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A novel dimeric flavonol glycoside from Cynanchum acutum subsp. sibiricum.
Nat Prod Res. 2019 Jul; 33(14):2032-2037.NP

Abstract

A novel dimeric flavonol glycoside, Cynanflavoside A (1), together with six analogues, kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (2), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (3), kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (4), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (5), kaempferol-3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (6), and quercetin-3-O-galactoside (7) were isolated from the n-butyl alcohol extract of Cynanchum acutum subsp. sibiricum. Their structures were determined spectroscopically and compared with previously reported spectral data. All compounds were evaluated for their anti-complementary activity in vitro, and only compound 5 exhibited anti-complement effects with CH50 value of 0.33 mM.

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Authors+Show Affiliations

Yuan SW
a Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, School of Pharmacy, Ministry of Education , Shihezi University , Shihezi , P.R. China.
Dai W
a Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, School of Pharmacy, Ministry of Education , Shihezi University , Shihezi , P.R. China.
Pan XH
a Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, School of Pharmacy, Ministry of Education , Shihezi University , Shihezi , P.R. China.
Lu Y
b School of Pharmacy, Department of Pharmacognosy , Fudan University , Shanghai , P.R. China.
Chen DF
b School of Pharmacy, Department of Pharmacognosy , Fudan University , Shanghai , P.R. China.
Wang Q
a Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, School of Pharmacy, Ministry of Education , Shihezi University , Shihezi , P.R. China.

MeSH

Complement Inactivator ProteinsCynanchumFlavonolsGlycosidesKaempferolsQuercetin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29890861

Citation

Yuan, Si-Wen, et al. "A Novel Dimeric Flavonol Glycoside From Cynanchum Acutum Subsp. Sibiricum." Natural Product Research, vol. 33, no. 14, 2019, pp. 2032-2037.
Yuan SW, Dai W, Pan XH, et al. A novel dimeric flavonol glycoside from Cynanchum acutum subsp. sibiricum. Nat Prod Res. 2019;33(14):2032-2037.
Yuan, S. W., Dai, W., Pan, X. H., Lu, Y., Chen, D. F., & Wang, Q. (2019). A novel dimeric flavonol glycoside from Cynanchum acutum subsp. sibiricum. Natural Product Research, 33(14), 2032-2037. https://doi.org/10.1080/14786419.2018.1483931
Yuan SW, et al. A Novel Dimeric Flavonol Glycoside From Cynanchum Acutum Subsp. Sibiricum. Nat Prod Res. 2019;33(14):2032-2037. PubMed PMID: 29890861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel dimeric flavonol glycoside from Cynanchum acutum subsp. sibiricum. AU - Yuan,Si-Wen, AU - Dai,Wei, AU - Pan,Xin-Hui, AU - Lu,Yan, AU - Chen,Dao-Feng, AU - Wang,Qi, Y1 - 2018/06/11/ PY - 2018/6/13/pubmed PY - 2019/8/23/medline PY - 2018/6/13/entrez KW - subsp KW - Asclepiadaceae KW - anti-complementary activity KW - dimeric flavonol glycoside SP - 2032 EP - 2037 JF - Natural product research JO - Nat Prod Res VL - 33 IS - 14 N2 - A novel dimeric flavonol glycoside, Cynanflavoside A (1), together with six analogues, kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (2), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (3), kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (4), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (5), kaempferol-3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (6), and quercetin-3-O-galactoside (7) were isolated from the n-butyl alcohol extract of Cynanchum acutum subsp. sibiricum. Their structures were determined spectroscopically and compared with previously reported spectral data. All compounds were evaluated for their anti-complementary activity in vitro, and only compound 5 exhibited anti-complement effects with CH50 value of 0.33 mM. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/29890861/A_novel_dimeric_flavonol_glycoside_from_Cynanchum_acutum_subsp__sibiricum_ DB - PRIME DP - Unbound Medicine ER -