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Incidence of cancer (other than gastric cancer) in pernicious anaemia: A systematic review with meta-analysis.
Dig Liver Dis 2018; 50(8):780-786DL

Abstract

BACKGROUND

Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers.

AIM

To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC.

METHODS

Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017). A meta-analysis of annual cancer incidence rates was performed. The outcome was the cumulative incidence of GI-other-than-GCs and non-GICs (ratio between the numbers of new cancer cases identified during the follow-up period and the number of PA patients) and the incidence rate expressed as the rate of events-per-time-unit (person-years).

RESULTS

Of 82,257 PA patients, the pooled incidence rates/100 person-years for non-GCs and non-GICs of 0.27 (95% CI:0.16-0.42) and 0.23 (95% CI:0.22-0.25) were calculated by meta-analysis. Compared to the GLOBOCAN data for the general population from the countries of the included studies, the meta-analysis showed an overall relative risk (RR) of cancer in PA of 0.68 (95% CI:0.48-0.95). PA patients had a lower RR of colorectal, breast, liver, oesophageal, lung, thyroid, ovary, non-melanoma skin and kidney cancers but had a higher RR of biliary tract cancer (1.81:1.21-2.70), multiple myeloma (2.83:1.76-4.55), Hodgkin's lymphoma (3.0:1.35-6.68), non-Hodgkin's lymphoma (2.08: 1.58-2.75), and leukaemia (1.56:1.16-2.12).

CONCLUSION

An overall lower RR of cancers-other-than-gastric-cancer in PA patients but an increased RR of biliary tract cancers and haematological malignancies was observed.

Authors+Show Affiliations

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sapienza University of Rome, Italy. Electronic address: edith.lahner@uniroma1.it.Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sapienza University of Rome, Italy.Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sapienza University of Rome, Italy.Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sapienza University of Rome, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

29887343

Citation

Lahner, Edith, et al. "Incidence of Cancer (other Than Gastric Cancer) in Pernicious Anaemia: a Systematic Review With Meta-analysis." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 50, no. 8, 2018, pp. 780-786.
Lahner E, Capasso M, Carabotti M, et al. Incidence of cancer (other than gastric cancer) in pernicious anaemia: A systematic review with meta-analysis. Dig Liver Dis. 2018;50(8):780-786.
Lahner, E., Capasso, M., Carabotti, M., & Annibale, B. (2018). Incidence of cancer (other than gastric cancer) in pernicious anaemia: A systematic review with meta-analysis. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 50(8), pp. 780-786. doi:10.1016/j.dld.2018.05.012.
Lahner E, et al. Incidence of Cancer (other Than Gastric Cancer) in Pernicious Anaemia: a Systematic Review With Meta-analysis. Dig Liver Dis. 2018;50(8):780-786. PubMed PMID: 29887343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of cancer (other than gastric cancer) in pernicious anaemia: A systematic review with meta-analysis. AU - Lahner,Edith, AU - Capasso,Marina, AU - Carabotti,Marilia, AU - Annibale,Bruno, Y1 - 2018/05/24/ PY - 2018/01/11/received PY - 2018/05/16/revised PY - 2018/05/17/accepted PY - 2018/6/12/pubmed PY - 2018/11/18/medline PY - 2018/6/12/entrez KW - Autoimmune gastritis KW - Biliary tract cancer KW - Cancer risk KW - Leukaemia KW - Lymphoma KW - Meta-analysis KW - Pernicious anaemia KW - Systematic review SP - 780 EP - 786 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 50 IS - 8 N2 - BACKGROUND: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC. METHODS: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017). A meta-analysis of annual cancer incidence rates was performed. The outcome was the cumulative incidence of GI-other-than-GCs and non-GICs (ratio between the numbers of new cancer cases identified during the follow-up period and the number of PA patients) and the incidence rate expressed as the rate of events-per-time-unit (person-years). RESULTS: Of 82,257 PA patients, the pooled incidence rates/100 person-years for non-GCs and non-GICs of 0.27 (95% CI:0.16-0.42) and 0.23 (95% CI:0.22-0.25) were calculated by meta-analysis. Compared to the GLOBOCAN data for the general population from the countries of the included studies, the meta-analysis showed an overall relative risk (RR) of cancer in PA of 0.68 (95% CI:0.48-0.95). PA patients had a lower RR of colorectal, breast, liver, oesophageal, lung, thyroid, ovary, non-melanoma skin and kidney cancers but had a higher RR of biliary tract cancer (1.81:1.21-2.70), multiple myeloma (2.83:1.76-4.55), Hodgkin's lymphoma (3.0:1.35-6.68), non-Hodgkin's lymphoma (2.08: 1.58-2.75), and leukaemia (1.56:1.16-2.12). CONCLUSION: An overall lower RR of cancers-other-than-gastric-cancer in PA patients but an increased RR of biliary tract cancers and haematological malignancies was observed. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/29887343/Incidence_of_cancer__other_than_gastric_cancer__in_pernicious_anaemia:_A_systematic_review_with_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(18)30756-4 DB - PRIME DP - Unbound Medicine ER -