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Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers.
J Alzheimers Dis. 2018; 64(1):281-290.JA

Abstract

BACKGROUND

There is accumulating evidence suggesting that diet may play a role in preventing or delaying cognitive decline and dementia, but the underlying biological mechanisms are not well understood.

OBJECTIVES

To examine the cross-sectional associations of the Mediterranean diet (MeDi) and its components with 11C-PiB-PET scan measures of amyloid-β (Aβ) deposition.

METHODS

The study consisted of 278 Mayo Clinic Study of Aging participants 70+ years old, who were cognitively unimpaired (CU) at the time of completion of the Food Frequency Questionnaire (FFQ) and when they underwent PET imaging. Adherence to the MeDi was assessed by computing the MeDi score for each participant. All scans were performed after the FFQ completion; median [IQR] time between FFQ and Aβ PET was 3.5 (1.4) years. Z-scores were created for component, macro- and micronutrients measured. Linear and logistic regression models were adjusted for age, sex, education, apolipoprotein E (APOE) ɛ4 allele carrier status, time interval between the FFQ completion and PET scan, and total energy intake.

RESULTS

Participants' median age at FFQ was 77.7 years (55.8% men; 26.6% with an APOE ɛ4 allele). Higher MeDi score (linear regression slope (beta):-0.035, p = 0.012; per standard deviation increase), vegetable intake (beta:-0.043, p = 0.002), intake of vitamin A (beta:-0.041, p = 0.003) or β-carotene (beta: -0.039, p = 0.005) from food sources and moderate alcohol consumption (beta: -0.074, p = 0.03) were associated with lower 11C-PiB standardized uptake value ratio.

CONCLUSION

Findings are consistent with previous studies suggesting that higher adherence to a MeDi pattern and higher vegetable consumption are associated with better neuroimaging biomarker profile. Prospective studies are needed to validate current findings.

Links

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Authors+Show Affiliations

Vassilaki M
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Aakre JA
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Syrjanen JA
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Mielke MM
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Geda YE
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Department of Psychiatry and Psychology and Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Kremers WK
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Machulda MM
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Alhurani RE
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Staubo SC
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Charles University in Prague, Faculty in Hradec Kralove, Hradec Kralove, Czech Republic.
Knopman DS
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Petersen RC
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Lowe VJ
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Jack CR
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Roberts RO
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Department of Neurology, Mayo Clinic, Rochester, MN, USA.

MeSH

AgedAged, 80 and overAmyloidAniline CompoundsBrainCognitive DysfunctionCohort StudiesCross-Sectional StudiesDementiaDiet, MediterraneanFemaleHumansMaleNeuropsychological TestsPositron-Emission TomographyProspective StudiesPsychiatric Status Rating ScalesSurveys and QuestionnairesThiazoles

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29889074

Citation

Vassilaki, Maria, et al. "Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers." Journal of Alzheimer's Disease : JAD, vol. 64, no. 1, 2018, pp. 281-290.
Vassilaki M, Aakre JA, Syrjanen JA, et al. Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. J Alzheimers Dis. 2018;64(1):281-290.
Vassilaki, M., Aakre, J. A., Syrjanen, J. A., Mielke, M. M., Geda, Y. E., Kremers, W. K., Machulda, M. M., Alhurani, R. E., Staubo, S. C., Knopman, D. S., Petersen, R. C., Lowe, V. J., Jack, C. R., & Roberts, R. O. (2018). Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. Journal of Alzheimer's Disease : JAD, 64(1), 281-290. https://doi.org/10.3233/JAD-171121
Vassilaki M, et al. Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. J Alzheimers Dis. 2018;64(1):281-290. PubMed PMID: 29889074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. AU - Vassilaki,Maria, AU - Aakre,Jeremiah A, AU - Syrjanen,Jeremy A, AU - Mielke,Michelle M, AU - Geda,Yonas E, AU - Kremers,Walter K, AU - Machulda,Mary M, AU - Alhurani,Rabe E, AU - Staubo,Sara C, AU - Knopman,David S, AU - Petersen,Ronald C, AU - Lowe,Val J, AU - Jack,Clifford R, AU - Roberts,Rosebud O, PY - 2018/6/12/entrez PY - 2018/6/12/pubmed PY - 2019/6/27/medline KW - Amyloid KW - Mediterranean diet KW - cross-sectional study KW - vegetables SP - 281 EP - 290 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 64 IS - 1 N2 - BACKGROUND: There is accumulating evidence suggesting that diet may play a role in preventing or delaying cognitive decline and dementia, but the underlying biological mechanisms are not well understood. OBJECTIVES: To examine the cross-sectional associations of the Mediterranean diet (MeDi) and its components with 11C-PiB-PET scan measures of amyloid-β (Aβ) deposition. METHODS: The study consisted of 278 Mayo Clinic Study of Aging participants 70+ years old, who were cognitively unimpaired (CU) at the time of completion of the Food Frequency Questionnaire (FFQ) and when they underwent PET imaging. Adherence to the MeDi was assessed by computing the MeDi score for each participant. All scans were performed after the FFQ completion; median [IQR] time between FFQ and Aβ PET was 3.5 (1.4) years. Z-scores were created for component, macro- and micronutrients measured. Linear and logistic regression models were adjusted for age, sex, education, apolipoprotein E (APOE) ɛ4 allele carrier status, time interval between the FFQ completion and PET scan, and total energy intake. RESULTS: Participants' median age at FFQ was 77.7 years (55.8% men; 26.6% with an APOE ɛ4 allele). Higher MeDi score (linear regression slope (beta):-0.035, p = 0.012; per standard deviation increase), vegetable intake (beta:-0.043, p = 0.002), intake of vitamin A (beta:-0.041, p = 0.003) or β-carotene (beta: -0.039, p = 0.005) from food sources and moderate alcohol consumption (beta: -0.074, p = 0.03) were associated with lower 11C-PiB standardized uptake value ratio. CONCLUSION: Findings are consistent with previous studies suggesting that higher adherence to a MeDi pattern and higher vegetable consumption are associated with better neuroimaging biomarker profile. Prospective studies are needed to validate current findings. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/29889074/Mediterranean_Diet_Its_Components_and_Amyloid_Imaging_Biomarkers_ DB - PRIME DP - Unbound Medicine ER -