepción, Chile.
Pastene E
Laboratorio de Farmacognosia, Facultad de Farmacia, Universidad de Concepción, P.O. Box 160-C, 4070386 Concepción, Chile.
Vergara C
Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, P.O. Box 160-C, Concepción, Chile.
Mardones C
Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, P.O. Box 160-C, Concepción, Chile.
Hermosín-Gutiérrez I
Instituto Regional de Investigación Científica Aplicada, Universidad de Castilla-La Mancha, Campus Universitario s/n 13071, Ciudad Real, Spain.
Gómez-Alonso S
Instituto Regional de Investigación Científica Aplicada, Universidad de Castilla-La Mancha, Campus Universitario s/n 13071, Ciudad Real, Spain.
Gómez MV
Instituto Regional de Investigación Científica Aplicada, Universidad de Castilla-La Mancha, Campus Universitario s/n 13071, Ciudad Real, Spain.
Theoduloz C
Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, 3460000 Talca, Chile.
Riquelme S
Unidad de Desarrollo Tecnológico (UDT), Universidad de Concepción, Coronel, Chile.
von Baer D
Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, P.O. Box 160-C, Concepción, Chile. Electronic address: dvonbaer@udec.cl.

MeSH

Antineoplastic AgentsAntioxidantsCell Line, TumorCytoprotectionHumansStilbenesVitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29884360

Citation

Sáez, Vania, et al. "Oligostilbenoids in Vitis Vinifera L. Pinot Noir Grape Cane Extract: Isolation, Characterization, in Vitro Antioxidant Capacity and Anti-proliferative Effect On Cancer Cells." Food Chemistry, vol. 265, 2018, pp. 101-110.
Sáez V, Pastene E, Vergara C, et al. Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells. Food Chem. 2018;265:101-110.
Sáez, V., Pastene, E., Vergara, C., Mardones, C., Hermosín-Gutiérrez, I., Gómez-Alonso, S., Gómez, M. V., Theoduloz, C., Riquelme, S., & von Baer, D. (2018). Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells. Food Chemistry, 265, 101-110. https://doi.org/10.1016/j.foodchem.2018.05.050
Sáez V, et al. Oligostilbenoids in Vitis Vinifera L. Pinot Noir Grape Cane Extract: Isolation, Characterization, in Vitro Antioxidant Capacity and Anti-proliferative Effect On Cancer Cells. Food Chem. 2018 Nov 1;265:101-110. PubMed PMID: 29884360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells. AU - Sáez,Vania, AU - Pastene,Edgar, AU - Vergara,Carola, AU - Mardones,Claudia, AU - Hermosín-Gutiérrez,Isidro, AU - Gómez-Alonso,Sergio, AU - Gómez,M Victoria, AU - Theoduloz,Cristina, AU - Riquelme,Sebastián, AU - von Baer,Dietrich, Y1 - 2018/05/10/ PY - 2017/12/01/received PY - 2018/04/21/revised PY - 2018/05/08/accepted PY - 2018/6/10/entrez PY - 2018/6/10/pubmed PY - 2018/10/3/medline KW - (E)-Piceatannol (PubChem CID 667639) KW - (E)-Resveratrol KW - (E)-Resveratrol (PubChem CID 445154) KW - (E)-δ-Viniferin (PubChem CID 11487842) KW - (E)-ε-Viniferin (PubChem CID 5315233) KW - (E)-ω-Viniferin (PubChem CID 72551484) KW - Ampelopsin A (PubChem CID 182999) KW - Antioxidant capacity KW - Antiproliferative effect KW - Grape cane KW - Isorhapontigenin (PubChem CID 5318650) KW - Oligostilbenoids KW - Pallidol (PubChem CID 484757) KW - Scirpusin A (PubChem CID 5458896) KW - Vitisin B (PubChem CID 71308302) SP - 101 EP - 110 JF - Food chemistry JO - Food Chem VL - 265 N2 - The following oligostilbenoids were isolated from extracts of Vitis vinifera L. Pinot Noir grape canes produced at a pilot-plant scale: (E)-ε-viniferin, (E)-resveratrol, (E)-piceatannol, ampelopsin A, vitisin B, pallidol, (E)-δ-viniferin, (E)-ω-viniferin, (E)-trans-cis-miyabenol C, isorhapontigenin, scirpusin A, and a new isomer named isoscirpusin A. The antioxidant capacity of the isolated stilbenoids was studied by three different assays, and their 50% inhibition concentration (IC50) against cancer cells was determined by MTT reduction assay. Besides (E)-resveratrol, stilbenoids have outstanding antioxidant capacity in the ORAC-FL assay. The strongest antiproliferative effect was observed for (E)-piceatannol and ampelopsin A against the bladder cancer cell line J82. (E)-Piceatannol has inhibitory effect on human lung cancer SK-MES-1 cells. Moreover, the whole extract has antiproliferative effect on all tested cell lines. In conclusion, beside (E)-resveratrol, grape cane extract contains oligostilbenoids with potential health benefits. This underexploited viticultural residue has the potential to produce valuable phytochemicals or ingredients in functional foods. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/29884360/Oligostilbenoids_in_Vitis_vinifera_L__Pinot_Noir_grape_cane_extract:_Isolation_characterization_in_vitro_antioxidant_capacity_and_anti_proliferative_effect_on_cancer_cells_ DB - PRIME DP - Unbound Medicine ER -