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Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity.
Eur Neuropsychopharmacol 2018; 28(7):841-849EN

Abstract

Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are two substances from cannabis sativa that have beenimplicated in the treatment of mental and neurological disorders. We concentrated on a previously validated neuroimaging phenotype, fronto-striatal connectivity across different striatal seeds, because of this loop's relevance to executive functioning, decision making, salience generation and motivation and its link to various neuropsychiatric conditions. Therefore, we studied the effect of THC and CBD on fronto-striatal circuitry by a seed-voxel connectivity approach using seeds from the caudate and the putamen. We conducted a cross-over pharmaco-fMRI study in 16 healthy male volunteers with placebo, 10 mg oral THC and 600 mg oral CBD. Resting state was measured in a 3 T scanner. CBD lead to an increase of fronto-striatal connectivity in comparison to placebo. In contrast to our expectation that THC and CBD show opposing effects, THC versus placebo did not show any significant effects, probably due to insufficient concentration of THC during scanning. The effect of CBD on enhancing fronto-striatal connectivity is of interest because it might be a neural correlate of its anti-psychotic effect in patients.

Authors+Show Affiliations

Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany; Department of Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Frankfurt am Main, Germany.Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany; Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29887287

Citation

Grimm, Oliver, et al. "Probing the Endocannabinoid System in Healthy Volunteers: Cannabidiol Alters Fronto-striatal Resting-state Connectivity." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 28, no. 7, 2018, pp. 841-849.
Grimm O, Löffler M, Kamping S, et al. Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity. Eur Neuropsychopharmacol. 2018;28(7):841-849.
Grimm, O., Löffler, M., Kamping, S., Hartmann, A., Rohleder, C., Leweke, M., & Flor, H. (2018). Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 28(7), pp. 841-849. doi:10.1016/j.euroneuro.2018.04.004.
Grimm O, et al. Probing the Endocannabinoid System in Healthy Volunteers: Cannabidiol Alters Fronto-striatal Resting-state Connectivity. Eur Neuropsychopharmacol. 2018;28(7):841-849. PubMed PMID: 29887287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity. AU - Grimm,Oliver, AU - Löffler,Martin, AU - Kamping,Sandra, AU - Hartmann,Aljoscha, AU - Rohleder,Cathrin, AU - Leweke,Markus, AU - Flor,Herta, Y1 - 2018/06/07/ PY - 2017/07/18/received PY - 2018/04/25/revised PY - 2018/04/30/accepted PY - 2018/6/12/pubmed PY - 2019/4/25/medline PY - 2018/6/12/entrez KW - Cannabidiol KW - Frontal cortex KW - Functional connectivity KW - Resting state fMRI KW - Striatum KW - Tetrahydrocannabinol SP - 841 EP - 849 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 28 IS - 7 N2 - Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are two substances from cannabis sativa that have beenimplicated in the treatment of mental and neurological disorders. We concentrated on a previously validated neuroimaging phenotype, fronto-striatal connectivity across different striatal seeds, because of this loop's relevance to executive functioning, decision making, salience generation and motivation and its link to various neuropsychiatric conditions. Therefore, we studied the effect of THC and CBD on fronto-striatal circuitry by a seed-voxel connectivity approach using seeds from the caudate and the putamen. We conducted a cross-over pharmaco-fMRI study in 16 healthy male volunteers with placebo, 10 mg oral THC and 600 mg oral CBD. Resting state was measured in a 3 T scanner. CBD lead to an increase of fronto-striatal connectivity in comparison to placebo. In contrast to our expectation that THC and CBD show opposing effects, THC versus placebo did not show any significant effects, probably due to insufficient concentration of THC during scanning. The effect of CBD on enhancing fronto-striatal connectivity is of interest because it might be a neural correlate of its anti-psychotic effect in patients. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/29887287/Probing_the_endocannabinoid_system_in_healthy_volunteers:_Cannabidiol_alters_fronto_striatal_resting_state_connectivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(18)30113-5 DB - PRIME DP - Unbound Medicine ER -