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CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool.
J Mol Biol. 2019 01 04; 431(1):88-101.JM

Abstract

With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are exceeding beyond research and biomedical therapies, new and existing ethical concerns abound throughout the global community about the appropriate scope of the systems' use. Here we review fundamental ethical issues including the following: 1) the extent to which CRISPR use should be permitted; 2) access to CRISPR applications; 3) whether a regulatory framework(s) for clinical research involving human subjects might accommodate all types of human genome editing, including editing of the germline; and 4) whether international regulations governing inappropriate CRISPR utilization should be crafted and publicized. We conclude that moral decision making should evolve as the science of genomic engineering advances and hold that it would be reasonable for national and supranational legislatures to consider evidence-based regulation of certain CRISPR applications for the betterment of human health and progress.

Authors+Show Affiliations

Department of Emergency Medicine, Yale School of Medicine, 464 Congress Avenue, New Haven, CT 06519-1362, USA.Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA. Electronic address: adli@virginia.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29885329

Citation

Brokowski, Carolyn, and Mazhar Adli. "CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool." Journal of Molecular Biology, vol. 431, no. 1, 2019, pp. 88-101.
Brokowski C, Adli M. CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool. J Mol Biol. 2019;431(1):88-101.
Brokowski, C., & Adli, M. (2019). CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool. Journal of Molecular Biology, 431(1), 88-101. https://doi.org/10.1016/j.jmb.2018.05.044
Brokowski C, Adli M. CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool. J Mol Biol. 2019 01 4;431(1):88-101. PubMed PMID: 29885329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool. AU - Brokowski,Carolyn, AU - Adli,Mazhar, Y1 - 2018/06/07/ PY - 2018/03/18/received PY - 2018/05/30/revised PY - 2018/05/30/accepted PY - 2018/6/10/pubmed PY - 2020/3/5/medline PY - 2018/6/10/entrez KW - CRISPR–Cas9 KW - bioengineering KW - genetic engineering KW - genome editing KW - research ethics SP - 88 EP - 101 JF - Journal of molecular biology JO - J. Mol. Biol. VL - 431 IS - 1 N2 - With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are exceeding beyond research and biomedical therapies, new and existing ethical concerns abound throughout the global community about the appropriate scope of the systems' use. Here we review fundamental ethical issues including the following: 1) the extent to which CRISPR use should be permitted; 2) access to CRISPR applications; 3) whether a regulatory framework(s) for clinical research involving human subjects might accommodate all types of human genome editing, including editing of the germline; and 4) whether international regulations governing inappropriate CRISPR utilization should be crafted and publicized. We conclude that moral decision making should evolve as the science of genomic engineering advances and hold that it would be reasonable for national and supranational legislatures to consider evidence-based regulation of certain CRISPR applications for the betterment of human health and progress. SN - 1089-8638 UR - https://www.unboundmedicine.com/medline/citation/29885329/CRISPR_Ethics:_Moral_Considerations_for_Applications_of_a_Powerful_Tool_ DB - PRIME DP - Unbound Medicine ER -